What World Solve is
World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.
For builders
Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.
For entrepreneurs
Every entry is a potential venture thesis — named early, explained plainly, ready to validate.
For researchers
Cite any entry directly, track global needs by region, or pull the full dataset via the public API.
1355 total logged
1355 still open
0 marked solved
7 registered profiles
We don't fully understand why some people develop severe allergic reactions to foods that are harmless to most others.
open
Global / Unspecified, Global
Food allergies have been rising for reasons researchers still can't fully explain, and existing treatments mostly manage symptoms after exposure rather than removing the risk entirely. A true prevention or cure remains elusive.
Citation ID: WS00466
Title: We don't fully understand why some people develop severe allergic reactions to foods that are harmless to most others.
URL: https://www.worldsolve.org/index.php?api=problem&id=466
We haven't developed a reliable way to detect ovarian cancer early, when it's most treatable.
open
Global / Unspecified, Global
Ovarian cancer is often called a silent disease because symptoms don't appear until it has advanced significantly. Early detection tools remain far behind those available for other common cancers.
Citation ID: WS00465
Title: We haven't developed a reliable way to detect ovarian cancer early, when it's most treatable.
URL: https://www.worldsolve.org/index.php?api=problem&id=465
We can't yet reverse liver damage caused by chronic disease before it requires a transplant.
open
Global / Unspecified, Global
Fatty liver disease and cirrhosis often progress silently until liver function is severely compromised, leaving transplant as the only real option for many patients. A way to reverse earlier-stage liver damage could prevent countless transplants.
Citation ID: WS00464
Title: We can't yet reverse liver damage caused by chronic disease before it requires a transplant.
URL: https://www.worldsolve.org/index.php?api=problem&id=464
We don't have a scalable cure for sickle cell disease available to most patients who need it.
open
Global / Unspecified, Global
Emerging gene therapies show promise but remain extremely expensive and inaccessible to the vast majority of people living with sickle cell disease worldwide, especially in Africa where it's most common. Making a real cure affordable and available remains unsolved.
Citation ID: WS00463
Title: We don't have a scalable cure for sickle cell disease available to most patients who need it.
URL: https://www.worldsolve.org/index.php?api=problem&id=463
We haven't found a way to detect pancreatic cancer early enough to treat it successfully in most cases.
open
Global / Unspecified, Global
Pancreatic cancer often shows no clear symptoms until it has already spread, making it one of the deadliest common cancers. An affordable early screening method could dramatically improve survival rates.
Citation ID: WS00462
Title: We haven't found a way to detect pancreatic cancer early enough to treat it successfully in most cases.
URL: https://www.worldsolve.org/index.php?api=problem&id=462
We can't yet stop the global rise of antibiotic-resistant infections through new drug development alone.
open
Global / Unspecified, Global
Bacteria evolve resistance faster than new antibiotics are being developed and approved, creating a widening treatment gap. Without new approaches, once-treatable infections could become far deadlier again.
Citation ID: WS00461
Title: We can't yet stop the global rise of antibiotic-resistant infections through new drug development alone.
URL: https://www.worldsolve.org/index.php?api=problem&id=461
We don't have a reliable cure for chronic fatigue syndrome.
open
Global / Unspecified, Global
Millions of people live with persistent, disabling fatigue that doctors struggle to diagnose clearly or treat effectively. The underlying biology remains poorly understood despite decades of patient reports.
Citation ID: WS00460
Title: We don't have a reliable cure for chronic fatigue syndrome.
URL: https://www.worldsolve.org/index.php?api=problem&id=460
We haven't solved why some infections turn into chronic, long-term illness in certain people but not others.
open
Global / Unspecified, Global
Conditions like long COVID and chronic Lyme disease affect some patients severely while others recover fully from the same initial infection. Understanding this difference could unlock treatments for currently unexplained chronic illness.
Citation ID: WS00459
Title: We haven't solved why some infections turn into chronic, long-term illness in certain people but not others.
URL: https://www.worldsolve.org/index.php?api=problem&id=459
We can't reliably predict who will respond well to a given cancer treatment before trying it.
open
Global / Unspecified, Global
Patients often go through months of chemotherapy or other treatments before doctors learn whether it's actually working for their specific cancer. Better predictive tools could spare patients ineffective treatment and its side effects.
Citation ID: WS00458
Title: We can't reliably predict who will respond well to a given cancer treatment before trying it.
URL: https://www.worldsolve.org/index.php?api=problem&id=458
We don't have an effective vaccine against most types of cancer.
open
Global / Unspecified, Global
Some cancer vaccines exist for specific cases, but a broadly effective vaccine that prevents or treats most cancers remains out of reach. This could shift cancer from a disease we treat to one we largely prevent.
Citation ID: WS00457
Title: We don't have an effective vaccine against most types of cancer.
URL: https://www.worldsolve.org/index.php?api=problem&id=457
We can't yet regenerate damaged heart muscle after a heart attack.
open
Global / Unspecified, Global
Once heart tissue dies from lack of oxygen, the body replaces it with scar tissue that can't pump blood effectively. Restoring the heart's ability to heal itself would transform recovery for millions of survivors.
Citation ID: WS00456
Title: We can't yet regenerate damaged heart muscle after a heart attack.
URL: https://www.worldsolve.org/index.php?api=problem&id=456
We still don't have a cure for type 1 diabetes, only lifelong insulin management.
open
Global / Unspecified, Global
The immune system destroys insulin-producing cells for reasons we don't fully understand, forcing patients into decades of careful daily management. A real cure would end this instead of just controlling it.
Citation ID: WS00455
Title: We still don't have a cure for type 1 diabetes, only lifelong insulin management.
URL: https://www.worldsolve.org/index.php?api=problem&id=455
Many governments still lack a formal, transparent process for deciding which laws to actually enforce given limited resources.
open
Global / Unspecified, Global
With finite budgets and staff, agencies inevitably choose which laws to prioritize enforcing, but this decision-making is often informal and opaque rather than publicly explained. This can lead to uneven, seemingly arbitrary enforcement.
Citation ID: WS00454
Title: Many governments still lack a formal, transparent process for deciding which laws to actually enforce given limited resources.
URL: https://www.worldsolve.org/index.php?api=problem&id=454
There's no reliable process in many governance systems for citizens to hold regulators accountable for regulatory failures.
open
Global / Unspecified, Global
When a regulator fails to catch a problem, like an unsafe product or a financial scandal, there's often no clear path for citizens to hold the regulator itself accountable for that failure. This leaves oversight bodies with limited pressure to actually improve.
Citation ID: WS00453
Title: There's no reliable process in many governance systems for citizens to hold regulators accountable for regulatory failures.
URL: https://www.worldsolve.org/index.php?api=problem&id=453
Government pension systems for public employees in many countries are underfunded relative to future obligations.
open
Global / Unspecified, Global
Promises made to public workers decades ago about retirement benefits sometimes weren't matched with enough funding set aside to actually cover them. This leaves future governments facing financial strain that current officials often avoid addressing.
Citation ID: WS00452
Title: Government pension systems for public employees in many countries are underfunded relative to future obligations.
URL: https://www.worldsolve.org/index.php?api=problem&id=452
There's no consistent international mechanism for protecting journalists who report on corruption in their own governments.
open
Global / Unspecified, Global
Journalists investigating government wrongdoing in many countries face harassment, legal threats, or violence with limited international protection or recourse. Stronger, coordinated protections remain largely aspirational rather than actively enforced.
Citation ID: WS00451
Title: There's no consistent international mechanism for protecting journalists who report on corruption in their own governments.
URL: https://www.worldsolve.org/index.php?api=problem&id=451
Many countries lack a clear legal process for holding former leaders accountable for actions taken while in office.
open
Global / Unspecified, Global
Some former officials effectively become immune to prosecution once they leave power, either through legal loopholes or political reluctance to pursue former leaders. This can weaken accountability for abuses of power at the very top.
Citation ID: WS00450
Title: Many countries lack a clear legal process for holding former leaders accountable for actions taken while in office.
URL: https://www.worldsolve.org/index.php?api=problem&id=450
There's no widely accepted framework for how governments should regulate their own use of predictive policing tools.
open
Global / Unspecified, Global
Software that predicts where crime might occur or who might commit it is being adopted by police departments with little independent oversight of its accuracy or fairness. This leaves significant power in tools that haven't been thoroughly vetted for bias.
Citation ID: WS00449
Title: There's no widely accepted framework for how governments should regulate their own use of predictive policing tools.
URL: https://www.worldsolve.org/index.php?api=problem&id=449
Many governance systems still lack a clear plan for how to govern in the aftermath of a major cyberattack on public infrastructure.
open
Global / Unspecified, Global
If a significant cyberattack disabled core government systems, many countries lack a clearly rehearsed plan for maintaining basic governance functions during the recovery period. This leaves a critical vulnerability largely unaddressed until it's actually tested.
Citation ID: WS00448
Title: Many governance systems still lack a clear plan for how to govern in the aftermath of a major cyberattack on public infrastructure.
URL: https://www.worldsolve.org/index.php?api=problem&id=448
Constitutional courts in some countries face pressure that undermines their ability to rule against the government.
open
Global / Unspecified, Global
When judges' careers, safety, or institutional funding depend on staying in the government's good graces, their ability to rule impartially against powerful officials can be compromised. Protecting judicial independence from this kind of pressure remains an ongoing struggle.
Citation ID: WS00447
Title: Constitutional courts in some countries face pressure that undermines their ability to rule against the government.
URL: https://www.worldsolve.org/index.php?api=problem&id=447
