Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.
health-biology
global-unspecified
must
next-generation
vaccine
platforms
ready
respond
weeks
new
threats
variant
infrastructure
will
climate-environment
data
technology-computing
society-governance
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
persistent
systems
society-governance
health
whether
public
data
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
variant
data
society-governance
systems
economics-resources
will
health
open
Global / Unspecified, Global
Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.
climate-environment
global-unspecified
air-pollution
will
pollution
urbanisation
drive
new
patterns
injury
exposure
lifestyle
disease
health
health-biology
air
african
open
Global / Unspecified, Global
Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.
health-biology
global-unspecified
will
metabolic
food-system
transformations
reshape
human
microbiomes
health
ultra-processed
foods
climate-environment
new
society-governance
technology-computing
food
system
open
Global / Unspecified, Global
Resistance genes move through soil, water, and food chains, making hospital-focused interventions insufficient. One-Health regulatory frameworks and monitoring tools are required.
climate-environment
global-unspecified
antibiotic
stewardship
will
need
extend
beyond
hospitals
agriculture
environment
resistance
water
human
society-governance
real
haven
food
open
Global / Unspecified, Global
Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.
climate-environment
global-unspecified
therapies
new
cancer
will
demand
better
real-world
data
understand
long-term
society-governance
public
registries
health-biology
governance
technology-computing
open
Global / Unspecified, Global
Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.
climate-environment
global-unspecified
data
therapies
new
cancer
will
demand
better
real-world
understand
long-term
society-governance
technology-computing
infrastructure
african
systems
europe
open
Global / Unspecified, Global
By 2040, many patients will have multiple chronic conditions with overlapping treatments and risks. Care orchestration tools and polypharmacy-optimisation systems are needed.
society-governance
global-unspecified
will
multi-morbidity
become
norm
older
adults
2040
patients
have
multiple
systems
health-biology
public
philosophy-ethics
whether
mathematics-logic
open
Global / Unspecified, Global
Demand will outpace supply of clinicians unless task-shifting, automation, and new professions emerge. Workforce-planning analytics and training platforms can support transitions.
technology-computing
global-unspecified
will
new
health
workforce
shortages
burnout
grow
models
care
demand
health-biology
social-civic-problems
economics-resources
infrastructure
open
Global / Unspecified, Global
Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.
health-biology
global-unspecified
mental-health
will
climate-linked
displacement
create
new
health-service
needs
migrants
health
displaced
mental
access
society-governance
african
care
open
Global / Unspecified, Global
Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.
health-biology
global-unspecified
mental-health
will
climate-linked
displacement
create
new
health-service
needs
migrants
variant
focuses
health
infrastructure
data
society-governance
climate-environment
open
Global / Unspecified, Global
Pervasive digital platforms may exacerbate sleep, focus, and mood problems. New prevention strategies, digital hygiene tools, and regulatory frameworks will be needed.
technology-computing
global-unspecified
digital
will
mental-health
infrastructure
struggle
keep
pace
rising
addiction
society-governance
african
systems
public
low
institutions
open
Global / Unspecified, Global
Over the next 10–20 years, biosensors will track vital signs, metabolites, and behaviours, but analytics and integration into care will lag. Edge-computing and clinically validated algorithms will be needed.
technology-computing
global-unspecified
will
wearable
implantable
sensors
generate
continuous
health
data
underused
over
health-biology
climate-environment
society-governance
climate
new
economics-resources
open
Global / Unspecified, Global
Advances in synthetic biology may blur the line between accidental and deliberate outbreaks. Genomic anomaly detection and secure reporting pipelines could help.
society-governance
global-unspecified
bio-surveillance
systems
will
need
detect
engineered
threats
well
natural
health-biology
philosophy-ethics
detection
distributed
economics-resources
ensuring
outbreak
open
Global / Unspecified, Global
Poor-quality medicines accelerate resistance and treatment failure. Track-and-trace systems and quality-testing infrastructure are needed.
health-biology
global-unspecified
resistance
antimicrobial
low-resource
settings
will
exacerbated
counterfeit
substandard
drugs
poor-quality
systems
society-governance
climate-environment
infrastructure
technology-computing
economics-resources
open
Global / Unspecified, Global
Access to anti-ageing interventions could be skewed toward wealthy groups without deliberate policy. Equity-oriented regulation and public programmes will be required.
society-governance
global-unspecified
human
longevity
research
may
widen
socio-economic
divides
lifespan
access
anti-ageing
protocols
philosophy-ethics
will
ethical
health-biology
development
open
Global / Unspecified, Global
Lyme disease, dengue, and other infections may reach new regions. Integrated vector-surveillance and control platforms will be crucial.
health-biology
global-unspecified
will
disease
climate-induced
expansion
tick
mosquito
habitats
change
geography
lyme
society-governance
governance
building
cities
new
open
Global / Unspecified, Global
Models may generate candidate molecules rapidly, challenging traditional assessment. Simulation-based validation and adaptive regulatory frameworks will be needed.
society-governance
global-unspecified
will
regulatory
ai-designed
drugs
require
new
science
approaches
models
may
governance
health-biology
climate-environment
technology-computing
health
frameworks
open
Global / Unspecified, Global
Bioprinting and stem-cell therapies may not scale fast enough to meet demand. Organ-allocation optimisation and cross-border sharing platforms remain important.
health-biology
global-unspecified
may
future
organ
shortage
crises
persist
despite
advances
regenerative
medicine
climate-environment
technology-computing
food
whether
philosophy-ethics
microbial
