We haven't found a cure for the common cold despite decades of trying.
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.
The flu virus mutates constantly, forcing a new vaccine guess every year that sometimes misses the mark. A universal flu vaccine could end this annual guessing game and prevent thousands of deaths.
Conditions like lupus, rheumatoid arthritis, and multiple sclerosis occur when the body attacks itself, and current treatments mostly suppress symptoms rather than fix the root cause. Millions live with lifelong management instead of a real cure.
Many fast-growing cities in arid regions are outpacing the water systems built to serve them, leading to shortages and rationing. Solving this needs both new infrastructure and smarter long-term water planning.
Sustainable aviation fuel and electric planes exist in early forms but remain far more expensive than traditional jet fuel. Making clean flying both effective and affordable is still an open engineering and economic problem.
Many major rivers and aquifers are being pumped or diverted faster than rainfall can replenish them, threatening long-term water security. Without better management, some regions may simply run out of accessible fresh water.
Entire island nations and coastal communities face losing their homes permanently, with no agreed international process for where they go or who helps pay for it. This is already happening, not just a future risk.
Paved surfaces send rainwater rushing into drains that quickly overflow during storms, instead of letting it soak into the ground. Cities designed to absorb water naturally would suffer far less flood damage.
Methane is a far more potent greenhouse gas than carbon dioxide in the short term, and much of it leaks unnoticed from pipelines and wells. Better detection and faster repairs could meaningfully slow near-term warming.
Droughts, floods, and shifting seasons are making traditional farming less reliable in many regions. Crops that can handle this unpredictability are essential to keeping global food supply stable.
Cement production alone accounts for a huge share of global carbon emissions, yet it remains central to nearly all construction. A low-carbon alternative that's just as strong and cheap would be one of climate policy's biggest wins.
Coral bleaching events are becoming more frequent as ocean temperatures rise, and restoration efforts are still small and slow. Without faster recovery methods, many reef ecosystems may not survive this century.
Hotter, drier conditions combined with decades of fire suppression have left forests primed to burn catastrophically. Managing this risk needs new approaches to land management, not just faster firefighting.
Fish farming was supposed to relieve pressure on wild fisheries, but many farms still rely on wild-caught fish for feed. A truly sustainable seafood system would need to break that dependency entirely.
Concrete and asphalt trap heat, turning cities into dangerous hot zones during extreme weather, especially for people without air conditioning. Redesigning cities to stay cooler is now a matter of public safety, not comfort.
Wealthy nations have historically emitted the most greenhouse gases, but poorer nations often suffer the worst climate damage. Without a fair cost-sharing system, climate justice remains mostly a talking point rather than a policy.
Current recycling methods for batteries often use harsh chemicals or produce hazardous waste of their own. A cleaner recycling process would make the growing battery industry far more sustainable.
By the time illegal logging is discovered, the trees are often already gone and the damage is done. Real-time detection and enforcement could protect forests before, not after, they disappear.
Turning seawater into drinking water is technically possible but still too energy-intensive and expensive for many water-scarce regions. Cheaper desalination could solve water shortages for millions of people.