massive accumulation of plastic in the oceans remains one of the most urgent challenges of our time. Systems currently in place are inadequate for the scale and complexity of the problem. A successful approach must work where resources are scarcest and demonstrate clear, measurable results. It should identify possible harms, respect local agency, and show how the solution can be maintained and expanded by the communities it is meant to serve.
massive
accumulation
plastic
oceans
implementing
climate-environment
Addressing high vehicle emissions damaging health and climate is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.
high
vehicle
emissions
damaging
health
climate-environment
Addressing people forced to sleep on the streets is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.
people
forced
sleep
streets
2030
mathematics-logic
housing that remains unaffordable for ordinary families remains one of the most urgent challenges of our time. Systems currently in place are inadequate for the scale and complexity of the problem. A successful approach must work where resources are scarcest and demonstrate clear, measurable results. It should identify possible harms, respect local agency, and show how the solution can be maintained and expanded by the communities it is meant to serve.
remains
housing
unaffordable
ordinary
families
social-civic-problems
Addressing unsafe and hazardous working conditions is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.
unsafe
hazardous
working
conditions
2030
mathematics-logic
Addressing widespread diseases caused by contaminated water is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.
widespread
diseases
caused
contaminated
water
mathematics-logic
open
Mexico, North America
As identity, payments, records, and service portals become central to state capacity, failures will produce large-scale disputes. The unresolved problem is setting up fast, fair, and trusted systems to resolve them. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
north-america
mexico
state-capacity
institutions
public
informal
settlements
creating
dispute
resolution
digital
infrastructure
fair
systems
technology-computing
governance
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. The approach must scale before formal institutions, infrastructure, and land-use systems fully catch up with population growth. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
asia
india
ai-designed
standards
proteins
rapidly
urbanizing
regions
deployment
approach
biological
technology-computing
society-governance
economics-resources
climate-environment
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The solution must produce useful coordination and accountability while minimizing collection of sensitive personal and behavioral data. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
asia
india
feedstocks
biomanufacturing
non-food
mass
surveillance
large-scale
fermentation
may
compete
food
technology-computing
economics-resources
society-governance
systems
without
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
asia
india
feedstocks
biomanufacturing
non-food
under
geopolitical
fragmentation
large-scale
fermentation
may
compete
technology-computing
economics-resources
society-governance
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
feedstocks
biomanufacturing
non-food
low-income
communities
large-scale
fermentation
may
compete
food
technology-computing
economics-resources
society-governance
systems
infrastructure
quantum
safe
Digital consultation can produce large volumes of participation while still failing to influence decisions. The challenge is creating governance processes where consultation changes outcomes and does not become symbolic theater. The challenge is especially acute in informal settlements, where legacy systems, coordination failures, and weak oversight can magnify harm.
society-governance
consultation
informal
settlements
making
public
meaningful
scale
digital
produce
large
systems
technology-computing
across
climate-environment
institutions
Political communication will increasingly include deepfakes, voice cloning, and AI-generated persuasion at scale. The challenge is developing election rules, platform standards, and enforcement systems that protect speech while limiting manipulation. The challenge is especially acute in informal settlements, where legacy systems, coordination failures, and weak oversight can magnify harm.
society-governance
asia
indonesia
informal
settlements
creating
accountable
governance
synthetic
media
elections
systems
political
technology-computing
public
climate-environment
across
without
Utility data are fragmented, pressure changes are poorly localized, and repairs compete with emergency work. Low-cost sensing, probabilistic fault localization, and outcome-based maintenance could let local operators prioritize the few failures that matter most. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with measure uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
mathematics-logic
asia
philippines
might
small
municipalities
detect
repair
leaking
public
water
networks
losses
local
actors
social-civic-problems
before
united
Vendors operate with thin margins and little historical data. Lightweight forecasting, shared cold storage, and cooperative purchasing could convert neighborhood-level signals into practical decisions without requiring enterprise software. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with allocate uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
local-regional
africa
morocco
vendors
might
informal
food
predict
daily
demand
wasting
perishable
stock
local
actors
mathematics-logic
social-civic-problems
without
The technical problem is coupled with a social allocation problem: production varies, meters may be imperfect, and residents need rules they trust. Tariff design, optimization, and transparent settlement tools could make shared generation investable. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with forecast uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
mathematics-logic
asia
india
might
apartment
blocks
share
rooftop
solar
fairly
households
consume
different
local
actors
social-civic-problems
united
reuse
open
Colombia, South America
Frontline workers often face incomplete records, unreliable connectivity, and high consequences for missed deterioration. Decision-support models must be calibrated locally, auditable, and paired with referral logistics rather than treated as standalone AI. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with verify uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
health-biology
south-america
colombia
referral
might
rural
clinics
decide
patients
need
diagnostic
equipment
scarce
local
actors
mathematics-logic
social-civic-problems
united
Teachers cannot manually inspect every error pattern, while generic adaptive apps often optimize clicks rather than mastery. Compact knowledge models and teacher-controlled workflows could make personalization affordable and pedagogically accountable. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with coordinate uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
social-civic-problems
asia
bangladesh
might
students
crowded
classrooms
receive
practice
matched
misconceptions
teachers
cannot
local
actors
mathematics-logic
united
referral
Good firms can be rejected because financial statements lag reality or assets are hard to pledge. Cash-flow inference, purchase-order verification, and risk-sharing products could widen credit while limiting fraud and over-borrowing. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with measure uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
mathematics-logic
asia
philippines
might
local
actors
small
manufacturers
price
working-capital
loans
operational
social-civic-problems
united
workers
before
independent
turn
Patients waste time visiting multiple shops, while inventory data are private and substitution rules are complex. Privacy-preserving stock signals, route optimization, and pharmacist-led protocols could reduce search costs without creating a dominant intermediary. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with route uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
mathematics-logic
asia
t-rkiye
might
neighborhood
pharmacies
coordinate
medicine
availability
during
shortages
route
patients
local
actors
social-civic-problems
united
vendors