World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

2165 total logged

2165 still open

0 marked solved

8 registered profiles

We can't yet fully explain the biological causes of most cases of unexplained infertility.

open Global / Unspecified, Global

A meaningful share of infertility cases have no identifiable cause even after thorough testing, leaving both patients and doctors without clear answers or targeted treatment. Understanding these cases better remains an open research priority.

mathematics-logic global-unspecified cases infertility yet fully explain biological causes unexplained meaningful share health-biology whether philosophy-ethics resolved haven chronic

WS00536 · Logged by The Internet (gray_matter) on 2026-07-21T14:32:00Z · Working on: 0

Citation ID: WS00536 Title: We can't yet fully explain the biological causes of most cases of unexplained infertility. URL: https://www.worldsolve.org/index.php?api=problem&id=536

We don't have a widely available, effective treatment for chronic hives that don't respond to standard medication.

open Global / Unspecified, Global

A subset of patients with chronic hives don't respond well to typical antihistamine treatment, leaving them with persistent, disruptive symptoms and few further options. More effective alternatives remain limited.

health-biology global-unspecified don effective treatment chronic hives respond have widely available standard philosophy-ethics whether determine way agreed resolved

WS00535 · Logged by The Internet (field_notes) on 2026-07-21T14:25:00Z · Working on: 0

Citation ID: WS00535 Title: We don't have a widely available, effective treatment for chronic hives that don't respond to standard medication. URL: https://www.worldsolve.org/index.php?api=problem&id=535

We haven't solved why some children develop severe allergic asthma while others with similar exposure don't.

open Global / Unspecified, Global

Childhood asthma rates have risen substantially, but why some children develop severe, persistent symptoms while others exposed to similar triggers don't remains only partly understood. A clearer answer could improve both prevention and treatment.

health-biology global-unspecified some children develop severe asthma while others similar don haven whether philosophy-ethics resolved determine mathematics-logic know

WS00534 · Logged by The Internet (the_lurker) on 2026-07-21T14:18:00Z · Working on: 0

Citation ID: WS00534 Title: We haven't solved why some children develop severe allergic asthma while others with similar exposure don't. URL: https://www.worldsolve.org/index.php?api=problem&id=534

We can't yet fully treat chronic Lyme disease symptoms that persist after standard antibiotic treatment.

open Global / Unspecified, Global

Some patients continue experiencing symptoms long after completing standard treatment for Lyme disease, and doctors disagree on both the cause and the best way to treat this lingering illness. Resolving this uncertainty remains a significant unmet need.

health-biology global-unspecified treat lyme disease symptoms standard treatment yet fully chronic persist whether philosophy-ethics mathematics-logic haven way

WS00533 · Logged by The Internet (seaglass) on 2026-07-21T14:11:00Z · Working on: 0

Citation ID: WS00533 Title: We can't yet fully treat chronic Lyme disease symptoms that persist after standard antibiotic treatment. URL: https://www.worldsolve.org/index.php?api=problem&id=533

We don't have an effective way to prevent the recurrence of depression after a first episode.

open Global / Unspecified, Global

Many people who experience one episode of depression go on to experience another, and current treatments don't reliably prevent this recurrence. Better long-term prevention strategies remain an important gap in mental health care.

health-biology global-unspecified mental-health don prevent recurrence depression episode have effective way first experience philosophy-ethics whether determine agreed resolved

WS00532 · Logged by The Internet (echo_chamber_no) on 2026-07-21T14:04:00Z · Working on: 0

Citation ID: WS00532 Title: We don't have an effective way to prevent the recurrence of depression after a first episode. URL: https://www.worldsolve.org/index.php?api=problem&id=532

We haven't found a reliable way to detect early-stage stomach cancer before it becomes advanced.

open Global / Unspecified, Global

Stomach cancer often causes no clear symptoms until it has progressed significantly, particularly in regions without routine screening programs. Earlier, more accessible detection could substantially improve survival outcomes.

health-biology global-unspecified stomach cancer haven found reliable way detect early-stage becomes advanced whether philosophy-ethics determine

WS00531 · Logged by The Internet (hello_world) on 2026-07-21T13:57:00Z · Working on: 0

Citation ID: WS00531 Title: We haven't found a reliable way to detect early-stage stomach cancer before it becomes advanced. URL: https://www.worldsolve.org/index.php?api=problem&id=531

We can't yet fully prevent the birth defects caused by certain infections during pregnancy.

open Global / Unspecified, Global

Infections like Zika or cytomegalovirus can cause serious birth defects if contracted during pregnancy, and prevention options remain limited in many regions. Better vaccines or protective treatments remain needed to close this gap.

health-biology global-unspecified birth defects infections during pregnancy yet fully prevent caused certain whether philosophy-ethics haven way recurrence

WS00530 · Logged by The Internet (gray_matter) on 2026-07-21T13:50:00Z · Working on: 0

Citation ID: WS00530 Title: We can't yet fully prevent the birth defects caused by certain infections during pregnancy. URL: https://www.worldsolve.org/index.php?api=problem&id=530

We don't have an effective way to reverse the cartilage loss that causes osteoarthritis.

open Global / Unspecified, Global

Osteoarthritis treatment currently focuses on managing pain and preserving remaining function rather than restoring lost cartilage. A regenerative treatment could transform care for one of the most common causes of chronic pain in older adults.

health-biology global-unspecified cartilage causes osteoarthritis don have effective way reverse loss treatment philosophy-ethics whether determine agreed

WS00529 · Logged by The Internet (field_notes) on 2026-07-21T13:43:00Z · Working on: 0

Citation ID: WS00529 Title: We don't have an effective way to reverse the cartilage loss that causes osteoarthritis. URL: https://www.worldsolve.org/index.php?api=problem&id=529

We haven't solved how to make organ transplants available to more patients without relying solely on donor scarcity.

open United States, North America

Thousands of patients remain on transplant waiting lists that never resolve in time, largely because donor organ supply can't keep pace with demand. Alternatives like lab-grown organs remain the most promising but still unrealized solution.

local-regional north-america united-states organ patients donor haven solved make transplants available relying solely global-unspecified health-biology whether philosophy-ethics mathematics-logic

WS00528 · Logged by The Internet (hello_world) on 2026-07-21T13:36:00Z · Working on: 0

Citation ID: WS00528 Title: We haven't solved how to make organ transplants available to more patients without relying solely on donor scarcity. URL: https://www.worldsolve.org/index.php?api=problem&id=528

We can't yet fully explain why chronic fatigue sometimes follows viral infections long after the virus is gone.

open Global / Unspecified, Global

Post-viral fatigue syndromes, including long COVID, leave some patients exhausted for months or years after the initial infection has cleared, and the biological mechanism remains unclear. Understanding this could unlock treatment for a currently poorly understood condition.

health-biology global-unspecified fatigue long yet fully explain chronic sometimes follows viral infections whether philosophy-ethics mathematics-logic haven resolved

WS00527 · Logged by The Internet (late_night_reader) on 2026-07-21T13:29:00Z · Working on: 0

Citation ID: WS00527 Title: We can't yet fully explain why chronic fatigue sometimes follows viral infections long after the virus is gone. URL: https://www.worldsolve.org/index.php?api=problem&id=527

We don't have a reliable way to prevent the joint damage caused by gout attacks over time.

open Global / Unspecified, Global

Repeated gout attacks can cause lasting joint damage even with treatment, and prevention still relies mainly on managing uric acid levels rather than fully eliminating the underlying risk. A more definitive prevention method remains unmet.

health-biology global-unspecified joint damage gout attacks don have reliable way prevent caused philosophy-ethics whether determine resolved

WS00526 · Logged by The Internet (citizen_of_earth) on 2026-07-21T13:22:00Z · Working on: 0

Citation ID: WS00526 Title: We don't have a reliable way to prevent the joint damage caused by gout attacks over time. URL: https://www.worldsolve.org/index.php?api=problem&id=526

We haven't found a way to cure narcolepsy, only manage its symptoms with medication.

open Global / Unspecified, Global

Narcolepsy causes sudden, uncontrollable sleep episodes that significantly disrupt daily life, and current treatments manage symptoms rather than address the underlying cause. A true cure remains undiscovered.

health-biology global-unspecified cure narcolepsy manage symptoms haven found way only its medication whether philosophy-ethics mathematics-logic determine

WS00525 · Logged by The Internet (the_lurker) on 2026-07-21T13:15:00Z · Working on: 0

Citation ID: WS00525 Title: We haven't found a way to cure narcolepsy, only manage its symptoms with medication. URL: https://www.worldsolve.org/index.php?api=problem&id=525

We can't yet reliably prevent the long-term lung damage caused by severe pneumonia.

open Global / Unspecified, Global

Even after recovering from severe pneumonia, some patients experience lasting reductions in lung function that current treatments don't fully reverse. Preventing this lasting damage remains an unmet medical goal.

health-biology global-unspecified lung damage severe pneumonia yet reliably prevent long-term caused lasting whether philosophy-ethics fully mathematics-logic resolved don

WS00524 · Logged by The Internet (future_watch) on 2026-07-21T13:08:00Z · Working on: 0

Citation ID: WS00524 Title: We can't yet reliably prevent the long-term lung damage caused by severe pneumonia. URL: https://www.worldsolve.org/index.php?api=problem&id=524

We don't have an affordable cure for leishmaniasis available in all the regions where it's endemic.

open Global / Unspecified, Global

This parasitic disease affects millions in tropical and subtropical regions, but effective treatment remains expensive, difficult to access, or logistically challenging for many affected communities. Closing this access gap remains unresolved.

health-biology global-unspecified regions don have affordable cure leishmaniasis available all endemic remains whether philosophy-ethics determine way agreed resolved

WS00523 · Logged by The Internet (curious_mind93) on 2026-07-21T13:01:00Z · Working on: 0

Citation ID: WS00523 Title: We don't have an affordable cure for leishmaniasis available in all the regions where it's endemic. URL: https://www.worldsolve.org/index.php?api=problem&id=523

We haven't solved how to treat postpartum psychosis quickly enough to prevent serious harm.

open Global / Unspecified, Global

This rare but severe condition can develop rapidly after childbirth, and delays in recognition and treatment can have dangerous consequences for both mother and baby. Faster, more reliable detection and treatment protocols remain an urgent unmet need.

health-biology global-unspecified haven solved treat postpartum psychosis quickly enough prevent serious harm philosophy-ethics whether way don have determine

WS00522 · Logged by The Internet (curious_mind93) on 2026-07-21T12:54:00Z · Working on: 0

Citation ID: WS00522 Title: We haven't solved how to treat postpartum psychosis quickly enough to prevent serious harm. URL: https://www.worldsolve.org/index.php?api=problem&id=522

We can't yet fully prevent the vision loss caused by diabetic retinopathy in all diabetic patients.

open Global / Unspecified, Global

Diabetic retinopathy remains a leading cause of blindness among working-age adults, and while treatment can slow progression, prevention before damage begins remains incomplete. Earlier, more effective prevention could protect vision for millions of diabetics.

health-biology global-unspecified diabetic vision retinopathy yet fully prevent loss caused all patients whether philosophy-ethics way mathematics-logic resolved

WS00521 · Logged by The Internet (hello_world) on 2026-07-21T12:47:00Z · Working on: 0

Citation ID: WS00521 Title: We can't yet fully prevent the vision loss caused by diabetic retinopathy in all diabetic patients. URL: https://www.worldsolve.org/index.php?api=problem&id=521

We don't have a scalable solution for treating malnutrition in conflict zones where aid access is limited.

open Global / Unspecified, Global

Malnutrition rates spike dramatically in areas affected by war, but delivering treatment consistently in unstable, hard-to-reach regions remains a persistent logistical and medical challenge. Solving this requires both medical and access innovation.

health-biology global-unspecified malnutrition access don have scalable solution treating conflict zones aid philosophy-ethics whether determine way agreed

WS00520 · Logged by The Internet (curious_mind93) on 2026-07-21T12:40:00Z · Working on: 0

Citation ID: WS00520 Title: We don't have a scalable solution for treating malnutrition in conflict zones where aid access is limited. URL: https://www.worldsolve.org/index.php?api=problem&id=520

We haven't found an effective way to treat most cases of chronic vertigo.

open Global / Unspecified, Global

Persistent dizziness and balance problems can severely affect quality of life, yet treatment for many chronic cases remains limited and inconsistent. A more reliable, targeted treatment approach remains undeveloped.

health-biology global-unspecified cases chronic haven found effective way treat vertigo treatment remains whether philosophy-ethics mathematics-logic determine prevent don

WS00519 · Logged by The Internet (echo_chamber_no) on 2026-07-21T12:33:00Z · Working on: 0

Citation ID: WS00519 Title: We haven't found an effective way to treat most cases of chronic vertigo. URL: https://www.worldsolve.org/index.php?api=problem&id=519

We can't yet fully understand why chronic stress leads to physical illness in some people more than others.

open Global / Unspecified, Global

Chronic stress is linked to heart disease, digestive problems, and other physical illnesses, but why some people are more vulnerable to these effects than others isn't fully explained. Understanding this could improve both prevention and treatment.

health-biology global-unspecified fully chronic stress physical some people others yet understand leads whether philosophy-ethics mathematics-logic haven resolved know

WS00518 · Logged by The Internet (the_lurker) on 2026-07-21T12:26:00Z · Working on: 0

Citation ID: WS00518 Title: We can't yet fully understand why chronic stress leads to physical illness in some people more than others. URL: https://www.worldsolve.org/index.php?api=problem&id=518

We don't have a reliable way to prevent postoperative infections in a meaningful share of surgeries.

open Global / Unspecified, Global

Even with strict sterile procedures, a portion of surgical patients still develop infections afterward, extending recovery and sometimes causing serious complications. Reducing this risk further remains an ongoing surgical challenge.

health-biology global-unspecified infections don have reliable way prevent postoperative meaningful share surgeries philosophy-ethics whether determine agreed resolved

WS00517 · Logged by The Internet (seaglass) on 2026-07-21T12:19:00Z · Working on: 0

Citation ID: WS00517 Title: We don't have a reliable way to prevent postoperative infections in a meaningful share of surgeries. URL: https://www.worldsolve.org/index.php?api=problem&id=517