Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4094Total
4094Open
0Solved
9Humans
open
Global / Unspecified, Global
Chronic skin conditions often require lifelong management with creams and medications rather than a resolution of the underlying immune or genetic causes. A real cure, rather than continuous symptom control, remains unavailable.
health-biology
global-unspecified
chronic
skin
conditions
management
yet
fully
treat
eczema
ongoing
whether
philosophy-ethics
mathematics-logic
haven
determine
resolved
way
open
Global / Unspecified, Global
Existing treatments for hair loss can slow the process for some people but rarely reverse it completely, and the underlying biology of hair follicle loss isn't fully understood. A true prevention or reversal method remains undiscovered.
health-biology
global-unspecified
hair
loss
don
have
effective
way
prevent
caused
genetic
hormonal
whether
philosophy-ethics
resolved
determine
agreed
open
Global / Unspecified, Global
Fertility treatments like IVF help many people conceive, but success rates still drop significantly with age due to biological factors that current medicine can't fully reverse. Understanding and addressing this decline remains incomplete.
mathematics-logic
global-unspecified
fertility
age
current
treatments
haven
solved
declines
ways
only
partially
whether
philosophy-ethics
health-biology
resolved
determine
way
open
Global / Unspecified, Global
Kidney disease often advances silently for years before symptoms appear, and by the time it's caught, treatment options are limited mainly to slowing further decline. Catching and reversing it earlier remains an open medical challenge.
health-biology
global-unspecified
kidney
disease
don
have
reliable
way
prevent
progression
chronic
its
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Bone density loss often goes unnoticed until a fall causes a serious fracture, by which point significant damage has already occurred. Better early detection and prevention could avoid many of these life-altering injuries.
health-biology
global-unspecified
until
fracture
haven
found
way
stop
osteoporosis
silently
weakening
bones
whether
philosophy-ethics
determine
resolved
prevent
open
Global / Unspecified, Global
Kidney stones are painful and prone to recurring, yet prevention methods remain limited mostly to general dietary advice rather than addressing individual underlying causes. More targeted prevention could spare patients repeated painful episodes.
health-biology
global-unspecified
yet
kidney
stones
prone
reliably
prevent
recurrence
people
developing
painful
philosophy-ethics
whether
haven
way
mathematics-logic
fully
open
Global / Unspecified, Global
Drug-resistant tuberculosis requires longer, more expensive, and more toxic treatment regimens that many patients in affected regions simply can't access or complete. This keeps a preventable disease deadly in the parts of the world least equipped to fight it.
health-biology
global-unspecified
tuberculosis
treatment
don
have
affordable
widely
available
strains
resistant
standard
whether
philosophy-ethics
way
determine
resolved
agreed
open
Global / Unspecified, Global
Severe bleeding after childbirth remains one of the leading causes of maternal death worldwide, disproportionately in regions lacking access to blood transfusions and advanced medical care. Affordable, effective solutions for these settings remain limited.
health-biology
global-unspecified
settings
haven
solved
treat
postpartum
hemorrhage
effectively
low-resource
severe
bleeding
philosophy-ethics
whether
affordable
way
determine
solutions
open
Global / Unspecified, Global
Patients sometimes continue to experience pain months or years after the original injury has healed, suggesting the nervous system itself has changed in ways doctors don't fully understand. Solving this could transform treatment for chronic pain conditions.
health-biology
global-unspecified
pain
has
fully
chronic
sometimes
injury
healed
yet
explain
persists
philosophy-ethics
whether
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Lung cancer screening guidelines are generally built around smoking history, but a meaningful share of cases occur in people who never smoked at all and often go undetected until later stages. Better screening approaches for this group remain underdeveloped.
health-biology
global-unspecified
lung
cancer
people
never
smoked
don
have
scalable
way
detect
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
IBS causes chronic digestive discomfort for a significant portion of people worldwide, yet treatment options remain limited to symptom management rather than addressing root causes. The underlying biology is still not fully mapped out.
health-biology
global-unspecified
haven
found
reliable
cure
irritable
bowel
syndrome
affecting
large
share
philosophy-ethics
whether
mathematics-logic
determine
way
resolved
open
Global / Unspecified, Global
Preeclampsia can develop suddenly and seriously endanger both mother and baby, and current screening still misses many cases until symptoms are already severe. Earlier, more accurate prediction could prevent serious harm.
health-biology
global-unspecified
develop
preeclampsia
yet
accurately
predict
pregnancies
will
dangerous
complications
like
philosophy-ethics
whether
haven
mathematics-logic
resolved
way
open
Global / Unspecified, Global
Despite strict hygiene protocols, patients still frequently contract infections during hospital stays that they didn't have when they arrived. Closing this gap could save both lives and enormous healthcare costs.
health-biology
global-unspecified
have
infections
don
fully
effective
way
prevent
hospital-acquired
despite
strict
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Millions of people experience debilitating, unpredictable migraines that current treatments only partially control, and the underlying biological triggers remain incompletely understood. More precise treatment based on individual causes remains out of reach.
mathematics-logic
global-unspecified
migraines
people
haven
solved
chronic
affect
some
far
severely
others
philosophy-ethics
whether
health-biology
resolved
determine
way
open
Global / Unspecified, Global
Cartilage has very limited ability to heal itself, which is why joint damage from injury or arthritis often leads to chronic pain or eventual joint replacement. Better regeneration methods could delay or eliminate the need for many of these surgeries.
health-biology
global-unspecified
cartilage
reliably
regenerate
damaged
joints
surgery
joint
has
very
limited
whether
philosophy-ethics
haven
way
pain
chronic
open
Global / Unspecified, Global
The constant ringing or buzzing sound of tinnitus affects millions of people, and current treatments mostly help patients cope rather than eliminate the underlying cause. A real cure remains undiscovered.
health-biology
global-unspecified
cure
tinnitus
people
haven
found
works
experience
constant
ringing
buzzing
philosophy-ethics
whether
determine
resolved
mathematics-logic
way
open
Global / Unspecified, Global
Many new parents experience postpartum depression that goes undiagnosed or untreated for months, affecting both their wellbeing and their infant's early development. Faster detection and more accessible treatment remain unmet needs.
health-biology
global-unspecified
postpartum
depression
yet
reliably
treat
causes
lasting
harm
new
parents
whether
philosophy-ethics
way
haven
determine
don
open
Global / Unspecified, Global
A large share of pregnancy loss has no clearly identifiable cause, leaving expecting parents without answers or ways to prevent it happening again. Understanding these unexplained cases remains a significant gap in reproductive medicine.
health-biology
global-unspecified
prevent
cases
cause
don
have
reliable
way
miscarriages
unknown
large
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Many patients with endometriosis experience years of unexplained pain before receiving an accurate diagnosis, largely because it's difficult to detect without invasive procedures. Better, faster diagnostic tools remain a major unmet need.
health-biology
global-unspecified
endometriosis
years
haven
solved
well
enough
stop
taking
diagnose
patients
philosophy-ethics
whether
way
mathematics-logic
determine
prevent
open
Global / Unspecified, Global
Severe burn victims often face long, painful recoveries and permanent scarring because lab-grown skin grafts aren't yet fast or effective enough to fully replace damaged tissue. Faster, better regeneration methods could change burn treatment entirely.
health-biology
global-unspecified
yet
skin
fast
enough
severe
grow
functional
replacement
patients
burns
whether
philosophy-ethics
mathematics-logic
haven
fully
resolved
