We haven't found a cure for the common cold despite decades of trying.
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
Hundreds of different viruses cause cold symptoms, making a single cure extremely difficult to develop. It remains one of medicine's most familiar yet unsolved problems.
Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.
Sustainable aviation fuel and electric planes exist in early forms but remain far more expensive than traditional jet fuel. Making clean flying both effective and affordable is still an open engineering and economic problem.
Entire island nations and coastal communities face losing their homes permanently, with no agreed international process for where they go or who helps pay for it. This is already happening, not just a future risk.
Droughts, floods, and shifting seasons are making traditional farming less reliable in many regions. Crops that can handle this unpredictability are essential to keeping global food supply stable.
Hotter, drier conditions combined with decades of fire suppression have left forests primed to burn catastrophically. Managing this risk needs new approaches to land management, not just faster firefighting.
Wealthy nations have historically emitted the most greenhouse gases, but poorer nations often suffer the worst climate damage. Without a fair cost-sharing system, climate justice remains mostly a talking point rather than a policy.
Current recycling methods for batteries often use harsh chemicals or produce hazardous waste of their own. A cleaner recycling process would make the growing battery industry far more sustainable.
By the time illegal logging is discovered, the trees are often already gone and the damage is done. Real-time detection and enforcement could protect forests before, not after, they disappear.
Turning seawater into drinking water is technically possible but still too energy-intensive and expensive for many water-scarce regions. Cheaper desalination could solve water shortages for millions of people.
Direct air capture exists, but it's still far too expensive and energy-intensive to make a dent in global emissions. Making it cheap enough to scale is one of the biggest levers left for slowing climate change.
As AI-generated accounts and bots flood social platforms, telling a real person from an automated one is getting harder. Without a trusted verification method, online trust and public discourse both suffer.
Machine translation is fast and often accurate, but it still misses jokes, idioms, and cultural context that change meaning entirely. Real cross-cultural communication needs more than word-for-word accuracy.
For decades, computer chips got faster mainly by shrinking transistors, but they're now near the smallest physically possible size. Finding a new way to keep computing power growing is an open engineering problem.
Modern software is built from thousands of smaller components, any of which could be secretly tampered with. Without full traceability, a single compromised piece can quietly infect software used by millions.
When an AI makes a harmful decision, it's often unclear whether the blame falls on the developer, the user, or the company deploying it. Without clear rules, victims of AI mistakes often have no clear path to accountability.
Fake videos and voice clones are now realistic enough to fool most people, and detection tools often lag behind the technology creating them. Left unresolved, this threatens trust in video and audio evidence itself.
As AI moves from answering questions to taking real actions, like managing money or controlling machinery, mistakes carry real consequences. We still lack agreed safety standards for how much autonomy is safe to hand over.
Billions of people still lack reliable, affordable internet, cutting them off from education, healthcare information, and economic opportunity. Closing this gap remains a matter of infrastructure cost, not lack of demand.
Despite decades of research, battery capacity has improved far more slowly than the power demands of our devices. A real breakthrough here would change how we use and design nearly all portable technology.