Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
A subset of patients develop long-lasting pain after surgeries that are usually uncomplicated for most people, and the biological reason for this difference isn't fully understood. Better prediction and prevention could reduce this often overlooked outcome.
mathematics-logic
global-unspecified
fully
people
develop
pain
haven
found
way
explain
some
chronic
whether
philosophy-ethics
health-biology
resolved
determine
open
Global / Unspecified, Global
Hormone-related migraines can be particularly difficult to prevent using standard migraine treatments, leaving affected patients with limited effective options. A more targeted prevention approach remains needed.
health-biology
global-unspecified
prevent
migraines
patients
yet
fully
recurrence
triggered
hormonal
changes
some
whether
philosophy-ethics
way
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
While uncommon, some patients experience hiccups that persist for weeks or longer, disrupting sleep, eating, and daily life, and effective treatment options remain limited. A more reliable treatment approach for these rare cases remains undeveloped.
health-biology
global-unspecified
effective
hiccups
persist
rare
cases
don
have
way
treat
chronic
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Even when Lyme disease is caught and treated early, a portion of patients still develop lasting symptoms, and doctors don't fully understand why treatment doesn't fully resolve the illness in every case. Solving this could improve outcomes for a currently underserved group of patients.
health-biology
global-unspecified
fully
patients
develop
lyme
disease
early
treatment
yet
explain
some
philosophy-ethics
whether
mathematics-logic
haven
resolved
way
open
Global / Unspecified, Global
Hair loss after childbirth is common and usually temporary, but effective treatments to speed recovery or reduce severity remain limited. While not medically dangerous, better options could ease a common and distressing postpartum experience.
health-biology
global-unspecified
effective
postpartum
hair
loss
don
have
widely
accessible
way
treat
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Long-term use of some widely available pain medications can gradually damage kidney function, often without obvious symptoms until damage is significant. Better awareness and prevention methods remain incompletely applied.
health-biology
global-unspecified
damage
long-term
kidney
pain
medications
haven
solved
prevent
caused
certain
whether
philosophy-ethics
way
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Chronic fatigue syndrome is diagnosed in women considerably more often than men, and the biological or social reasons behind this imbalance remain only partly understood. A clearer answer could improve diagnosis and treatment for both sexes.
mathematics-logic
global-unspecified
chronic
fatigue
syndrome
women
men
yet
fully
explain
affects
frequently
whether
philosophy-ethics
health-biology
haven
resolved
open
Global / Unspecified, Global
Persistent dizziness linked to inner ear problems can be difficult to diagnose precisely and treat effectively, leaving many patients with ongoing symptoms. A more reliable, targeted treatment approach remains undeveloped.
health-biology
global-unspecified
treat
dizziness
inner
ear
patients
haven
found
effective
way
chronic
whether
philosophy-ethics
determine
resolved
mathematics-logic
don
open
Global / Unspecified, Global
Some patients experience ongoing digestive issues after gallbladder removal, a very common surgery, and current understanding of why this happens in some but not others remains incomplete. Better prevention or treatment of these complications remains needed.
health-biology
global-unspecified
digestive
complications
gallbladder
removal
surgery
yet
fully
prevent
follow
some
whether
philosophy-ethics
mathematics-logic
haven
resolved
way
open
Global / Unspecified, Global
Many children with obesity go on to develop related health issues as adults, and current interventions haven't proven consistently effective at reversing childhood obesity at a population scale. A more effective, scalable approach remains an urgent unmet need.
health-biology
global-unspecified
effective
obesity
scalable
childhood
related
don
have
way
treat
leads
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Resistant malaria strains have emerged in certain regions and are gradually spreading, threatening to undermine decades of progress against the disease. Coordinated, faster response to contain resistance before it spreads further remains incomplete.
health-biology
global-unspecified
malaria
haven
solved
prevent
spread
drug-resistant
parasites
borders
resistant
strains
whether
philosophy-ethics
way
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Pelvic floor issues after childbirth can cause long-term discomfort and functional problems that current treatment options don't always fully resolve. A more effective, widely accessible treatment approach remains needed.
health-biology
global-unspecified
fully
pelvic
floor
yet
treat
chronic
dysfunction
affecting
significant
share
whether
philosophy-ethics
way
mathematics-logic
resolved
haven
open
Global / Unspecified, Global
Children with poorly controlled asthma can experience lasting reductions in lung function as adults, even if their symptoms improve over time. Preventing this long-term damage remains an incomplete area of pediatric respiratory care.
health-biology
global-unspecified
long-term
lung
asthma
don
have
effective
way
prevent
effects
childhood
whether
philosophy-ethics
resolved
determine
agreed
open
Global / Unspecified, Global
Subtle cognitive changes often precede a formal dementia diagnosis by years, but current screening tools aren't sensitive enough to reliably catch this earliest stage. Better early detection could open the door to earlier, more effective intervention.
health-biology
global-unspecified
early
cognitive
haven
found
reliable
way
detect
decline
adults
becomes
whether
philosophy-ethics
determine
resolved
don
open
Global / Unspecified, Global
Some childhood food allergies resolve naturally over time while others persist for life, and predicting which pattern a given child will follow remains largely uncertain. A clearer understanding could guide better long-term management.
health-biology
global-unspecified
some
food
allergies
while
others
yet
fully
explain
children
outgrow
whether
philosophy-ethics
haven
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
This form of chronic hives has no identifiable trigger and can resist standard antihistamine treatment in a subset of patients, leaving them with few further options. A more effective treatment approach remains undeveloped.
health-biology
global-unspecified
effective
chronic
resist
standard
don
have
way
treat
cases
idiopathic
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Some children experience repeated ear infections despite standard preventive measures, leading many toward surgical intervention as the main remaining option. A more effective non-surgical prevention approach remains an open need.
health-biology
global-unspecified
ear
infections
children
haven
solved
prevent
recurrence
prone
chronic
cases
whether
philosophy-ethics
way
resolved
mathematics-logic
determine
open
Global / Unspecified, Global
Patients confined to bed for extended periods remain at risk of developing painful pressure sores despite standard prevention protocols, especially in understaffed care settings. More effective, easier-to-implement prevention methods remain needed.
health-biology
global-unspecified
pressure
patients
yet
fully
prevent
hospital-acquired
ulcers
long-term
bedridden
remain
philosophy-ethics
whether
way
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Complications during childbirth can become fatal within minutes without access to emergency care, and many regions still lack the infrastructure to respond quickly enough. Closing this gap remains one of the most urgent unmet needs in global health.
health-biology
global-unspecified
regions
access
emergency
care
don
have
scalable
way
reduce
maternal
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Tinnitus caused by underlying nerve damage is particularly difficult to treat, and current options mostly focus on management strategies like sound therapy rather than addressing the nerve issue directly. A more direct treatment remains undeveloped.
health-biology
global-unspecified
nerve
treat
tinnitus
caused
damage
haven
found
effective
widely
available
whether
philosophy-ethics
way
determine
don
resolved
