Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Brazil, South America
Develop point-of-care diagnostics for invasive and drug-resistant fungal infections, especially among immunocompromised patients in regions lacking advanced laboratories.
health-biology
south-america
brazil
diagnostics
fungal
infections
low-cost
resistant
standard
treatment
develop
point-of-care
invasive
global-unspecified
whether
philosophy-ethics
haven
mathematics-logic
Develop surveillance and affordable safety protocols for dialysis delivered in fragmented private and informal systems, where contamination and equipment reuse may go undocumented.
society-governance
africa
egypt
informal
dialysis
mapping
unsafe
practices
develop
surveillance
affordable
safety
protocols
systems
settlements
economics-resources
technology-computing
without
Create accurate, validated screening tools that detect dangerous neonatal bilirubin levels in homes and rural clinics without requiring expensive laboratory equipment.
health-biology
asia
pakistan
neonatal
affordable
jaundice
detection
outside
hospitals
create
accurate
validated
screening
global-unspecified
whether
philosophy-ethics
haven
detect
Design clinically reliable decision-support tools using basic vitals, history, and low-cost tests to identify high-risk pregnancies before preventable postpartum hemorrhage occurs.
health-biology
asia
bangladesh
hemorrhage
predicting
maternal
risk
under-equipped
clinics
design
clinically
reliable
decision-support
postpartum
reducing
global-unspecified
philosophy-ethics
whether
Create field-deployable chemical verification methods that pharmacies, regulators, and patients can use to distinguish authentic cancer drugs from counterfeit or degraded products.
health-biology
africa
nigeria
supply-chain
verification
counterfeit
rapid
oncology
medicines
informal
supply
chains
create
field-deployable
global-unspecified
economics-resources
whether
philosophy-ethics
Develop tamper-resistant, ultra-low-cost monitoring and backup cooling systems for vaccines, insulin, biologics, and diagnostic reagents where electricity failures are frequent.
health-biology
asia
india
monitoring
cold-chain
heat-sensitive
medicines
unreliable
power
grids
develop
tamper-resistant
ultra-low-cost
systems
society-governance
climate-environment
continuous
technologies
Build low-cost metagenomic and biosensor systems that identify emerging resistance genes in sewage networks early enough for hospitals and public-health agencies to alter treatment protocols.
health-biology
resistance
detecting
antimicrobial
wastewater
clinical
outbreaks
build
low-cost
metagenomic
biosensor
systems
society-governance
health
environmental
early
climate-environment
Despite recognition of its importance, reliable methods for integrated wildlife-livestock-human zoonotic spillover surveillance are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
africa
ghana
integrated
wildlife-livestock-human
zoonotic
spillover
surveillance
development
despite
recognition
its
importance
methods
systems
barriers
society-governance
designs
Registering a new business in Germany often requires navigating multiple disconnected agencies with redundant paperwork, discouraging formalization of small enterprises.
climate-environment
europe
germany
business
reducing
bureaucratic
delay
registration
processes
registering
new
often
africa
south
ukraine
poland
open
Paraguay, South America
A persistent gap exists in realizing practical, scalable solutions for distributed methane leak detection and auto-mitigation systems. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
south-america
paraguay
systems
distributed
methane
leak
detection
auto-mitigation
field-ready
persistent
gap
exists
solutions
climate-environment
methods
ensuring
governance
Achieving early warning systems for social unrest linked to climate and resource stress at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.
climate-environment
africa
tanzania
systems
early
warning
social
unrest
linked
climate
resource
stress
robust
society-governance
economics-resources
methods
technology-computing
solutions
Governments and households in disaster-prone regions of India lack pre-arranged financing mechanisms, forcing reliance on slow post-disaster aid appeals rather than rapid, budgeted recovery funds.
society-governance
asia
india
recovery
financing
disaster-prone
regions
designing
affordable
insurance-linked
governments
households
disaster
prone
economics-resources
climate-environment
community
scale
Standard trauma-focused therapy models are frequently misaligned with the cultural frameworks of displaced populations from Global, reducing engagement and effectiveness among refugees receiving care abroad.
climate-environment
therapy
displaced
populations
building
culturally
adapted
protocols
standard
trauma-focused
global-unspecified
whether
philosophy-ethics
open
Paraguay, South America
A persistent gap exists in realizing practical, scalable solutions for education and training systems that prepare populations for climate-driven livelihood transitions. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.
society-governance
south-america
paraguay
solutions
education
training
systems
prepare
populations
climate-driven
livelihood
transitions
systemic
methods
climate-environment
scalable
ensuring
designs
Despite recognition of its importance, reliable methods for behavioral and structural interventions reducing food loss in tropical value chains are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
south-america
peru
behavioral
structural
interventions
reducing
food
loss
tropical
value
chains
integrated
methods
systems
barriers
society-governance
designs
Despite recognition of its importance, reliable methods for institutional arrangements that improve coordination between health climate and development sectors are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.
climate-environment
europe
france
institutional
arrangements
improve
coordination
between
health
climate
development
sectors
integrated
society-governance
methods
systems
designs
barriers
open
Solomon Islands, Oceania
Current approaches to pathways for achieving high levels of circularity in the plastics and packaging sectors either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.
climate-environment
oceania
solomon-islands
pathways
achieving
high
levels
circularity
plastics
packaging
sectors
development
current
society-governance
systems
enabling
approaches
solutions
open
United States, North America
The absence of robust, context-adapted solutions for institutional designs that make long-term infrastructure investment politically durable creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.
society-governance
north-america
united-states
durable
institutional
designs
make
long-term
infrastructure
investment
politically
practical
realization
systems
solutions
climate-environment
methods
enabling
open
Ecuador, South America
Achieving systems ensuring the safety and reliability of AI systems used in critical infrastructure control at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.
economics-resources
south-america
ecuador
systems
ensuring
safety
reliability
critical
infrastructure
control
breakthrough
approaches
achieving
society-governance
climate-environment
technology-computing
mathematics-logic
philosophy-ethics
Manufacturers in Poland largely dispose of byproducts that could be inputs for other industries, but there is no matchmaking infrastructure connecting waste streams to potential users.
climate-environment
europe
poland
byproducts
building
industrial
symbiosis
networks
reuse
manufacturing
manufacturers
largely
global-unspecified
waste
africa
