Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Thyroid problems after childbirth can cause fatigue, mood changes, and other symptoms that are sometimes mistaken for normal postpartum adjustment, delaying diagnosis. Routine, accessible screening remains inconsistently practiced.
health-biology
global-unspecified
accessible
postpartum
thyroid
don
have
widely
way
detect
treat
dysfunction
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Many patients with chronic conditions end up back in the hospital shortly after being discharged, often due to gaps in follow-up care rather than a failure of the original treatment. Better post-discharge support remains an unresolved healthcare system issue.
health-biology
global-unspecified
hospital
chronic
patients
haven
found
reliable
way
prevent
readmissions
disease
whether
philosophy-ethics
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Some diseases occur far more frequently within certain populations due to genetic factors that aren't yet fully mapped or understood. Filling this knowledge gap could lead to more targeted prevention and treatment.
health-biology
global-unspecified
yet
fully
certain
populations
diseases
explain
genetically
susceptible
specific
some
philosophy-ethics
whether
mathematics-logic
haven
resolved
prevent
open
Global / Unspecified, Global
Patients who've had one dangerous blood clot are at ongoing risk of another, and current prevention relies mainly on long-term blood thinners that carry their own risks. A more targeted, lower-risk prevention method remains needed.
health-biology
global-unspecified
blood
patients
don
have
effective
way
prevent
recurrence
clots
prone
philosophy-ethics
whether
determine
resolved
open
Global / Unspecified, Global
Many cancer survivors continue to experience pain long after their cancer treatment concludes, and this pain is often undertreated because it's assumed to have resolved along with the disease. Better long-term pain management for survivors remains an overlooked need.
health-biology
global-unspecified
pain
cancer
survivors
treatment
haven
solved
treat
chronic
has
ended
whether
philosophy-ethics
way
determine
resolved
don
open
Global / Unspecified, Global
Research shows a strong link between childhood trauma and adult physical illness, but effective, scalable prevention and early intervention remain limited. Closing this gap could improve both mental and physical health outcomes across entire populations.
health-biology
global-unspecified
physical
childhood
trauma
adult
health
yet
fully
prevent
long-term
effects
whether
philosophy-ethics
haven
mathematics-logic
society-governance
way
open
Global / Unspecified, Global
Extended time in a hospital bed, especially in intensive care, can cause significant muscle loss that affects recovery and long-term function. Better prevention methods during hospitalization remain underdeveloped.
health-biology
global-unspecified
muscle
hospital
haven
found
effective
way
prevent
wasting
caused
long
whether
philosophy-ethics
resolved
determine
open
Global / Unspecified, Global
A meaningful share of infertility cases have no identifiable cause even after thorough testing, leaving both patients and doctors without clear answers or targeted treatment. Understanding these cases better remains an open research priority.
mathematics-logic
global-unspecified
cases
infertility
yet
fully
explain
biological
causes
unexplained
meaningful
share
whether
philosophy-ethics
health-biology
haven
resolved
way
open
Global / Unspecified, Global
A subset of patients with chronic hives don't respond well to typical antihistamine treatment, leaving them with persistent, disruptive symptoms and few further options. More effective alternatives remain limited.
health-biology
global-unspecified
don
effective
treatment
chronic
hives
respond
have
widely
available
standard
whether
philosophy-ethics
determine
way
resolved
agreed
open
Global / Unspecified, Global
Childhood asthma rates have risen substantially, but why some children develop severe, persistent symptoms while others exposed to similar triggers don't remains only partly understood. A clearer answer could improve both prevention and treatment.
health-biology
global-unspecified
some
children
develop
severe
asthma
while
others
similar
don
haven
whether
philosophy-ethics
resolved
determine
mathematics-logic
way
open
Global / Unspecified, Global
Some patients continue experiencing symptoms long after completing standard treatment for Lyme disease, and doctors disagree on both the cause and the best way to treat this lingering illness. Resolving this uncertainty remains a significant unmet need.
health-biology
global-unspecified
treat
lyme
disease
symptoms
standard
treatment
yet
fully
chronic
persist
whether
philosophy-ethics
way
mathematics-logic
haven
determine
open
Global / Unspecified, Global
Many people who experience one episode of depression go on to experience another, and current treatments don't reliably prevent this recurrence. Better long-term prevention strategies remain an important gap in mental health care.
health-biology
global-unspecified
mental-health
don
prevent
recurrence
depression
episode
have
effective
way
first
experience
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Stomach cancer often causes no clear symptoms until it has progressed significantly, particularly in regions without routine screening programs. Earlier, more accessible detection could substantially improve survival outcomes.
health-biology
global-unspecified
stomach
cancer
haven
found
reliable
way
detect
early-stage
becomes
advanced
whether
philosophy-ethics
determine
resolved
don
open
Global / Unspecified, Global
Infections like Zika or cytomegalovirus can cause serious birth defects if contracted during pregnancy, and prevention options remain limited in many regions. Better vaccines or protective treatments remain needed to close this gap.
health-biology
global-unspecified
birth
defects
infections
during
pregnancy
yet
fully
prevent
caused
certain
philosophy-ethics
whether
haven
way
mathematics-logic
open
Global / Unspecified, Global
Osteoarthritis treatment currently focuses on managing pain and preserving remaining function rather than restoring lost cartilage. A regenerative treatment could transform care for one of the most common causes of chronic pain in older adults.
health-biology
global-unspecified
cartilage
causes
osteoarthritis
don
have
effective
way
reverse
loss
treatment
philosophy-ethics
whether
determine
resolved
agreed
open
United States, North America
Thousands of patients remain on transplant waiting lists that never resolve in time, largely because donor organ supply can't keep pace with demand. Alternatives like lab-grown organs remain the most promising but still unrealized solution.
local-regional
north-america
united-states
organ
patients
donor
haven
solved
make
transplants
available
relying
solely
global-unspecified
whether
philosophy-ethics
health-biology
mathematics-logic
open
Global / Unspecified, Global
Post-viral fatigue syndromes, including long COVID, leave some patients exhausted for months or years after the initial infection has cleared, and the biological mechanism remains unclear. Understanding this could unlock treatment for a currently poorly understood condition.
health-biology
global-unspecified
fatigue
long
yet
fully
explain
chronic
sometimes
follows
viral
infections
whether
philosophy-ethics
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Repeated gout attacks can cause lasting joint damage even with treatment, and prevention still relies mainly on managing uric acid levels rather than fully eliminating the underlying risk. A more definitive prevention method remains unmet.
health-biology
global-unspecified
joint
damage
gout
attacks
don
have
reliable
way
prevent
caused
whether
philosophy-ethics
resolved
determine
open
Global / Unspecified, Global
Narcolepsy causes sudden, uncontrollable sleep episodes that significantly disrupt daily life, and current treatments manage symptoms rather than address the underlying cause. A true cure remains undiscovered.
health-biology
global-unspecified
cure
narcolepsy
manage
symptoms
haven
found
way
only
its
medication
philosophy-ethics
whether
determine
mathematics-logic
don
resolved
open
Global / Unspecified, Global
This parasitic disease affects millions in tropical and subtropical regions, but effective treatment remains expensive, difficult to access, or logistically challenging for many affected communities. Closing this access gap remains unresolved.
health-biology
global-unspecified
regions
don
have
affordable
cure
leishmaniasis
available
all
endemic
remains
whether
philosophy-ethics
determine
way
resolved
agreed
