Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
This rare but severe condition can develop rapidly after childbirth, and delays in recognition and treatment can have dangerous consequences for both mother and baby. Faster, more reliable detection and treatment protocols remain an urgent unmet need.
health-biology
global-unspecified
haven
solved
treat
postpartum
psychosis
quickly
enough
prevent
serious
harm
whether
philosophy-ethics
way
determine
resolved
don
open
Global / Unspecified, Global
Diabetic retinopathy remains a leading cause of blindness among working-age adults, and while treatment can slow progression, prevention before damage begins remains incomplete. Earlier, more effective prevention could protect vision for millions of diabetics.
health-biology
global-unspecified
diabetic
vision
retinopathy
yet
fully
prevent
loss
caused
all
patients
philosophy-ethics
whether
way
mathematics-logic
resolved
haven
open
Global / Unspecified, Global
Malnutrition rates spike dramatically in areas affected by war, but delivering treatment consistently in unstable, hard-to-reach regions remains a persistent logistical and medical challenge. Solving this requires both medical and access innovation.
health-biology
global-unspecified
malnutrition
access
don
have
scalable
solution
treating
conflict
zones
aid
whether
philosophy-ethics
determine
way
resolved
agreed
open
Global / Unspecified, Global
Persistent dizziness and balance problems can severely affect quality of life, yet treatment for many chronic cases remains limited and inconsistent. A more reliable, targeted treatment approach remains undeveloped.
health-biology
global-unspecified
cases
chronic
haven
found
effective
way
treat
vertigo
treatment
remains
whether
philosophy-ethics
mathematics-logic
resolved
determine
don
open
Global / Unspecified, Global
Chronic stress is linked to heart disease, digestive problems, and other physical illnesses, but why some people are more vulnerable to these effects than others isn't fully explained. Understanding this could improve both prevention and treatment.
health-biology
global-unspecified
fully
chronic
stress
physical
some
people
others
yet
understand
leads
whether
philosophy-ethics
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Even with strict sterile procedures, a portion of surgical patients still develop infections afterward, extending recovery and sometimes causing serious complications. Reducing this risk further remains an ongoing surgical challenge.
health-biology
global-unspecified
infections
don
have
reliable
way
prevent
postoperative
meaningful
share
surgeries
philosophy-ethics
whether
resolved
determine
agreed
open
Global / Unspecified, Global
The vast majority of autoimmune disease diagnoses occur in women, and the biological reasons behind this imbalance remain only partially understood. A clearer answer could open new treatment approaches for both sexes.
mathematics-logic
global-unspecified
autoimmune
women
haven
solved
diseases
disproportionately
affect
men
vast
majority
health-biology
whether
philosophy-ethics
resolved
yet
determine
open
Global / Unspecified, Global
Highly effective hepatitis C treatments exist, but cost and healthcare access still prevent many infected people worldwide from receiving them. Expanding affordable access remains the primary barrier rather than the science itself.
health-biology
global-unspecified
effective
hepatitis
don
have
widely
available
cure
chronic
every
region
whether
philosophy-ethics
determine
way
resolved
agreed
open
Global / Unspecified, Global
Diagnosing Alzheimer's currently often requires expensive brain imaging or invasive procedures, limiting how widely early detection can be used. A cheap, accessible blood test could change how early treatment can begin.
health-biology
global-unspecified
alzheimer
blood
test
haven
found
reliable
way
detect
early-stage
simple
whether
philosophy-ethics
determine
early
don
resolved
open
Global / Unspecified, Global
COPD gradually reduces lung function over years, and while treatment can ease symptoms and slow decline, it can't reverse the underlying lung damage. A cure remains out of reach for the millions living with this condition.
health-biology
global-unspecified
cure
slow
yet
chronic
obstructive
pulmonary
disease
only
its
progression
philosophy-ethics
whether
mathematics-logic
determine
way
don
open
Global / Unspecified, Global
Even when people successfully lose significant weight, the body's biology often works to regain it over time, undermining long-term success. Understanding and countering this biological pushback remains a major open challenge.
mathematics-logic
global-unspecified
weight
regain
haven
solved
prevent
follows
successful
loss
efforts
even
whether
philosophy-ethics
resolved
determine
way
health-biology
open
Global / Unspecified, Global
Chronic pelvic pain often has no clearly identifiable cause even after extensive testing, leaving many patients with limited treatment options. A deeper understanding of its underlying causes remains needed.
health-biology
global-unspecified
chronic
pelvic
pain
patients
yet
fully
explain
treat
large
share
philosophy-ethics
whether
mathematics-logic
haven
way
open
Global / Unspecified, Global
Cervical cancer remains highly preventable through regular screening, but many women in lower-resource regions lack consistent access to the tests that catch it early. Closing this access gap could prevent large numbers of otherwise preventable deaths.
health-biology
global-unspecified
access
cervical
cancer
regions
regular
don
have
scalable
way
screen
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Many people with chronic insomnia end up relying on sleep medication for years, since non-drug treatments don't work consistently for everyone. A more effective, sustainable solution remains an open need.
health-biology
global-unspecified
chronic
insomnia
medication
haven
found
reliable
way
treat
long-term
reliance
philosophy-ethics
whether
determine
resolved
don
mathematics-logic
open
Global / Unspecified, Global
Even with modern reproductive technology, a significant share of infertility cases have no clear cause and don't respond well to existing treatments. Understanding these unexplained cases remains a major gap in reproductive medicine.
health-biology
global-unspecified
don
have
infertility
respond
treatments
cure
forms
standard
reproductive
cases
whether
philosophy-ethics
determine
resolved
way
agreed
open
Global / Unspecified, Global
Patients on dialysis often endure hours of treatment multiple times a week indefinitely, significantly affecting their quality of life. A better long-term solution, beyond transplant, remains an unmet need.
health-biology
global-unspecified
dialysis
long-term
patients
haven
solved
make
less
physically
emotionally
burdensome
whether
philosophy-ethics
mathematics-logic
way
resolved
determine
open
Global / Unspecified, Global
Diabetes can lead to serious complications like blindness, kidney failure, or amputation, but predicting which patients are most at risk early enough to intervene remains imprecise. Better prediction could allow more targeted, effective prevention.
health-biology
global-unspecified
patients
complications
diabetes
yet
reliably
predict
will
develop
severe
years
whether
philosophy-ethics
haven
mathematics-logic
way
prevent
open
Global / Unspecified, Global
Effective vaccines exist for a small number of sexually transmitted infections, but many common ones still have no vaccine available at all. Expanding vaccine coverage here could significantly reduce global disease burden.
health-biology
global-unspecified
vaccine
have
effective
sexually
transmitted
infections
don
against
beyond
few
whether
philosophy-ethics
determine
way
resolved
agreed
open
Global / Unspecified, Global
This gut infection frequently returns after treatment, partly because antibiotics disrupt the broader gut microbiome that would normally help prevent it. Better prevention of recurrence remains an unresolved clinical challenge.
health-biology
global-unspecified
prevent
recurrence
treatment
haven
found
way
clostridium
difficile
infections
antibiotic
whether
philosophy-ethics
resolved
mathematics-logic
determine
open
Global / Unspecified, Global
People with celiac disease must avoid gluten completely for life, since no treatment currently exists to let them safely consume it again. A real treatment or cure would free patients from this lifelong dietary restriction.
health-biology
global-unspecified
cure
celiac
disease
dietary
yet
only
manage
strict
avoidance
treatment
whether
philosophy-ethics
mathematics-logic
determine
haven
way
