We don't fully understand why some people age much slower than others.
open
Global / Unspecified, Global
Some people reach old age with sharp minds and healthy bodies, while others decline much earlier, and genetics only explains part of it. Understanding this gap could extend healthy years of life for far more people.
philosophy-ethics
global-unspecified
people
some
age
others
don
fully
understand
slower
healthy
reach
whether
resolved
know
haven
determine
mathematics-logic
Citation ID: WS00065
Title: We don't fully understand why some people age much slower than others.
URL: https://www.worldsolve.org/index.php?api=problem&id=65
We haven't solved chronic pain well enough to treat it without risking addiction.
open
Global / Unspecified, Global
Millions of people with chronic pain are stuck choosing between inadequate relief or medications that carry serious addiction risk. A safer, equally effective alternative remains one of medicine's most requested breakthroughs.
health-biology
global-unspecified
chronic
pain
addiction
haven
solved
well
enough
treat
risking
millions
philosophy-ethics
whether
determine
resolved
mathematics-logic
Citation ID: WS00064
Title: We haven't solved chronic pain well enough to treat it without risking addiction.
URL: https://www.worldsolve.org/index.php?api=problem&id=64
We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
open
Global / Unspecified, Global
Bacteria are evolving resistance faster than pharmaceutical companies are creating new antibiotics to fight them. Left unresolved, common infections could become deadly again within a few decades.
health-biology
global-unspecified
bacteria
faster
new
antibiotics
stop
antibiotic-resistant
spreading
develop
evolving
resistance
philosophy-ethics
whether
resolved
haven
climate-environment
Citation ID: WS00063
Title: We can't stop antibiotic-resistant bacteria from spreading faster than we develop new antibiotics.
URL: https://www.worldsolve.org/index.php?api=problem&id=63
We don't have affordable cancer screening that catches every type early enough to treat well.
open
Global / Unspecified, Global
Some cancers are caught early and treated successfully, while others are found too late simply because no cheap, accurate screening exists for them. Broader early detection could save far more lives than treatment breakthroughs alone.
health-biology
global-unspecified
early
screening
don
have
affordable
cancer
catches
every
type
enough
whether
philosophy-ethics
determine
haven
way
resolved
Citation ID: WS00062
Title: We don't have affordable cancer screening that catches every type early enough to treat well.
URL: https://www.worldsolve.org/index.php?api=problem&id=62
We haven't found a cure for the common cold despite decades of trying.
open
Global / Unspecified, Global
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
health-biology
global-unspecified
cure
cold
haven
found
common
despite
decades
trying
hundreds
different
whether
philosophy-ethics
mathematics-logic
way
determine
Citation ID: WS00061
Title: We haven't found a cure for the common cold despite decades of trying.
URL: https://www.worldsolve.org/index.php?api=problem&id=61
We can't grow replacement organs that a patient's body won't reject.
open
Global / Unspecified, Global
Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.
local-regional
global-unspecified
organs
patient
body
grow
replacement
won
reject
organ
transplants
require
haven
north-america
united-states
solved
donor
health-biology
Citation ID: WS00060
Title: We can't grow replacement organs that a patient's body won't reject.
URL: https://www.worldsolve.org/index.php?api=problem&id=60
We don't have a universal vaccine that protects against all strains of the flu.
open
United States, North America
The flu virus mutates constantly, forcing a new vaccine guess every year that sometimes misses the mark. A universal flu vaccine could end this annual guessing game and prevent thousands of deaths.
health-biology
north-america
united-states
vaccine
flu
universal
don
have
protects
against
all
strains
virus
global-unspecified
whether
philosophy-ethics
determine
mathematics-logic
Citation ID: WS00059
Title: We don't have a universal vaccine that protects against all strains of the flu.
URL: https://www.worldsolve.org/index.php?api=problem&id=59
We can't cure most autoimmune diseases, only manage their symptoms.
open
Global / Unspecified, Global
Conditions like lupus, rheumatoid arthritis, and multiple sclerosis occur when the body attacks itself, and current treatments mostly suppress symptoms rather than fix the root cause. Millions live with lifelong management instead of a real cure.
health-biology
global-unspecified
cure
symptoms
autoimmune
diseases
only
manage
conditions
like
lupus
rheumatoid
philosophy-ethics
whether
don
mathematics-logic
haven
have
Citation ID: WS00058
Title: We can't cure most autoimmune diseases, only manage their symptoms.
URL: https://www.worldsolve.org/index.php?api=problem&id=58
We don't have enough clean water infrastructure to serve growing cities in dry regions.
open
Global / Unspecified, Global
Many fast-growing cities in arid regions are outpacing the water systems built to serve them, leading to shortages and rationing. Solving this needs both new infrastructure and smarter long-term water planning.
sdg-sustainable-development-goals
global-unspecified
water
infrastructure
serve
cities
regions
don
have
enough
clean
growing
urban
climate-environment
african
whether
Citation ID: WS00057
Title: We don't have enough clean water infrastructure to serve growing cities in dry regions.
URL: https://www.worldsolve.org/index.php?api=problem&id=57
We haven't solved how to make air travel low-carbon without making it unaffordable.
open
Global / Unspecified, Global
Sustainable aviation fuel and electric planes exist in early forms but remain far more expensive than traditional jet fuel. Making clean flying both effective and affordable is still an open engineering and economic problem.
economics-resources
global-unspecified
making
haven
solved
make
air
travel
low-carbon
unaffordable
fuel
sustainable
whether
philosophy-ethics
affordable
health-biology
mathematics-logic
climate-environment
Citation ID: WS00056
Title: We haven't solved how to make air travel low-carbon without making it unaffordable.
URL: https://www.worldsolve.org/index.php?api=problem&id=56
We can't stop rivers and groundwater from being drained faster than they refill.
open
Global / Unspecified, Global
Many major rivers and aquifers are being pumped or diverted faster than rainfall can replenish them, threatening long-term water security. Without better management, some regions may simply run out of accessible fresh water.
climate-environment
global-unspecified
rivers
being
faster
stop
groundwater
drained
refill
water
major
aquifers
long
urban
threatens
utilities
don
pollution
Citation ID: WS00055
Title: We can't stop rivers and groundwater from being drained faster than they refill.
URL: https://www.worldsolve.org/index.php?api=problem&id=55
We don't have a fair way to relocate people displaced by rising sea levels.
open
Global / Unspecified, Global
Entire island nations and coastal communities face losing their homes permanently, with no agreed international process for where they go or who helps pay for it. This is already happening, not just a future risk.
philosophy-ethics
global-unspecified
don
have
fair
way
relocate
people
displaced
rising
sea
levels
whether
determine
agreed
resolved
haven
Citation ID: WS00054
Title: We don't have a fair way to relocate people displaced by rising sea levels.
URL: https://www.worldsolve.org/index.php?api=problem&id=54
We haven't built cities that can absorb floodwater instead of being destroyed by it.
open
Global / Unspecified, Global
Paved surfaces send rainwater rushing into drains that quickly overflow during storms, instead of letting it soak into the ground. Cities designed to absorb water naturally would suffer far less flood damage.
climate-environment
global-unspecified
cities
absorb
instead
haven
built
floodwater
being
destroyed
paved
surfaces
urban
african
water
infrastructure
systems
growing
Citation ID: WS00053
Title: We haven't built cities that can absorb floodwater instead of being destroyed by it.
URL: https://www.worldsolve.org/index.php?api=problem&id=53
We can't track and reduce methane leaks from oil and gas infrastructure worldwide.
open
Global / Unspecified, Global
Methane is a far more potent greenhouse gas than carbon dioxide in the short term, and much of it leaks unnoticed from pipelines and wells. Better detection and faster repairs could meaningfully slow near-term warming.
climate-environment
global-unspecified
methane
leaks
gas
track
reduce
oil
infrastructure
worldwide
far
potent
emissions
farming
rice
way
don
have
Citation ID: WS00052
Title: We can't track and reduce methane leaks from oil and gas infrastructure worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=52
We don't have crops resilient enough to survive increasingly unpredictable weather patterns.
open
Global / Unspecified, Global
Droughts, floods, and shifting seasons are making traditional farming less reliable in many regions. Crops that can handle this unpredictability are essential to keeping global food supply stable.
climate-environment
global-unspecified
crops
don
have
resilient
enough
survive
increasingly
unpredictable
weather
patterns
whether
philosophy-ethics
determine
agreed
way
reliable
Citation ID: WS00051
Title: We don't have crops resilient enough to survive increasingly unpredictable weather patterns.
URL: https://www.worldsolve.org/index.php?api=problem&id=51
We haven't found an affordable substitute for cement that doesn't release as much carbon.
open
Global / Unspecified, Global
Cement production alone accounts for a huge share of global carbon emissions, yet it remains central to nearly all construction. A low-carbon alternative that's just as strong and cheap would be one of climate policy's biggest wins.
climate-environment
global-unspecified
carbon-emissions
cement
carbon
haven
found
affordable
substitute
doesn
release
production
alone
whether
philosophy-ethics
mathematics-logic
way
resolved
Citation ID: WS00050
Title: We haven't found an affordable substitute for cement that doesn't release as much carbon.
URL: https://www.worldsolve.org/index.php?api=problem&id=50
We can't rebuild coral reefs fast enough to keep pace with ocean warming.
open
Global / Unspecified, Global
Coral bleaching events are becoming more frequent as ocean temperatures rise, and restoration efforts are still small and slow. Without faster recovery methods, many reef ecosystems may not survive this century.
climate-environment
global-unspecified
coral
ocean
rebuild
reefs
fast
enough
keep
pace
warming
bleaching
yet
pollution
whether
way
philosophy-ethics
fully
Citation ID: WS00049
Title: We can't rebuild coral reefs fast enough to keep pace with ocean warming.
URL: https://www.worldsolve.org/index.php?api=problem&id=49
We don't have a way to stop wildfires from growing more frequent and destructive each year.
open
Global / Unspecified, Global
Hotter, drier conditions combined with decades of fire suppression have left forests primed to burn catastrophically. Managing this risk needs new approaches to land management, not just faster firefighting.
climate-environment
global-unspecified
have
don
way
stop
wildfires
growing
frequent
destructive
each
year
philosophy-ethics
determine
whether
agreed
resolved
prevent
Citation ID: WS00048
Title: We don't have a way to stop wildfires from growing more frequent and destructive each year.
URL: https://www.worldsolve.org/index.php?api=problem&id=48
We haven't figured out how to farm seafood without collapsing wild fish populations.
open
Global / Unspecified, Global
Fish farming was supposed to relieve pressure on wild fisheries, but many farms still rely on wild-caught fish for feed. A truly sustainable seafood system would need to break that dependency entirely.
mathematics-logic
global-unspecified
fish
seafood
wild
haven
figured
out
farm
collapsing
populations
farming
philosophy-ethics
whether
yet
prevent
climate-environment
Citation ID: WS00047
Title: We haven't figured out how to farm seafood without collapsing wild fish populations.
URL: https://www.worldsolve.org/index.php?api=problem&id=47
We can't cool cities enough to protect people during increasingly severe heat waves.
open
Global / Unspecified, Global
Concrete and asphalt trap heat, turning cities into dangerous hot zones during extreme weather, especially for people without air conditioning. Redesigning cities to stay cooler is now a matter of public safety, not comfort.
social-civic-problems
global-unspecified
cities
people
during
heat
cool
enough
protect
increasingly
severe
waves
urban
african
haven
water
climate-environment
asia
Citation ID: WS00046
Title: We can't cool cities enough to protect people during increasingly severe heat waves.
URL: https://www.worldsolve.org/index.php?api=problem&id=46