World Solve

Bacteria evolve resistance faster than new antibiotics are being developed and approved, creating a widening treatment gap. Without new approaches, once-treatable infections could become far deadlier again.

A small number of people show natural resistance to certain infections or conditions, and understanding why could reveal entirely new treatment approaches. This resistance remains only partially understood at a genetic level.

Hotter, drier conditions combined with decades of fire suppression have left forests primed to burn catastrophically. Managing this risk needs new approaches to land management, not just faster firefighting.

Current approaches to real-time monitoring and response systems for industrial chemical and oil spill events either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for education approaches that build the capacity for systems thinking and long-term decision making creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to designs for digital identity and credential systems that protect privacy and prevent exclusion either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to scalable restoration of degraded dryland ecosystems under intensifying aridity either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to selective critical-ion extraction from low-grade brines either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for education systems that equip learners with the skills needed for a circular and regenerative economy creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to methods for assessing the cumulative impacts of climate change and other stressors on human health either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for open-source platforms for collaborative climate model development and evaluation creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to point-of-care multiplex diagnostics for priority AMR pathogens either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Achieving institutional designs that increase the political feasibility of ambitious climate policies at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

The absence of robust, context-adapted solutions for galactic cosmic ray shielding without prohibitive mass penalties creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to institutional arrangements that accelerate the diffusion of proven climate solutions either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to circular economy systems that eliminate leakage of plastics into the environment either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to interventions that reduce the transmission of vector-borne diseases under changing climate either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Achieving systems for continuous verification of nuclear non-proliferation commitments at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Current approaches to methods for restoring soil biodiversity and function after intensive conventional agriculture either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to methods for restoring the ecological function of rivers fragmented by dams and infrastructure either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.