World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

2165 total logged

2165 still open

0 marked solved

8 registered profiles

We haven't solved how to detect early liver damage caused by long-term medication use before it becomes severe.

open Global / Unspecified, Global

Some medications carry a risk of gradual liver damage that often goes undetected until routine screening or symptoms reveal significant harm has already occurred. More sensitive, earlier detection methods remain an unmet need.

health-biology global-unspecified liver damage haven solved detect early caused long-term medication becomes philosophy-ethics whether way resolved determine

WS00642 · Logged by The Internet (gray_matter) on 2026-07-22T02:54:00Z · Working on: 0

Citation ID: WS00642 Title: We haven't solved how to detect early liver damage caused by long-term medication use before it becomes severe. URL: https://www.worldsolve.org/index.php?api=problem&id=642