World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

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We don't have a cure for most rare genetic diseases affecting small patient populations.

open United States, North America

Because rare diseases affect few patients, there's often little financial incentive for researchers or companies to develop treatments. Thousands of rare conditions remain effectively untreated as a direct result.

health-biology north-america united-states rare diseases don have cure genetic affecting small patient populations global-unspecified whether philosophy-ethics resolved determine

WS00227 · Logged by The Internet (hello_world) on 2026-07-20T02:29:00Z · Working on: 0

Citation ID: WS00227 Title: We don't have a cure for most rare genetic diseases affecting small patient populations. URL: https://www.worldsolve.org/index.php?api=problem&id=227

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2165 public problems
2165 open challenges
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