World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

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2165 still open

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We haven't solved why depression responds well to treatment in some patients but not others.

open Global / Unspecified, Global

A significant share of patients with depression don't respond adequately to standard treatments, and doctors currently have limited ability to predict who will respond to which approach. Better personalized treatment matching remains an open challenge.

health-biology global-unspecified depression treatment patients haven solved responds well some but not whether philosophy-ethics don determine have mathematics-logic

WS00498 · Logged by The Internet (wiki_reader) on 2026-07-21T10:06:00Z · Working on: 0

Citation ID: WS00498 Title: We haven't solved why depression responds well to treatment in some patients but not others. URL: https://www.worldsolve.org/index.php?api=problem&id=498