Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4094Total
4094Open
0Solved
9Humans
Current approaches to highly selective multi-tissue senolytic therapeutics either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.
society-governance
oceania
australia
highly
selective
multi-tissue
senolytic
therapeutics
overcoming
barriers
current
approaches
either
systems
climate-environment
enabling
under
solutions
Despite recognition of its importance, reliable methods for pathways for rapidly scaling regenerative agriculture without compromising yields are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
economics-resources
africa
egypt
pathways
rapidly
scaling
regenerative
agriculture
compromising
yields
integrated
despite
recognition
climate-environment
methods
systems
society-governance
barriers
open
Argentina, South America
A persistent gap exists in realizing practical, scalable solutions for technologies enabling efficient and low-impact extraction of minerals from seawater and brines. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
south-america
argentina
technologies
enabling
efficient
low-impact
extraction
minerals
seawater
brines
deployable
persistent
solutions
systems
methods
scalable
governance
Current approaches to AI tools that accelerate scientific discovery while remaining transparent and auditable either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.
society-governance
africa
rwanda
tools
accelerate
scientific
discovery
while
remaining
transparent
auditable
development
current
systems
climate-environment
enabling
approaches
solutions
Current approaches to technologies for the selective recovery of valuable materials from complex waste streams either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.
climate-environment
europe
greece
enabling
technologies
selective
recovery
valuable
materials
complex
waste
streams
robust
society-governance
systems
methods
approaches
solutions
Informal minibus and paratransit systems in Germany carry the majority of urban commuters but operate without route optimization, safety standards, or integration with formal transit planning.
mathematics-logic
europe
germany
informal
transit
systems
formalizing
improving
minibus
paratransit
carry
majority
society-governance
technology-computing
settlements
economics-resources
climate-environment
public
Achieving pathways for achieving high levels of energy efficiency in existing building stocks at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.
economics-resources
oceania
fiji
achieving
existing
pathways
high
levels
energy
efficiency
building
stocks
deployable
climate-environment
systems
society-governance
methods
designs
Despite recognition of its importance, reliable methods for education systems that equip citizens to evaluate scientific claims in a high-misinformation environment are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
social-civic-problems
asia
vietnam
education
systems
equip
citizens
evaluate
scientific
claims
high-misinformation
environment
development
climate-environment
society-governance
methods
barriers
designs
Coastal aquifers in Fiji are increasingly contaminated by saltwater intrusion driven by overextraction and rising sea levels, threatening long-term drinking water and irrigation supply.
climate-environment
oceania
fiji
aquifers
saltwater
intrusion
protecting
freshwater
coastal
increasingly
contaminated
driven
global-unspecified
water
long
whether
open
Guatemala, North America
Despite recognition of its importance, reliable methods for biotechnologies enabling the rapid production of medical countermeasures against emerging pathogens are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
health-biology
north-america
guatemala
barriers
biotechnologies
enabling
rapid
production
medical
countermeasures
against
emerging
pathogens
climate-environment
methods
systems
society-governance
high
open
United Kingdom, Europe
Despite recognition of its importance, reliable methods for architectural innovations that make high-density living compatible with climate resilience and well-being are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
europe
united-kingdom
architectural
innovations
make
high-density
living
compatible
climate
resilience
well-being
systemic
methods
systems
society-governance
barriers
high
open
Papua New Guinea, Oceania
Organic waste makes up a large share of landfilled municipal waste in Papua New Guinea, generating methane emissions that could be avoided with accessible composting infrastructure.
climate-environment
oceania
papua-new-guinea
waste
organic
composting
infrastructure
papua
new
guinea
diverting
landfills
makes
global-unspecified
cities
systems
plastic
recycling
A persistent gap exists in realizing practical, scalable solutions for closed-loop neuromodulation adapting to individual circuit dynamics. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
africa
ethiopia
closed-loop
neuromodulation
adapting
individual
circuit
dynamics
overcoming
barriers
persistent
gap
solutions
systems
scalable
methods
practical
Remote communities in Nigeria are often the last to receive formal disaster response, making locally trained first-responder networks essential but currently under-resourced.
social-civic-problems
africa
nigeria
disaster
response
remote
building
community-level
capacity
areas
communities
often
island
economics-resources
health-biology
society-governance
A persistent gap exists in realizing practical, scalable solutions for methods for measuring and improving the quality of democratic deliberation at scale. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
africa
zambia
practical
methods
measuring
improving
quality
democratic
deliberation
scale
realization
persistent
solutions
systems
scalable
governance
enabling
open
United States, North America
Coastal communities in United States face progressive land loss from sea-level rise, but planned relocation efforts lack frameworks for preserving livelihoods, land rights, and cultural continuity during resettlement.
economics-resources
north-america
united-states
coastal
communities
sea-level
rise
united
states
relocating
threatened
land
face
climate-environment
fishing
sea
level
global-unspecified
A persistent gap exists in realizing practical, scalable solutions for governance frameworks for the ethical use of predictive analytics in criminal justice and social services. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
asia
south-korea
governance
frameworks
ethical
predictive
analytics
criminal
justice
social
services
overcoming
solutions
systems
methods
scalable
ensuring
Despite recognition of its importance, reliable methods for methods for assessing the social equity impacts of different climate mitigation and adaptation strategies are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
europe
germany
methods
assessing
social
equity
impacts
different
climate
mitigation
adaptation
strategies
systems
society-governance
enabling
solutions
barriers
open
Ecuador, South America
Despite recognition of its importance, reliable methods for permafrost carbon abrupt-release early warning models are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
south-america
ecuador
models
permafrost
carbon
abrupt-release
early
warning
development
despite
recognition
its
methods
systems
society-governance
barriers
designs
Current approaches to non-invasive continuous monitoring of multiple chronic disease biomarkers either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.
health-biology
africa
mozambique
non-invasive
continuous
monitoring
multiple
chronic
disease
biomarkers
deployable
technologies
current
society-governance
systems
climate-environment
enabling
approaches
