World Solve

Despite recognition of its importance, reliable methods for predictive models of compound climate-health risks at neighborhood resolution are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for methods for assessing the effectiveness of different approaches to climate adaptation and resilience are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for architectural and planning approaches that make cities more walkable and less car-dependent are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for designs for energy systems that integrate high shares of variable renewables with high reliability creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for regenerative approaches to reverse age-related decline in muscle and cognition are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for seismicity-safe large-scale managed aquifer recharge methods are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for surveillance and response systems for antimicrobial resistance that function across borders are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for governance frameworks preventing the concentration of power through advanced surveillance technologies are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for therapies targeting the biology of multimorbidity rather than single diseases are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for open standards for interoperable climate and biodiversity monitoring data are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for evidence frameworks for sequencing post-conflict institutional recovery are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for technologies for selective removal of persistent organic pollutants from water bodies are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving high-temperature stable thermoelectrics with ZT above 3 at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

The absence of robust, context-adapted solutions for institutional designs for managing the global commons of the high seas and outer space creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for biotechnologies enabling the production of pharmaceuticals and fine chemicals from renewable feedstocks are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for materials and processes for recycling complex multi-material products at high purity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for affordable methods for detecting and treating the major causes of childhood undernutrition are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for low-bandwidth digital tools that deliver high-quality education in connectivity-poor areas. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for platform technologies for 30-day zoonotic antiviral response are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for biotechnologies enabling the rapid development of vaccines against unknown future pathogens are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.