We don't have a fair system for compensating communities harmed by decades of industrial pollution.
open
Global / Unspecified, Global
Some communities have lived with contaminated air, water, or soil for generations due to nearby industrial activity, with little formal compensation or cleanup. Establishing fair, enforceable accountability remains a persistent governance gap.
society-governance
global-unspecified
have
fair
communities
industrial
don
system
compensating
harmed
decades
pollution
philosophy-ethics
whether
determine
agreed
resolved
way
Citation ID: WS00236
Title: We don't have a fair system for compensating communities harmed by decades of industrial pollution.
URL: https://www.worldsolve.org/index.php?api=problem&id=236
We haven't solved how to prevent childhood malnutrition in regions affected by conflict or drought.
open
Global / Unspecified, Global
Malnutrition during early childhood can cause lifelong developmental harm, and crises like war or drought regularly disrupt food access for vulnerable children. Building more resilient food delivery systems in crisis zones remains urgently unresolved.
health-biology
global-unspecified
childhood
malnutrition
drought
haven
solved
prevent
regions
affected
conflict
food
whether
mathematics-logic
philosophy-ethics
way
Citation ID: WS00235
Title: We haven't solved how to prevent childhood malnutrition in regions affected by conflict or drought.
URL: https://www.worldsolve.org/index.php?api=problem&id=235
We can't yet fully explain the biological causes behind chronic fatigue syndrome.
open
Global / Unspecified, Global
Chronic fatigue syndrome leaves patients severely limited in daily function, yet its underlying biological cause remains poorly understood and often dismissed. Without a clear cause, effective treatment remains extremely difficult to develop.
mathematics-logic
global-unspecified
yet
biological
chronic
fatigue
syndrome
fully
explain
causes
behind
cause
health-biology
whether
philosophy-ethics
haven
determine
Citation ID: WS00234
Title: We can't yet fully explain the biological causes behind chronic fatigue syndrome.
URL: https://www.worldsolve.org/index.php?api=problem&id=234
We don't have a scalable way to detect skin cancer early using simple, affordable tools.
open
Global / Unspecified, Global
Early detection dramatically improves skin cancer survival rates, but many people lack easy access to dermatology screening. A cheap, widely available detection tool could catch far more cases before they become dangerous.
health-biology
global-unspecified
skin
cancer
early
don
have
scalable
way
detect
simple
affordable
philosophy-ethics
whether
determine
agreed
resolved
Citation ID: WS00233
Title: We don't have a scalable way to detect skin cancer early using simple, affordable tools.
URL: https://www.worldsolve.org/index.php?api=problem&id=233
We haven't found a way to prevent the spread of drug-resistant tuberculosis in poorer countries.
open
Global / Unspecified, Global
Tuberculosis remains a major killer in some regions, and drug-resistant strains are becoming harder and more expensive to treat. Slowing this resistance requires both better medicine access and improved treatment adherence support.
health-biology
global-unspecified
tuberculosis
drug-resistant
haven
found
way
prevent
spread
poorer
countries
remains
whether
philosophy-ethics
mathematics-logic
resolved
Citation ID: WS00232
Title: We haven't found a way to prevent the spread of drug-resistant tuberculosis in poorer countries.
URL: https://www.worldsolve.org/index.php?api=problem&id=232
We can't yet cure most forms of infertility affecting both men and women.
open
Global / Unspecified, Global
Infertility affects a significant share of couples trying to conceive, and treatments like IVF don't work for everyone or every cause. A deeper understanding of underlying causes could open new, more effective treatment paths.
health-biology
global-unspecified
infertility
yet
cure
forms
affecting
both
men
women
affects
significant
philosophy-ethics
whether
don
have
determine
way
Citation ID: WS00231
Title: We can't yet cure most forms of infertility affecting both men and women.
URL: https://www.worldsolve.org/index.php?api=problem&id=231
We don't have a reliable way to predict and prevent postpartum depression before it develops.
open
Global / Unspecified, Global
Postpartum depression affects many new parents, often going undiagnosed until it significantly affects their wellbeing and their child's early development. Better early prediction could allow support to begin before symptoms take hold.
health-biology
global-unspecified
postpartum
depression
don
have
reliable
way
predict
prevent
develops
affects
philosophy-ethics
whether
determine
agreed
resolved
Citation ID: WS00230
Title: We don't have a reliable way to predict and prevent postpartum depression before it develops.
URL: https://www.worldsolve.org/index.php?api=problem&id=230
We haven't solved how to make quality eldercare accessible and affordable as populations age worldwide.
open
Global / Unspecified, Global
Many countries are seeing their elderly populations grow faster than their caregiving systems can support, straining families and healthcare systems alike. A scalable, affordable model for elder care remains an unmet need almost everywhere.
health-biology
global-unspecified
affordable
populations
haven
solved
make
quality
eldercare
accessible
age
worldwide
whether
mathematics-logic
philosophy-ethics
systems
resolved
african
Citation ID: WS00229
Title: We haven't solved how to make quality eldercare accessible and affordable as populations age worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=229
We can't yet stop food allergies from becoming more common in children worldwide.
open
Global / Unspecified, Global
Food allergy rates have been rising for decades, and the exact reasons behind this trend remain only partially understood. Understanding the cause could help prevent, not just manage, this growing health issue.
climate-environment
global-unspecified
food
yet
stop
allergies
becoming
common
children
worldwide
allergy
rates
philosophy-ethics
whether
don
resolved
determine
have
Citation ID: WS00228
Title: We can't yet stop food allergies from becoming more common in children worldwide.
URL: https://www.worldsolve.org/index.php?api=problem&id=228
We don't have a cure for most rare genetic diseases affecting small patient populations.
open
United States, North America
Because rare diseases affect few patients, there's often little financial incentive for researchers or companies to develop treatments. Thousands of rare conditions remain effectively untreated as a direct result.
health-biology
north-america
united-states
rare
diseases
don
have
cure
genetic
affecting
small
patient
populations
global-unspecified
whether
philosophy-ethics
resolved
determine
Citation ID: WS00227
Title: We don't have a cure for most rare genetic diseases affecting small patient populations.
URL: https://www.worldsolve.org/index.php?api=problem&id=227
We haven't found a way to make organ donation opt-out, not opt-in, fairly and globally.
open
Global / Unspecified, Global
Countries with opt-out organ donation systems tend to have far higher donation rates, saving more lives, but implementing this fairly and ethically worldwide remains politically and culturally difficult.
philosophy-ethics
global-unspecified
donation
organ
opt-out
fairly
haven
found
way
make
not
opt-in
whether
mathematics-logic
determine
resolved
Citation ID: WS00226
Title: We haven't found a way to make organ donation opt-out, not opt-in, fairly and globally.
URL: https://www.worldsolve.org/index.php?api=problem&id=226
We can't yet explain why identical treatments work well for some patients and not others with the same disease.
open
Global / Unspecified, Global
Personalized medicine is improving, but doctors still can't always predict in advance which patients will respond to a given treatment. Solving this could avoid painful trial-and-error treatment periods for patients.
health-biology
global-unspecified
patients
yet
explain
identical
treatments
work
well
some
not
others
whether
philosophy-ethics
haven
fully
mathematics-logic
chronic
Citation ID: WS00225
Title: We can't yet explain why identical treatments work well for some patients and not others with the same disease.
URL: https://www.worldsolve.org/index.php?api=problem&id=225
We don't have a widely available treatment that slows the progression of most forms of dementia.
open
Global / Unspecified, Global
Existing dementia treatments offer only modest, temporary relief from symptoms rather than meaningfully slowing the underlying disease. A real disease-modifying treatment remains one of medicine's most sought-after breakthroughs.
health-biology
global-unspecified
treatment
dementia
don
have
widely
available
slows
progression
forms
existing
whether
philosophy-ethics
determine
way
agreed
resolved
Citation ID: WS00224
Title: We don't have a widely available treatment that slows the progression of most forms of dementia.
URL: https://www.worldsolve.org/index.php?api=problem&id=224
We haven't solved how to detect sepsis early enough to prevent it from becoming fatal.
open
Global / Unspecified, Global
Sepsis can escalate from a treatable infection to a life-threatening emergency within hours, and current diagnosis often catches it too late. Faster detection tools could dramatically reduce sepsis deaths in hospitals.
health-biology
global-unspecified
sepsis
haven
solved
detect
early
enough
prevent
becoming
fatal
escalate
philosophy-ethics
whether
way
Citation ID: WS00223
Title: We haven't solved how to detect sepsis early enough to prevent it from becoming fatal.
URL: https://www.worldsolve.org/index.php?api=problem&id=223
We can't yet reverse hearing loss caused by aging or long-term noise exposure.
open
Global / Unspecified, Global
Once the tiny hair cells in the inner ear are damaged, human bodies can't naturally regrow them, making most hearing loss permanent. Cell regeneration therapies show early promise but remain far from mainstream treatment.
health-biology
global-unspecified
hearing
loss
yet
reverse
caused
aging
long-term
noise
exposure
once
philosophy-ethics
whether
prevent
way
don
have
Citation ID: WS00222
Title: We can't yet reverse hearing loss caused by aging or long-term noise exposure.
URL: https://www.worldsolve.org/index.php?api=problem&id=222
We don't have affordable genetic testing available to everyone who could benefit from it.
open
Global / Unspecified, Global
Genetic testing can reveal risk for serious inherited conditions, but cost and access limit it mostly to wealthier patients and countries. Broader affordability could catch preventable conditions far earlier for many more people.
health-biology
global-unspecified
genetic
testing
don
have
affordable
available
everyone
benefit
conditions
reveal
philosophy-ethics
whether
determine
resolved
agreed
way
Citation ID: WS00221
Title: We don't have affordable genetic testing available to everyone who could benefit from it.
URL: https://www.worldsolve.org/index.php?api=problem&id=221
We haven't found a way to stop the immune system from attacking healthy joints in arthritis.
open
Global / Unspecified, Global
Autoimmune arthritis causes the body's own immune system to damage joint tissue, leading to chronic pain and disability. Current treatments manage inflammation but don't address why the immune system attacks in the first place.
mathematics-logic
global-unspecified
immune
system
arthritis
haven
found
way
stop
attacking
healthy
joints
whether
philosophy-ethics
health-biology
resolved
don
fully
Citation ID: WS00220
Title: We haven't found a way to stop the immune system from attacking healthy joints in arthritis.
URL: https://www.worldsolve.org/index.php?api=problem&id=220
We can't yet grow blood in a lab reliably enough to end donor blood shortages.
open
Global / Unspecified, Global
Blood donation shortages remain a recurring problem worldwide, especially during emergencies when demand spikes suddenly. Lab-grown blood could remove dependence on donor supply entirely, but the technology isn't yet practical at scale.
health-biology
global-unspecified
blood
yet
donor
shortages
grow
lab
reliably
enough
end
donation
affordable
build
philosophy-ethics
haven
whether
determine
Citation ID: WS00219
Title: We can't yet grow blood in a lab reliably enough to end donor blood shortages.
URL: https://www.worldsolve.org/index.php?api=problem&id=219
We don't have a reliable cure for tinnitus, the constant ringing some people hear in their ears.
open
Global / Unspecified, Global
Tinnitus affects a significant portion of the population and can seriously impact quality of life, yet current treatments only manage symptoms rather than eliminate the underlying cause.
health-biology
global-unspecified
tinnitus
don
have
reliable
cure
constant
ringing
some
people
hear
philosophy-ethics
whether
determine
resolved
agreed
way
Citation ID: WS00218
Title: We don't have a reliable cure for tinnitus, the constant ringing some people hear in their ears.
URL: https://www.worldsolve.org/index.php?api=problem&id=218
We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else.
open
Global / Unspecified, Global
A small number of people show natural resistance to certain infections or conditions, and understanding why could reveal entirely new treatment approaches. This resistance remains only partially understood at a genetic level.
health-biology
global-unspecified
people
haven
solved
some
naturally
resistant
diseases
affect
nearly
everyone
whether
philosophy-ethics
mathematics-logic
resolved
know
determine
Citation ID: WS00217
Title: We haven't solved why some people are naturally resistant to diseases that affect nearly everyone else.
URL: https://www.worldsolve.org/index.php?api=problem&id=217