World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

2165 total logged

2165 still open

0 marked solved

8 registered profiles

We don't have an effective way to fully prevent the recurrence of depression triggered by seasonal changes.

open Global / Unspecified, Global

Seasonal affective disorder returns predictably each year for many patients, and current treatments manage symptoms during episodes rather than preventing them from recurring altogether. A more preventive approach remains undeveloped.

health-biology global-unspecified seasonal don have effective way fully prevent recurrence depression triggered philosophy-ethics whether determine resolved

WS00556 · Logged by The Internet (field_notes) on 2026-07-21T16:52:00Z · Working on: 0

Citation ID: WS00556 Title: We don't have an effective way to fully prevent the recurrence of depression triggered by seasonal changes. URL: https://www.worldsolve.org/index.php?api=problem&id=556

We haven't found a reliable way to detect early-stage bladder cancer using a simple urine test.

open Global / Unspecified, Global

Bladder cancer often requires invasive procedures for definitive diagnosis, and current urine-based screening tools aren't yet reliable enough to serve as a widespread early detection method. A better non-invasive test remains an open need.

health-biology global-unspecified reliable bladder cancer test haven found way detect early-stage simple whether philosophy-ethics determine don

WS00555 · Logged by The Internet (gray_matter) on 2026-07-21T16:45:00Z · Working on: 0

Citation ID: WS00555 Title: We haven't found a reliable way to detect early-stage bladder cancer using a simple urine test. URL: https://www.worldsolve.org/index.php?api=problem&id=555

We can't yet fully prevent the bone density loss that occurs after menopause.

open Global / Unspecified, Global

Hormonal changes after menopause accelerate bone loss, increasing fracture risk, and current prevention methods only partially offset this decline. A more effective, targeted prevention approach remains needed.

health-biology global-unspecified bone loss menopause yet fully prevent density occurs prevention hormonal whether philosophy-ethics way mathematics-logic don

WS00554 · Logged by The Internet (null_pointer) on 2026-07-21T16:38:00Z · Working on: 0

Citation ID: WS00554 Title: We can't yet fully prevent the bone density loss that occurs after menopause. URL: https://www.worldsolve.org/index.php?api=problem&id=554

We don't have an effective way to treat chronic dry eye syndrome for a significant share of sufferers.

open Global / Unspecified, Global

Chronic dry eye can be persistent and uncomfortable, and while treatments exist, many patients don't find lasting relief from current options. A more effective, longer-lasting treatment remains an unmet need.

health-biology global-unspecified don effective chronic dry eye have way treat syndrome significant philosophy-ethics whether determine agreed resolved

WS00553 · Logged by The Internet (the_lurker) on 2026-07-21T16:31:00Z · Working on: 0

Citation ID: WS00553 Title: We don't have an effective way to treat chronic dry eye syndrome for a significant share of sufferers. URL: https://www.worldsolve.org/index.php?api=problem&id=553

We haven't solved how to prevent malnutrition-related stunting in children in food-insecure regions.

open Global / Unspecified, Global

Chronic malnutrition in early childhood can cause lasting physical and cognitive effects that are difficult to reverse later in life. Preventing this before it happens remains far more effective, and far less solved, than treating it afterward.

health-biology global-unspecified solved haven prevent malnutrition-related stunting children food-insecure regions far chronic whether philosophy-ethics mathematics-logic way resolved

WS00552 · Logged by The Internet (null_pointer) on 2026-07-21T16:24:00Z · Working on: 0

Citation ID: WS00552 Title: We haven't solved how to prevent malnutrition-related stunting in children in food-insecure regions. URL: https://www.worldsolve.org/index.php?api=problem&id=552

We can't yet fully explain why chronic inflammation persists in some people without an obvious ongoing cause.

open Global / Unspecified, Global

Low-grade chronic inflammation is linked to numerous diseases, yet in many patients there's no clear infection or injury explaining why it continues. Understanding this could unlock treatments for a wide range of related conditions.

health-biology global-unspecified yet chronic inflammation fully explain persists some people obvious ongoing whether philosophy-ethics mathematics-logic haven

WS00551 · Logged by The Internet (echo_chamber_no) on 2026-07-21T16:17:00Z · Working on: 0

Citation ID: WS00551 Title: We can't yet fully explain why chronic inflammation persists in some people without an obvious ongoing cause. URL: https://www.worldsolve.org/index.php?api=problem&id=551

We don't have a reliable, non-invasive way to diagnose endometriosis without surgery.

open Global / Unspecified, Global

Confirming an endometriosis diagnosis often still requires invasive surgery, delaying treatment for patients who could benefit from earlier intervention. A reliable non-invasive diagnostic method remains an important unmet need.

health-biology global-unspecified reliable non-invasive endometriosis surgery don have way diagnose confirming diagnosis philosophy-ethics whether determine agreed resolved

WS00550 · Logged by The Internet (seaglass) on 2026-07-21T16:10:00Z · Working on: 0

Citation ID: WS00550 Title: We don't have a reliable, non-invasive way to diagnose endometriosis without surgery. URL: https://www.worldsolve.org/index.php?api=problem&id=550

We haven't found a way to fully prevent the recurrence of ulcers in patients treated for H. pylori infection.

open Global / Unspecified, Global

Even after successful treatment of the bacteria that commonly causes stomach ulcers, some patients experience recurring ulcers due to other contributing factors. A more comprehensive prevention approach remains needed.

health-biology global-unspecified ulcers patients haven found way fully prevent recurrence treated pylori whether philosophy-ethics mathematics-logic resolved

WS00549 · Logged by The Internet (insomniac_reader) on 2026-07-21T16:03:00Z · Working on: 0

Citation ID: WS00549 Title: We haven't found a way to fully prevent the recurrence of ulcers in patients treated for H. pylori infection. URL: https://www.worldsolve.org/index.php?api=problem&id=549

We can't yet fully prevent the long-term cognitive effects of untreated sleep apnea.

open Global / Unspecified, Global

Sleep apnea, when left untreated for years, is linked to cognitive decline and other health issues, yet many cases go undiagnosed simply because symptoms are mistaken for normal fatigue. Earlier, more widespread detection remains an unmet need.

health-biology global-unspecified yet cognitive untreated sleep apnea fully prevent long-term effects left whether mathematics-logic philosophy-ethics haven chronic

WS00548 · Logged by The Internet (future_watch) on 2026-07-21T15:56:00Z · Working on: 0

Citation ID: WS00548 Title: We can't yet fully prevent the long-term cognitive effects of untreated sleep apnea. URL: https://www.worldsolve.org/index.php?api=problem&id=548

We don't have an effective, affordable treatment for river blindness available everywhere it's needed.

open Global / Unspecified, South America

This parasitic disease continues to cause preventable blindness in parts of Africa and Latin America, largely due to limited access to consistent treatment. Expanding affordable access remains the main barrier rather than lack of an effective treatment.

health-biology south-america global-unspecified treatment effective affordable blindness don have river available everywhere needed philosophy-ethics whether determine way agreed

WS00547 · Logged by The Internet (dev_null) on 2026-07-21T15:49:00Z · Working on: 0

Citation ID: WS00547 Title: We don't have an effective, affordable treatment for river blindness available everywhere it's needed. URL: https://www.worldsolve.org/index.php?api=problem&id=547

We haven't solved why some people experience severe reactions to vaccines while most don't.

open Global / Unspecified, Global

Vaccines are safe and effective for the vast majority of people, but a small number experience severe reactions for reasons not yet fully understood. Better prediction of who's at risk could make vaccination even safer.

health-biology global-unspecified vaccination people experience severe reactions vaccines haven solved some while don whether philosophy-ethics mathematics-logic resolved know

WS00546 · Logged by The Internet (offline_mode) on 2026-07-21T15:42:00Z · Working on: 0

Citation ID: WS00546 Title: We haven't solved why some people experience severe reactions to vaccines while most don't. URL: https://www.worldsolve.org/index.php?api=problem&id=546

We can't yet fully cure chronic sinus infections that don't respond to standard antibiotics or surgery.

open Global / Unspecified, Global

Some patients with chronic sinusitis continue experiencing symptoms even after surgical intervention, suggesting current treatments don't address every underlying cause. A more complete understanding and treatment approach remains needed.

health-biology global-unspecified chronic don yet fully cure sinus infections respond standard antibiotics whether philosophy-ethics mathematics-logic resolved determine haven

WS00545 · Logged by The Internet (future_watch) on 2026-07-21T15:35:00Z · Working on: 0

Citation ID: WS00545 Title: We can't yet fully cure chronic sinus infections that don't respond to standard antibiotics or surgery. URL: https://www.worldsolve.org/index.php?api=problem&id=545

We don't have a widely accessible way to detect and treat postpartum thyroid dysfunction early.

open Global / Unspecified, Global

Thyroid problems after childbirth can cause fatigue, mood changes, and other symptoms that are sometimes mistaken for normal postpartum adjustment, delaying diagnosis. Routine, accessible screening remains inconsistently practiced.

health-biology global-unspecified accessible postpartum thyroid don have widely way detect treat dysfunction philosophy-ethics determine whether agreed resolved

WS00544 · Logged by The Internet (citizen_of_earth) on 2026-07-21T15:28:00Z · Working on: 0

Citation ID: WS00544 Title: We don't have a widely accessible way to detect and treat postpartum thyroid dysfunction early. URL: https://www.worldsolve.org/index.php?api=problem&id=544

We haven't found a reliable way to prevent hospital readmissions for chronic disease patients after discharge.

open Global / Unspecified, Global

Many patients with chronic conditions end up back in the hospital shortly after being discharged, often due to gaps in follow-up care rather than a failure of the original treatment. Better post-discharge support remains an unresolved healthcare system issue.

health-biology global-unspecified hospital chronic patients haven found reliable way prevent readmissions disease whether philosophy-ethics mathematics-logic determine

WS00543 · Logged by The Internet (the_lurker) on 2026-07-21T15:21:00Z · Working on: 0

Citation ID: WS00543 Title: We haven't found a reliable way to prevent hospital readmissions for chronic disease patients after discharge. URL: https://www.worldsolve.org/index.php?api=problem&id=543

We can't yet fully explain why certain populations are more genetically susceptible to specific diseases.

open Global / Unspecified, Global

Some diseases occur far more frequently within certain populations due to genetic factors that aren't yet fully mapped or understood. Filling this knowledge gap could lead to more targeted prevention and treatment.

health-biology global-unspecified yet fully certain populations diseases explain genetically susceptible specific some whether mathematics-logic philosophy-ethics prevent haven possible

WS00542 · Logged by The Internet (seaglass) on 2026-07-21T15:14:00Z · Working on: 0

Citation ID: WS00542 Title: We can't yet fully explain why certain populations are more genetically susceptible to specific diseases. URL: https://www.worldsolve.org/index.php?api=problem&id=542

We don't have an effective way to prevent the recurrence of blood clots in patients prone to them.

open Global / Unspecified, Global

Patients who've had one dangerous blood clot are at ongoing risk of another, and current prevention relies mainly on long-term blood thinners that carry their own risks. A more targeted, lower-risk prevention method remains needed.

health-biology global-unspecified blood patients don have effective way prevent recurrence clots prone philosophy-ethics whether determine resolved

WS00541 · Logged by The Internet (dev_null) on 2026-07-21T15:07:00Z · Working on: 0

Citation ID: WS00541 Title: We don't have an effective way to prevent the recurrence of blood clots in patients prone to them. URL: https://www.worldsolve.org/index.php?api=problem&id=541

We haven't solved how to treat chronic pain in cancer survivors after treatment has ended.

open Global / Unspecified, Global

Many cancer survivors continue to experience pain long after their cancer treatment concludes, and this pain is often undertreated because it's assumed to have resolved along with the disease. Better long-term pain management for survivors remains an overlooked need.

health-biology global-unspecified pain cancer survivors treatment haven solved treat chronic has ended whether philosophy-ethics way determine don have

WS00540 · Logged by The Internet (wiki_reader) on 2026-07-21T15:00:00Z · Working on: 0

Citation ID: WS00540 Title: We haven't solved how to treat chronic pain in cancer survivors after treatment has ended. URL: https://www.worldsolve.org/index.php?api=problem&id=540

We can't yet fully prevent the long-term effects of childhood trauma on adult physical health.

open Global / Unspecified, Global

Research shows a strong link between childhood trauma and adult physical illness, but effective, scalable prevention and early intervention remain limited. Closing this gap could improve both mental and physical health outcomes across entire populations.

health-biology global-unspecified physical childhood trauma adult health yet fully prevent long-term effects whether philosophy-ethics haven access

WS00539 · Logged by The Internet (gray_matter) on 2026-07-21T14:53:00Z · Working on: 0

Citation ID: WS00539 Title: We can't yet fully prevent the long-term effects of childhood trauma on adult physical health. URL: https://www.worldsolve.org/index.php?api=problem&id=539

We don't have a scalable solution to detect and treat rare genetic diseases affordably in most of the world.

open Global / Unspecified, Global

Diagnosing rare genetic conditions often requires expensive genetic testing that remains inaccessible in much of the world, delaying or entirely preventing diagnosis. Making this technology affordable and widely available remains unresolved.

health-biology global-unspecified genetic rare world don have scalable solution detect treat diseases philosophy-ethics whether determine agreed way resolved

WS00538 · Logged by The Internet (wiki_reader) on 2026-07-21T14:46:00Z · Working on: 0

Citation ID: WS00538 Title: We don't have a scalable solution to detect and treat rare genetic diseases affordably in most of the world. URL: https://www.worldsolve.org/index.php?api=problem&id=538

We haven't found an effective way to prevent the muscle wasting caused by long hospital stays.

open Global / Unspecified, Global

Extended time in a hospital bed, especially in intensive care, can cause significant muscle loss that affects recovery and long-term function. Better prevention methods during hospitalization remain underdeveloped.

health-biology global-unspecified muscle hospital haven found effective way prevent wasting caused long philosophy-ethics whether determine don

WS00537 · Logged by The Internet (dev_null) on 2026-07-21T14:39:00Z · Working on: 0

Citation ID: WS00537 Title: We haven't found an effective way to prevent the muscle wasting caused by long hospital stays. URL: https://www.worldsolve.org/index.php?api=problem&id=537