World Solve — A living repository of problems worth solving.

What World Solve is

World Solve is a living, citable index of unsolved problems — written one line at a time by Team Humans Club, a global collective of builders, researchers, and entrepreneurs. We do not solve the problems here. We Democratize Innovation.

For builders Skip the search for a problem worth your time. Browse a vetted, growing list and start where the gap is real.

For entrepreneurs Every entry is a potential venture thesis — named early, explained plainly, ready to validate.

For researchers Cite any entry directly, track global needs by region, or pull the full dataset via the public API.

2165 total logged

2165 still open

0 marked solved

8 registered profiles

We don't have an effective way to prevent the progression of glaucoma before vision loss occurs.

open Global / Unspecified, Global

Glaucoma often causes irreversible vision loss before it's diagnosed, since early stages typically have no noticeable symptoms. Better early detection and prevention methods remain a pressing unmet need in eye care.

health-biology global-unspecified have glaucoma vision loss don effective way prevent progression occurs philosophy-ethics determine whether agreed resolved

WS00496 · Logged by The Internet (late_night_reader) on 2026-07-21T09:52:00Z · Working on: 0

Citation ID: WS00496 Title: We don't have an effective way to prevent the progression of glaucoma before vision loss occurs. URL: https://www.worldsolve.org/index.php?api=problem&id=496

We haven't found a reliable cure for chronic sinusitis that works for the majority of sufferers.

open Global / Unspecified, Global

Chronic sinus inflammation affects a large number of people and current treatments, from medication to surgery, often only partially resolve symptoms long-term. A more definitive treatment remains undeveloped.

health-biology global-unspecified chronic haven found reliable cure sinusitis works majority sufferers sinus whether philosophy-ethics mathematics-logic way determine resolved

WS00495 · Logged by The Internet (curious_mind93) on 2026-07-21T09:45:00Z · Working on: 0

Citation ID: WS00495 Title: We haven't found a reliable cure for chronic sinusitis that works for the majority of sufferers. URL: https://www.worldsolve.org/index.php?api=problem&id=495

We can't yet fully prevent the long-term joint damage caused by rheumatoid arthritis.

open Global / Unspecified, Global

Modern treatments can slow rheumatoid arthritis significantly, but many patients still experience some degree of joint damage over time despite treatment. Stopping this damage completely remains an unmet medical goal.

health-biology global-unspecified damage joint rheumatoid arthritis yet fully prevent long-term caused modern whether philosophy-ethics mathematics-logic resolved haven

WS00494 · Logged by The Internet (curious_mind93) on 2026-07-21T09:38:00Z · Working on: 0

Citation ID: WS00494 Title: We can't yet fully prevent the long-term joint damage caused by rheumatoid arthritis. URL: https://www.worldsolve.org/index.php?api=problem&id=494

We don't have a scalable, affordable treatment for hepatitis B available to everyone infected worldwide.

open Global / Unspecified, Global

Effective treatments for hepatitis B exist, but cost and access remain out of reach for many of the hundreds of millions of people living with the infection globally, particularly in lower-income regions. Closing this access gap remains unresolved.

health-biology global-unspecified hepatitis don have scalable affordable treatment available everyone infected worldwide philosophy-ethics whether determine way agreed resolved

WS00493 · Logged by The Internet (open_thinker) on 2026-07-21T09:31:00Z · Working on: 0

Citation ID: WS00493 Title: We don't have a scalable, affordable treatment for hepatitis B available to everyone infected worldwide. URL: https://www.worldsolve.org/index.php?api=problem&id=493

We haven't solved why some people develop severe complications from common infections that most people recover from easily.

open Global / Unspecified, Global

The same virus or bacteria can cause mild illness in most people while triggering severe, sometimes life-threatening complications in others, and we still don't fully understand why. This gap makes predicting and preventing severe outcomes difficult.

health-biology global-unspecified people severe complications haven solved some develop common infections recover philosophy-ethics whether know resolved determine mathematics-logic

WS00492 · Logged by The Internet (seaglass) on 2026-07-21T09:24:00Z · Working on: 0

Citation ID: WS00492 Title: We haven't solved why some people develop severe complications from common infections that most people recover from easily. URL: https://www.worldsolve.org/index.php?api=problem&id=492

We can't yet cure multiple sclerosis, only slow its progression.

open Global / Unspecified, Global

Current treatments for multiple sclerosis can reduce the frequency and severity of flare-ups but can't stop or reverse the underlying immune attack on the nervous system. A true cure remains an unmet goal after decades of research.

health-biology global-unspecified cure multiple sclerosis yet only slow its progression current treatments whether mathematics-logic philosophy-ethics don haven determine

WS00491 · Logged by The Internet (citizen_of_earth) on 2026-07-21T09:17:00Z · Working on: 0

Citation ID: WS00491 Title: We can't yet cure multiple sclerosis, only slow its progression. URL: https://www.worldsolve.org/index.php?api=problem&id=491

We don't have a reliable way to detect Parkinson's disease before physical symptoms like tremors appear.

open Global / Unspecified, Global

By the time visible symptoms of Parkinson's appear, significant neurological damage has usually already occurred, limiting how much treatment can help. Detecting the disease years earlier could open the door to more effective intervention.

mathematics-logic global-unspecified parkinson disease symptoms appear don have reliable way detect physical philosophy-ethics determine whether health-biology agreed resolved

WS00490 · Logged by The Internet (open_thinker) on 2026-07-21T09:10:00Z · Working on: 0

Citation ID: WS00490 Title: We don't have a reliable way to detect Parkinson's disease before physical symptoms like tremors appear. URL: https://www.worldsolve.org/index.php?api=problem&id=490

We haven't found a way to prevent the muscle loss that comes with aging.

open Global / Unspecified, Global

Age-related muscle loss, known as sarcopenia, contributes to frailty and falls in older adults, and current treatments rely mainly on exercise and diet rather than addressing the underlying biological decline. A more direct medical solution remains undeveloped.

mathematics-logic global-unspecified muscle loss haven found way prevent comes aging age-related known health-biology philosophy-ethics whether determine

WS00489 · Logged by The Internet (dev_null) on 2026-07-21T09:03:00Z · Working on: 0

Citation ID: WS00489 Title: We haven't found a way to prevent the muscle loss that comes with aging. URL: https://www.worldsolve.org/index.php?api=problem&id=489

We can't yet fully treat eczema and other chronic skin conditions without ongoing management.

open Global / Unspecified, Global

Chronic skin conditions often require lifelong management with creams and medications rather than a resolution of the underlying immune or genetic causes. A real cure, rather than continuous symptom control, remains unavailable.

health-biology global-unspecified chronic skin conditions management yet fully treat eczema ongoing whether philosophy-ethics mathematics-logic haven resolved

WS00488 · Logged by The Internet (future_watch) on 2026-07-21T08:56:00Z · Working on: 0

Citation ID: WS00488 Title: We can't yet fully treat eczema and other chronic skin conditions without ongoing management. URL: https://www.worldsolve.org/index.php?api=problem&id=488

We don't have an effective way to prevent hair loss caused by genetic or hormonal factors.

open Global / Unspecified, Global

Existing treatments for hair loss can slow the process for some people but rarely reverse it completely, and the underlying biology of hair follicle loss isn't fully understood. A true prevention or reversal method remains undiscovered.

health-biology global-unspecified hair loss don have effective way prevent caused genetic hormonal philosophy-ethics whether determine resolved agreed

WS00487 · Logged by The Internet (null_pointer) on 2026-07-21T08:49:00Z · Working on: 0

Citation ID: WS00487 Title: We don't have an effective way to prevent hair loss caused by genetic or hormonal factors. URL: https://www.worldsolve.org/index.php?api=problem&id=487

We haven't solved why fertility declines with age in ways current treatments only partially address.

open Global / Unspecified, Global

Fertility treatments like IVF help many people conceive, but success rates still drop significantly with age due to biological factors that current medicine can't fully reverse. Understanding and addressing this decline remains incomplete.

mathematics-logic global-unspecified fertility age current treatments haven solved declines ways only partially whether philosophy-ethics health-biology resolved people know

WS00486 · Logged by The Internet (the_lurker) on 2026-07-21T08:42:00Z · Working on: 0

Citation ID: WS00486 Title: We haven't solved why fertility declines with age in ways current treatments only partially address. URL: https://www.worldsolve.org/index.php?api=problem&id=486

We can't yet cure most inherited genetic disorders, only manage their symptoms.

open Global / Unspecified, Global

Conditions caused by a single faulty gene, from cystic fibrosis to muscular dystrophy, still mostly rely on symptom management rather than correcting the genetic cause itself. Gene therapy shows promise but remains far from a widely available cure.

health-biology global-unspecified cure genetic yet inherited disorders only manage symptoms gene conditions philosophy-ethics whether don have determine mathematics-logic

WS00485 · Logged by The Internet (dev_null) on 2026-07-21T08:35:00Z · Working on: 0

Citation ID: WS00485 Title: We can't yet cure most inherited genetic disorders, only manage their symptoms. URL: https://www.worldsolve.org/index.php?api=problem&id=485

We don't have a reliable way to prevent the progression of chronic kidney disease in its early stages.

open Global / Unspecified, Global

Kidney disease often advances silently for years before symptoms appear, and by the time it's caught, treatment options are limited mainly to slowing further decline. Catching and reversing it earlier remains an open medical challenge.

health-biology global-unspecified kidney disease don have reliable way prevent progression chronic its philosophy-ethics whether determine agreed resolved

WS00484 · Logged by The Internet (paper_trail) on 2026-07-21T08:28:00Z · Working on: 0

Citation ID: WS00484 Title: We don't have a reliable way to prevent the progression of chronic kidney disease in its early stages. URL: https://www.worldsolve.org/index.php?api=problem&id=484

We haven't found a way to stop osteoporosis from silently weakening bones until a fracture occurs.

open Global / Unspecified, Global

Bone density loss often goes unnoticed until a fall causes a serious fracture, by which point significant damage has already occurred. Better early detection and prevention could avoid many of these life-altering injuries.

health-biology global-unspecified until fracture haven found way stop osteoporosis silently weakening bones whether philosophy-ethics prevent detect reliable

WS00483 · Logged by The Internet (hello_world) on 2026-07-21T08:21:00Z · Working on: 0

Citation ID: WS00483 Title: We haven't found a way to stop osteoporosis from silently weakening bones until a fracture occurs. URL: https://www.worldsolve.org/index.php?api=problem&id=483

We can't yet reliably prevent the recurrence of kidney stones in people prone to developing them.

open Global / Unspecified, Global

Kidney stones are painful and prone to recurring, yet prevention methods remain limited mostly to general dietary advice rather than addressing individual underlying causes. More targeted prevention could spare patients repeated painful episodes.

health-biology global-unspecified yet kidney stones prone reliably prevent recurrence people developing painful fully whether philosophy-ethics haven way

WS00482 · Logged by The Internet (anon_1904) on 2026-07-21T08:14:00Z · Working on: 0

Citation ID: WS00482 Title: We can't yet reliably prevent the recurrence of kidney stones in people prone to developing them. URL: https://www.worldsolve.org/index.php?api=problem&id=482

We don't have an affordable, widely available treatment for tuberculosis strains resistant to standard drugs.

open Global / Unspecified, Global

Drug-resistant tuberculosis requires longer, more expensive, and more toxic treatment regimens that many patients in affected regions simply can't access or complete. This keeps a preventable disease deadly in the parts of the world least equipped to fight it.

health-biology global-unspecified tuberculosis treatment don have affordable widely available strains resistant standard whether philosophy-ethics determine way agreed resolved

WS00481 · Logged by The Internet (the_lurker) on 2026-07-21T08:07:00Z · Working on: 0

Citation ID: WS00481 Title: We don't have an affordable, widely available treatment for tuberculosis strains resistant to standard drugs. URL: https://www.worldsolve.org/index.php?api=problem&id=481

We haven't solved how to treat postpartum hemorrhage effectively in low-resource settings.

open Global / Unspecified, Global

Severe bleeding after childbirth remains one of the leading causes of maternal death worldwide, disproportionately in regions lacking access to blood transfusions and advanced medical care. Affordable, effective solutions for these settings remain limited.

health-biology global-unspecified settings haven solved treat postpartum hemorrhage effectively low-resource severe bleeding philosophy-ethics affordable whether access remains way

WS00480 · Logged by The Internet (offline_mode) on 2026-07-21T08:00:00Z · Working on: 0

Citation ID: WS00480 Title: We haven't solved how to treat postpartum hemorrhage effectively in low-resource settings. URL: https://www.worldsolve.org/index.php?api=problem&id=480

We can't yet fully explain why chronic pain sometimes persists long after an injury has physically healed.

open Global / Unspecified, Global

Patients sometimes continue to experience pain months or years after the original injury has healed, suggesting the nervous system itself has changed in ways doctors don't fully understand. Solving this could transform treatment for chronic pain conditions.

health-biology global-unspecified pain has fully chronic sometimes injury healed yet explain persists whether philosophy-ethics mathematics-logic haven resolved

WS00479 · Logged by The Internet (echo_chamber_no) on 2026-07-21T07:53:00Z · Working on: 0

Citation ID: WS00479 Title: We can't yet fully explain why chronic pain sometimes persists long after an injury has physically healed. URL: https://www.worldsolve.org/index.php?api=problem&id=479

We don't have a scalable way to detect early-stage lung cancer in people who've never smoked.

open Global / Unspecified, Global

Lung cancer screening guidelines are generally built around smoking history, but a meaningful share of cases occur in people who never smoked at all and often go undetected until later stages. Better screening approaches for this group remain underdeveloped.

health-biology global-unspecified lung cancer people never smoked don have scalable way detect whether philosophy-ethics determine resolved agreed haven

WS00478 · Logged by The Internet (gray_matter) on 2026-07-21T07:46:00Z · Working on: 0

Citation ID: WS00478 Title: We don't have a scalable way to detect early-stage lung cancer in people who've never smoked. URL: https://www.worldsolve.org/index.php?api=problem&id=478

We haven't found a reliable cure for irritable bowel syndrome affecting a large share of the population.

open Global / Unspecified, Global

IBS causes chronic digestive discomfort for a significant portion of people worldwide, yet treatment options remain limited to symptom management rather than addressing root causes. The underlying biology is still not fully mapped out.

health-biology global-unspecified haven found reliable cure irritable bowel syndrome affecting large share philosophy-ethics whether chronic yet mathematics-logic fully

WS00477 · Logged by The Internet (paper_trail) on 2026-07-21T07:39:00Z · Working on: 0

Citation ID: WS00477 Title: We haven't found a reliable cure for irritable bowel syndrome affecting a large share of the population. URL: https://www.worldsolve.org/index.php?api=problem&id=477

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2165 public problems
2165 open challenges
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