World Solve

Current approaches to technologies enabling efficient and low-impact desalination and water treatment at various scales either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to biotechnologies enabling the production of high-value materials from captured carbon dioxide either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to real-time digital twins of entire river basins for adaptive management either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to housing and land systems that prevent displacement during climate-driven migration either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Despite recognition of its importance, reliable methods for institutional designs that make long-term investments in public health infrastructure politically sustainable are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving systems ensuring the long-term stewardship and accessibility of scientific knowledge and data at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Current approaches to interventions that improve the quality and equity of primary healthcare delivery either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Integrate agronomy, nutrition, processing, taste, markets, policy, and cultural preferences to enable adoption of resilient crops.

Establish reliable exposure measurement, causal evidence, biological mechanisms, and practical interventions for microplastics in food, water, and air.

Create validated organoid, organ-on-chip, computational, and regulatory approaches that better predict human outcomes while reducing animal use.

Build long-term evidence and mitigation systems for impacts of wind, solar, transmission, hydropower, and battery-mineral extraction on ecosystems.

Develop collection, storage, propagation, and assisted-migration strategies for native plants whose historical habitats are no longer climatically stable.

Develop modular, climate-appropriate, culturally suitable transitional housing that avoids prolonged camp conditions and can evolve into permanent homes.

Develop cost-effective seismic upgrades, risk prioritization, financing, and phased construction plans that preserve educational continuity.

Establish evidence-based tools and public-health interventions for repeated smoke exposure, especially among children, older adults, and outdoor workers.

Create clinically sound pathways, tools, and training that reduce years-long delays in diagnosis and treatment for endometriosis where specialist care is scarce.

Current approaches to pathways for achieving high levels of circularity in the plastics and packaging sectors either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for institutional designs that make long-term infrastructure investment politically durable creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to higher-order assessments valid under unrestricted AI tool access either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to methods for assessing the resilience of critical infrastructure to compound climate and cyber risks either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.