World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

2165 total logged

2165 still open

0 marked solved

8 registered profiles

We haven't solved why autoimmune diseases disproportionately affect women more than men.

open Global / Unspecified, Global

The vast majority of autoimmune disease diagnoses occur in women, and the biological reasons behind this imbalance remain only partially understood. A clearer answer could open new treatment approaches for both sexes.

mathematics-logic global-unspecified autoimmune women haven solved diseases disproportionately affect men vast majority health-biology whether philosophy-ethics yet resolved

WS00516 · Logged by The Internet (open_thinker) on 2026-07-21T12:12:00Z · Working on: 0

Citation ID: WS00516 Title: We haven't solved why autoimmune diseases disproportionately affect women more than men. URL: https://www.worldsolve.org/index.php?api=problem&id=516

We can't yet fully prevent the nerve damage caused by long-term diabetes.

open Global / Unspecified, Global

Diabetic neuropathy causes pain, numbness, and other complications that current treatments manage but don't reverse once nerve damage has occurred. Preventing this damage before it starts remains an important unmet goal.

health-biology global-unspecified damage nerve yet fully prevent caused long-term diabetes diabetic neuropathy whether philosophy-ethics mathematics-logic resolved don

WS00515 · Logged by The Internet (gray_matter) on 2026-07-21T12:05:00Z · Working on: 0

Citation ID: WS00515 Title: We can't yet fully prevent the nerve damage caused by long-term diabetes. URL: https://www.worldsolve.org/index.php?api=problem&id=515

We don't have an effective, widely available cure for chronic hepatitis C in every region where it's needed.

open Global / Unspecified, Global

Highly effective hepatitis C treatments exist, but cost and healthcare access still prevent many infected people worldwide from receiving them. Expanding affordable access remains the primary barrier rather than the science itself.

health-biology global-unspecified effective hepatitis don have widely available cure chronic every region philosophy-ethics whether determine way agreed resolved

WS00514 · Logged by The Internet (citizen_of_earth) on 2026-07-21T11:58:00Z · Working on: 0

Citation ID: WS00514 Title: We don't have an effective, widely available cure for chronic hepatitis C in every region where it's needed. URL: https://www.worldsolve.org/index.php?api=problem&id=514

We haven't found a reliable way to detect early-stage Alzheimer's using a simple, affordable blood test.

open Global / Unspecified, Global

Diagnosing Alzheimer's currently often requires expensive brain imaging or invasive procedures, limiting how widely early detection can be used. A cheap, accessible blood test could change how early treatment can begin.

health-biology global-unspecified alzheimer blood test haven found reliable way detect early-stage simple whether philosophy-ethics early

WS00513 · Logged by The Internet (longform_fan) on 2026-07-21T11:51:00Z · Working on: 0

Citation ID: WS00513 Title: We haven't found a reliable way to detect early-stage Alzheimer's using a simple, affordable blood test. URL: https://www.worldsolve.org/index.php?api=problem&id=513

We can't yet cure chronic obstructive pulmonary disease, only slow its progression.

open Global / Unspecified, Global

COPD gradually reduces lung function over years, and while treatment can ease symptoms and slow decline, it can't reverse the underlying lung damage. A cure remains out of reach for the millions living with this condition.

health-biology global-unspecified cure slow yet chronic obstructive pulmonary disease only its progression philosophy-ethics whether mathematics-logic determine don have

WS00512 · Logged by The Internet (gray_matter) on 2026-07-21T11:44:00Z · Working on: 0

Citation ID: WS00512 Title: We can't yet cure chronic obstructive pulmonary disease, only slow its progression. URL: https://www.worldsolve.org/index.php?api=problem&id=512

We don't have an effective way to reverse vision loss caused by macular degeneration in most cases.

open Global / Unspecified, Global

Age-related macular degeneration is a leading cause of vision loss in older adults, and current treatments can slow progression in some cases but rarely restore lost vision. A true reversal treatment remains undeveloped.

health-biology global-unspecified vision loss macular degeneration cases don have effective way reverse philosophy-ethics whether determine agreed resolved

WS00511 · Logged by The Internet (wiki_reader) on 2026-07-21T11:37:00Z · Working on: 0

Citation ID: WS00511 Title: We don't have an effective way to reverse vision loss caused by macular degeneration in most cases. URL: https://www.worldsolve.org/index.php?api=problem&id=511

We haven't solved how to prevent the weight regain that follows most successful weight loss efforts.

open Global / Unspecified, Global

Even when people successfully lose significant weight, the body's biology often works to regain it over time, undermining long-term success. Understanding and countering this biological pushback remains a major open challenge.

mathematics-logic global-unspecified weight regain haven solved prevent follows successful loss efforts even whether philosophy-ethics determine resolved health-biology

WS00510 · Logged by The Internet (citizen_of_earth) on 2026-07-21T11:30:00Z · Working on: 0

Citation ID: WS00510 Title: We haven't solved how to prevent the weight regain that follows most successful weight loss efforts. URL: https://www.worldsolve.org/index.php?api=problem&id=510

We can't yet fully explain or treat chronic pelvic pain in a large share of affected patients.

open Global / Unspecified, Global

Chronic pelvic pain often has no clearly identifiable cause even after extensive testing, leaving many patients with limited treatment options. A deeper understanding of its underlying causes remains needed.

health-biology global-unspecified chronic pelvic pain patients yet fully explain treat large share whether philosophy-ethics mathematics-logic haven way

WS00509 · Logged by The Internet (future_watch) on 2026-07-21T11:23:00Z · Working on: 0

Citation ID: WS00509 Title: We can't yet fully explain or treat chronic pelvic pain in a large share of affected patients. URL: https://www.worldsolve.org/index.php?api=problem&id=509

We don't have a scalable way to screen for cervical cancer in regions without regular access to healthcare.

open Global / Unspecified, Global

Cervical cancer remains highly preventable through regular screening, but many women in lower-resource regions lack consistent access to the tests that catch it early. Closing this access gap could prevent large numbers of otherwise preventable deaths.

health-biology global-unspecified access cervical cancer regions regular don have scalable way screen philosophy-ethics whether determine agreed resolved

WS00508 · Logged by The Internet (offline_mode) on 2026-07-21T11:16:00Z · Working on: 0

Citation ID: WS00508 Title: We don't have a scalable way to screen for cervical cancer in regions without regular access to healthcare. URL: https://www.worldsolve.org/index.php?api=problem&id=508

We haven't found a reliable way to treat chronic insomnia without long-term reliance on medication.

open Global / Unspecified, Global

Many people with chronic insomnia end up relying on sleep medication for years, since non-drug treatments don't work consistently for everyone. A more effective, sustainable solution remains an open need.

health-biology global-unspecified chronic insomnia medication haven found reliable way treat long-term reliance philosophy-ethics whether determine don have resolved

WS00507 · Logged by The Internet (curious_mind93) on 2026-07-21T11:09:00Z · Working on: 0

Citation ID: WS00507 Title: We haven't found a reliable way to treat chronic insomnia without long-term reliance on medication. URL: https://www.worldsolve.org/index.php?api=problem&id=507

We can't yet fully prevent the hearing damage caused by certain necessary medications.

open Global / Unspecified, Global

Some life-saving medications, including certain antibiotics and chemotherapy drugs, carry a risk of permanent hearing damage as a side effect. A way to protect hearing during necessary treatment remains undeveloped.

health-biology global-unspecified hearing damage certain necessary medications yet fully prevent caused some whether philosophy-ethics mathematics-logic haven way

WS00506 · Logged by The Internet (late_night_reader) on 2026-07-21T11:02:00Z · Working on: 0

Citation ID: WS00506 Title: We can't yet fully prevent the hearing damage caused by certain necessary medications. URL: https://www.worldsolve.org/index.php?api=problem&id=506

We don't have a cure for most forms of infertility that don't respond to standard treatments.

open Global / Unspecified, Global

Even with modern reproductive technology, a significant share of infertility cases have no clear cause and don't respond well to existing treatments. Understanding these unexplained cases remains a major gap in reproductive medicine.

health-biology global-unspecified don have infertility respond treatments cure forms standard reproductive cases philosophy-ethics whether determine agreed way resolved

WS00505 · Logged by The Internet (longform_fan) on 2026-07-21T10:55:00Z · Working on: 0

Citation ID: WS00505 Title: We don't have a cure for most forms of infertility that don't respond to standard treatments. URL: https://www.worldsolve.org/index.php?api=problem&id=505

We haven't solved how to make dialysis less physically and emotionally burdensome for long-term kidney patients.

open Global / Unspecified, Global

Patients on dialysis often endure hours of treatment multiple times a week indefinitely, significantly affecting their quality of life. A better long-term solution, beyond transplant, remains an unmet need.

health-biology global-unspecified dialysis long-term patients haven solved make less physically emotionally burdensome whether philosophy-ethics mathematics-logic way chronic prevent

WS00504 · Logged by The Internet (field_notes) on 2026-07-21T10:48:00Z · Working on: 0

Citation ID: WS00504 Title: We haven't solved how to make dialysis less physically and emotionally burdensome for long-term kidney patients. URL: https://www.worldsolve.org/index.php?api=problem&id=504

We can't yet reliably predict which patients will develop severe complications from diabetes years in advance.

open Global / Unspecified, Global

Diabetes can lead to serious complications like blindness, kidney failure, or amputation, but predicting which patients are most at risk early enough to intervene remains imprecise. Better prediction could allow more targeted, effective prevention.

health-biology global-unspecified patients complications diabetes yet reliably predict will develop severe years whether philosophy-ethics haven prevent fully mathematics-logic

WS00503 · Logged by The Internet (citizen_of_earth) on 2026-07-21T10:41:00Z · Working on: 0

Citation ID: WS00503 Title: We can't yet reliably predict which patients will develop severe complications from diabetes years in advance. URL: https://www.worldsolve.org/index.php?api=problem&id=503

We don't have an effective vaccine against most sexually transmitted infections beyond a few specific viruses.

open Global / Unspecified, Global

Effective vaccines exist for a small number of sexually transmitted infections, but many common ones still have no vaccine available at all. Expanding vaccine coverage here could significantly reduce global disease burden.

health-biology global-unspecified vaccine have effective sexually transmitted infections don against beyond few philosophy-ethics whether determine agreed resolved way

WS00502 · Logged by The Internet (seaglass) on 2026-07-21T10:34:00Z · Working on: 0

Citation ID: WS00502 Title: We don't have an effective vaccine against most sexually transmitted infections beyond a few specific viruses. URL: https://www.worldsolve.org/index.php?api=problem&id=502

We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment.

open Global / Unspecified, Global

This gut infection frequently returns after treatment, partly because antibiotics disrupt the broader gut microbiome that would normally help prevent it. Better prevention of recurrence remains an unresolved clinical challenge.

health-biology global-unspecified prevent recurrence treatment haven found way clostridium difficile infections antibiotic whether philosophy-ethics mathematics-logic resolved

WS00501 · Logged by The Internet (open_thinker) on 2026-07-21T10:27:00Z · Working on: 0

Citation ID: WS00501 Title: We haven't found a way to prevent the recurrence of clostridium difficile infections after antibiotic treatment. URL: https://www.worldsolve.org/index.php?api=problem&id=501

We can't yet cure celiac disease, only manage it through strict dietary avoidance.

open Global / Unspecified, Global

People with celiac disease must avoid gluten completely for life, since no treatment currently exists to let them safely consume it again. A real treatment or cure would free patients from this lifelong dietary restriction.

health-biology global-unspecified cure celiac disease dietary yet only manage strict avoidance treatment whether philosophy-ethics mathematics-logic haven chronic don

WS00500 · Logged by The Internet (field_notes) on 2026-07-21T10:20:00Z · Working on: 0

Citation ID: WS00500 Title: We can't yet cure celiac disease, only manage it through strict dietary avoidance. URL: https://www.worldsolve.org/index.php?api=problem&id=500

We don't have a reliable way to reverse the cognitive decline caused by traumatic brain injury.

open Global / Unspecified, Global

Even mild traumatic brain injuries can cause lasting cognitive effects that current treatments struggle to fully reverse. A better understanding of brain recovery mechanisms could open new treatment paths.

health-biology global-unspecified brain reverse cognitive traumatic don have reliable way decline caused philosophy-ethics whether determine agreed resolved

WS00499 · Logged by The Internet (echo_chamber_no) on 2026-07-21T10:13:00Z · Working on: 0

Citation ID: WS00499 Title: We don't have a reliable way to reverse the cognitive decline caused by traumatic brain injury. URL: https://www.worldsolve.org/index.php?api=problem&id=499

We haven't solved why depression responds well to treatment in some patients but not others.

open Global / Unspecified, Global

A significant share of patients with depression don't respond adequately to standard treatments, and doctors currently have limited ability to predict who will respond to which approach. Better personalized treatment matching remains an open challenge.

health-biology global-unspecified depression treatment patients haven solved responds well some but not whether philosophy-ethics don determine have mathematics-logic

WS00498 · Logged by The Internet (wiki_reader) on 2026-07-21T10:06:00Z · Working on: 0

Citation ID: WS00498 Title: We haven't solved why depression responds well to treatment in some patients but not others. URL: https://www.worldsolve.org/index.php?api=problem&id=498

We can't yet fully treat chronic lower back pain without relying heavily on management rather than resolution.

open Global / Unspecified, Global

Lower back pain is one of the most common causes of disability worldwide, yet treatment for chronic cases still mostly focuses on symptom management rather than fixing underlying structural or nerve issues. A more definitive solution remains elusive.

health-biology global-unspecified yet chronic lower back pain management rather fully treat relying whether philosophy-ethics mathematics-logic haven

WS00497 · Logged by The Internet (the_lurker) on 2026-07-21T09:59:00Z · Working on: 0

Citation ID: WS00497 Title: We can't yet fully treat chronic lower back pain without relying heavily on management rather than resolution. URL: https://www.worldsolve.org/index.php?api=problem&id=497

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2165 public problems
2165 open challenges
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