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World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4094Total
4094Open
0Solved
9Humans
open
Global / Unspecified, Global
Some medications carry a risk of gradual liver damage that often goes undetected until routine screening or symptoms reveal significant harm has already occurred. More sensitive, earlier detection methods remain an unmet need.
health-biology
global-unspecified
liver
damage
haven
solved
detect
early
caused
long-term
medication
becomes
philosophy-ethics
whether
way
determine
resolved
don
open
Global / Unspecified, Global
Some patients with iron deficiency continue experiencing fatigue even after supplementation corrects their iron levels, suggesting other contributing factors that aren't fully understood. A more complete treatment approach remains needed.
health-biology
global-unspecified
iron
fatigue
deficiency
supplementation
don
have
effective
way
treat
chronic
whether
philosophy-ethics
resolved
determine
mathematics-logic
open
Global / Unspecified, Global
Patients with chronic lung conditions remain at ongoing risk of repeated bacterial pneumonia infections despite vaccination and preventive care. A more effective, targeted prevention approach remains needed for this vulnerable group.
health-biology
global-unspecified
vaccination
bacterial
pneumonia
patients
chronic
lung
haven
found
way
prevent
recurrence
whether
philosophy-ethics
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Surgeries designed to relieve nerve-related pain occasionally result in new or persistent pain instead, and predicting which patients are at risk remains imprecise. Better prediction and prevention could improve surgical outcomes for chronic pain patients.
health-biology
global-unspecified
pain
patients
chronic
nerve-related
surgeries
relieve
yet
fully
explain
some
philosophy-ethics
whether
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Chronic wounds, especially in diabetic patients with poor circulation, can take months to heal or never fully heal, increasing risk of serious infection. A more effective, widely accessible treatment approach remains needed.
health-biology
global-unspecified
effective
chronic
wounds
patients
poor
circulation
don
have
scalable
way
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Celiac disease can present with subtle or unusual symptoms that delay diagnosis for years in some patients, allowing ongoing intestinal damage to occur. Better, more accessible screening for atypical cases remains an unmet need.
health-biology
global-unspecified
celiac
disease
patients
symptoms
atypical
haven
solved
detect
earlier
whose
whether
philosophy-ethics
way
mathematics-logic
determine
resolved
open
Global / Unspecified, Global
Repeated ear infections in young children can sometimes lead to lasting hearing problems if not caught and treated quickly enough. More consistent early detection and treatment access remain incomplete, particularly in underserved areas.
health-biology
global-unspecified
hearing
ear
infections
early
haven
found
reliable
way
prevent
loss
whether
philosophy-ethics
determine
resolved
don
open
Global / Unspecified, Global
Most people recover fully from mononucleosis, but a smaller group experiences prolonged fatigue and other symptoms for months afterward, and this difference isn't fully explained. Better understanding could improve care for this subset of patients.
local-regional
global-unspecified
fully
people
mononucleosis
recover
yet
explain
some
develop
long-term
complications
whether
philosophy-ethics
mathematics-logic
haven
resolved
health-biology
open
Global / Unspecified, Global
A subset of patients with chronic acid reflux don't find adequate relief through standard medication, leaving surgery as one of the few remaining options. A more effective non-surgical treatment remains needed.
health-biology
global-unspecified
don
effective
chronic
acid
reflux
standard
medication
have
widely
accessible
whether
philosophy-ethics
determine
way
resolved
agreed
open
Global / Unspecified, Global
Postpartum depression is often only diagnosed once symptoms have already significantly affected a new parent's daily functioning. Earlier screening tools that catch warning signs sooner remain underdeveloped.
health-biology
global-unspecified
signs
postpartum
depression
symptoms
haven
solved
detect
early
become
severe
philosophy-ethics
whether
way
determine
don
resolved
open
Global / Unspecified, Global
TMJ disorders can cause persistent jaw pain and dysfunction that current treatments, from mouthguards to surgery, don't reliably resolve for every patient. A more effective, universal treatment approach remains undeveloped.
health-biology
global-unspecified
don
effective
jaw
pain
disorders
have
way
treat
chronic
caused
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Mental health conditions often go undiagnosed simply because they're never screened for during regular medical visits, especially in areas with limited specialist access. Making mental health screening as routine as blood pressure checks remains an unmet global health goal.
health-biology
global-unspecified
mental-health
health
mental
screening
routine
haven
solved
make
effective
part
primary
whether
philosophy-ethics
society-governance
access
remains
open
Global / Unspecified, Global
Older adults with weakened immune systems remain at ongoing risk of repeated pneumonia infections despite vaccination and preventive care, and current prevention strategies only partially reduce this risk. A more effective, targeted approach remains needed.
health-biology
global-unspecified
vaccination
pneumonia
weakened
immune
systems
yet
fully
prevent
recurrence
elderly
patients
whether
philosophy-ethics
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Some children experience repeated seizures triggered by fever, and current prevention strategies remain limited mostly to managing fever itself rather than addressing the underlying seizure susceptibility. A more effective prevention approach remains needed.
health-biology
global-unspecified
seizures
children
haven
found
reliable
way
prevent
recurrence
febrile
young
whether
philosophy-ethics
determine
resolved
mathematics-logic
open
Global / Unspecified, Global
Recurrent bacterial vaginosis affects a meaningful share of women despite standard treatment, suggesting current approaches don't fully address the underlying imbalance causing it. A more effective long-term prevention method remains needed.
philosophy-ethics
global-unspecified
fully
bacterial
vaginosis
women
yet
prevent
recurrence
experience
chronically
recurrent
whether
health-biology
mathematics-logic
way
resolved
haven
open
Global / Unspecified, Global
Some patients experience persistent fatigue for months after major surgery that goes beyond typical recovery time, and the reasons for this aren't fully understood. Better prevention and treatment of post-surgical fatigue remains an underexplored area.
health-biology
global-unspecified
fatigue
major
surgery
don
have
effective
way
prevent
chronic
sometimes
philosophy-ethics
whether
resolved
determine
agreed
open
Global / Unspecified, Global
This disfiguring and disabling condition continues to affect millions in tropical regions, and while some treatments exist, access remains inconsistent and the underlying infection prevention needs further improvement. Closing this gap remains an ongoing global health priority.
health-biology
global-unspecified
remains
regions
haven
found
effective
affordable
way
treat
elephantiasis
all
whether
philosophy-ethics
mathematics-logic
resolved
determine
don
open
Global / Unspecified, Global
High blood pressure can silently damage the kidneys over years before any symptoms appear, and by the time damage is detected, it's often already significant. Earlier, more sensitive detection methods remain an unmet need.
health-biology
global-unspecified
damage
high
blood
pressure
don
have
reliable
way
detect
early
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Extended antibiotic use can disrupt gut bacteria in ways that cause lasting digestive problems for some patients, even after the antibiotics are no longer needed. Better protection of the gut microbiome during necessary antibiotic treatment remains undeveloped.
health-biology
global-unspecified
antibiotic
digestive
yet
fully
prevent
sometimes
follow
long-term
gut
extended
whether
philosophy-ethics
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Standard gestational diabetes screening often happens later in pregnancy and can be logistically difficult to access in under-resourced areas, delaying diagnosis and management. Earlier, more accessible screening remains an unmet need.
health-biology
global-unspecified
gestational
diabetes
earlier
pregnancy
don
have
effective
scalable
way
detect
philosophy-ethics
whether
determine
resolved
agreed
