World Solve — A living repository of problems worth solving.

Next-generation vaccine platforms must be ready to respond within weeks to new threats.

open Global / Unspecified, Global

mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.

must next generation vaccine platforms health-biology

WS02038 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02038 Title: Next-generation vaccine platforms must be ready to respond within weeks to new threats. URL: https://www.worldsolve.org/index.php?api=problem&id=2038

Next-generation vaccine platforms must be ready to respond within weeks to new threats. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.

next must generation vaccine platforms health-biology

WS02039 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02039 Title: Next-generation vaccine platforms must be ready to respond within weeks to new threats. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2039

Long COVID and post-viral syndromes may remain a significant burden into the 2030s.

open Global / Unspecified, Global

Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.

long covid post viral syndromes health-biology

WS02040 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02040 Title: Long COVID and post-viral syndromes may remain a significant burden into the 2030s. URL: https://www.worldsolve.org/index.php?api=problem&id=2040

Long COVID and post-viral syndromes may remain a significant burden into the 2030s. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.

long covid post viral syndromes health-biology

WS02041 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02041 Title: Long COVID and post-viral syndromes may remain a significant burden into the 2030s. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2041

Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease.

open Global / Unspecified, Global

Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.

will pollution urbanisation drive new climate-environment

WS02042 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02042 Title: Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease. URL: https://www.worldsolve.org/index.php?api=problem&id=2042

Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.

will pollution urbanisation drive new climate-environment

WS02043 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02043 Title: Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2043

Food-system transformations will reshape human microbiomes and metabolic health.

open Global / Unspecified, Global

Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.

will metabolic food system transformations health-biology

WS02044 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02044 Title: Food-system transformations will reshape human microbiomes and metabolic health. URL: https://www.worldsolve.org/index.php?api=problem&id=2044

Food-system transformations will reshape human microbiomes and metabolic health. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.

will metabolic food system transformations health-biology

WS02045 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02045 Title: Food-system transformations will reshape human microbiomes and metabolic health. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2045

Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment.

open Global / Unspecified, Global

Resistance genes move through soil, water, and food chains, making hospital-focused interventions insufficient. One-Health regulatory frameworks and monitoring tools are required.

antibiotic stewardship will need extend climate-environment

WS02046 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02046 Title: Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment. URL: https://www.worldsolve.org/index.php?api=problem&id=2046

Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Resistance genes move through soil, water, and food chains, making hospital-focused interventions insufficient. One-Health regulatory frameworks and monitoring tools are required.

antibiotic stewardship will need extend climate-environment

WS02047 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02047 Title: Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2047

New cancer therapies will demand better real-world data to understand long-term outcomes.

open Global / Unspecified, Global

Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.

therapies new cancer will demand climate-environment

WS02048 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02048 Title: New cancer therapies will demand better real-world data to understand long-term outcomes. URL: https://www.worldsolve.org/index.php?api=problem&id=2048

New cancer therapies will demand better real-world data to understand long-term outcomes. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.

data therapies new cancer will climate-environment

WS02049 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02049 Title: New cancer therapies will demand better real-world data to understand long-term outcomes. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2049

Multi-morbidity will become the norm for older adults.

open Global / Unspecified, Global

By 2040, many patients will have multiple chronic conditions with overlapping treatments and risks. Care orchestration tools and polypharmacy-optimisation systems are needed.

will multi morbidity become norm other

WS02050 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02050 Title: Multi-morbidity will become the norm for older adults. URL: https://www.worldsolve.org/index.php?api=problem&id=2050

Multi-morbidity will become the norm for older adults. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

By 2040, many patients will have multiple chronic conditions with overlapping treatments and risks. Care orchestration tools and polypharmacy-optimisation systems are needed.

will multi morbidity become norm other

WS02051 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02051 Title: Multi-morbidity will become the norm for older adults. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2051

Health workforce shortages and burnout will grow without new models of care.

open Global / Unspecified, Global

Demand will outpace supply of clinicians unless task-shifting, automation, and new professions emerge. Workforce-planning analytics and training platforms can support transitions.

workforce will new health shortages technology-computing

WS02052 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02052 Title: Health workforce shortages and burnout will grow without new models of care. URL: https://www.worldsolve.org/index.php?api=problem&id=2052

Health workforce shortages and burnout will grow without new models of care. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Demand will outpace supply of clinicians unless task-shifting, automation, and new professions emerge. Workforce-planning analytics and training platforms can support transitions.

workforce will new health shortages technology-computing

WS02053 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02053 Title: Health workforce shortages and burnout will grow without new models of care. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2053

Climate-linked displacement will create new health-service needs for migrants.

open Global / Unspecified, Global

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

health will climate linked displacement health-biology

WS02054 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02054 Title: Climate-linked displacement will create new health-service needs for migrants. URL: https://www.worldsolve.org/index.php?api=problem&id=2054

Climate-linked displacement will create new health-service needs for migrants. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

health will climate linked displacement health-biology

WS02055 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02055 Title: Climate-linked displacement will create new health-service needs for migrants. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2055

Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders.

open Global / Unspecified, Global

Pervasive digital platforms may exacerbate sleep, focus, and mood problems. New prevention strategies, digital hygiene tools, and regulatory frameworks will be needed.

digital will global mental health technology-computing

WS02056 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02056 Title: Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders. URL: https://www.worldsolve.org/index.php?api=problem&id=2056

Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders. This variant focuses on data infrastructure and measurement challenges over the next two decades.

open Global / Unspecified, Global

Pervasive digital platforms may exacerbate sleep, focus, and mood problems. New prevention strategies, digital hygiene tools, and regulatory frameworks will be needed.

infrastructure digital will global mental technology-computing

WS02057 · Logged by Ian Patel on 2026-07-22T20:40:00Z · Horizon: 10-20 years · Working on: 0

Citation ID: WS02057 Title: Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders. This variant focuses on data infrastructure and measurement challenges over the next two decades. URL: https://www.worldsolve.org/index.php?api=problem&id=2057

What World Solve is

Next-generation vaccine platforms must be ready to respond within weeks to new threats.

Next-generation vaccine platforms must be ready to respond within weeks to new threats. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Long COVID and post-viral syndromes may remain a significant burden into the 2030s.

Long COVID and post-viral syndromes may remain a significant burden into the 2030s. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease.

Urbanisation will drive new patterns of injury, pollution exposure, and lifestyle disease. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Food-system transformations will reshape human microbiomes and metabolic health.

Food-system transformations will reshape human microbiomes and metabolic health. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment.

Antibiotic stewardship will need to extend beyond hospitals into agriculture and environment. This variant focuses on data infrastructure and measurement challenges over the next two decades.

New cancer therapies will demand better real-world data to understand long-term outcomes.

New cancer therapies will demand better real-world data to understand long-term outcomes. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Multi-morbidity will become the norm for older adults.

Multi-morbidity will become the norm for older adults. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Health workforce shortages and burnout will grow without new models of care.

Health workforce shortages and burnout will grow without new models of care. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Climate-linked displacement will create new health-service needs for migrants.

Climate-linked displacement will create new health-service needs for migrants. This variant focuses on data infrastructure and measurement challenges over the next two decades.

Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders.

Global mental-health infrastructure will struggle to keep pace with rising digital addiction and attention disorders. This variant focuses on data infrastructure and measurement challenges over the next two decades.