Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
A few seconds of someone's voice is now enough to generate convincing fake audio of them saying anything, and current detection tools often fail to catch high-quality fakes in real time. This is already being used for financial scams targeting families and businesses.
economics-resources
global-unspecified
voice
being
stop
deepfake
cloning
convincingly
fraud
impersonation
few
seconds
whether
philosophy-ethics
way
prevent
resolved
fake
open
Global / Unspecified, Global
Over the next two decades, rising resistance in bacteria, fungi, and parasites risks undermining surgery, chemotherapy, and intensive care. Global surveillance networks, rapid diagnostics, and new antimicrobial development platforms are crucial to avert a post-antibiotic era.
health-biology
global-unspecified
antimicrobial
resistance
over
next
decades
make
routine
infections
deadly
again
will
data
climate-environment
society-governance
infrastructure
europe
open
Global / Unspecified, Global
Deforestation, wildlife trade, and dense urbanisation increase contact between humans and animal reservoirs, enabling novel pathogens to emerge. Planetary-health surveillance systems and adaptable vaccine platforms will be essential.
health-biology
global-unspecified
deforestation
future
pandemics
driven
zoonotic
spillover
likely
become
frequent
wildlife
systems
society-governance
surveillance
detecting
rapid
without
open
Global / Unspecified, Global
Deforestation, wildlife trade, and dense urbanisation increase contact between humans and animal reservoirs, enabling novel pathogens to emerge. Planetary-health surveillance systems and adaptable vaccine platforms will be essential.
health-biology
global-unspecified
deforestation
future
pandemics
driven
zoonotic
spillover
likely
become
frequent
variant
focuses
society-governance
systems
data
technology-computing
infrastructure
open
Global / Unspecified, Global
Ageing populations, urban diets, and pollution will drive surges in cardiovascular disease, diabetes, cancer, and chronic respiratory conditions. Scalable chronic-care models, digital coaching tools, and preventive policy reforms are needed.
society-governance
global-unspecified
policy-reform
will
non-communicable
diseases
dominate
mortality
low-income
countries
2040
ageing
populations
health-biology
health
climate-environment
non
communicable
open
Global / Unspecified, Global
By the 2030s and 2040s, extreme heat and shifting mosquito ranges will expand malaria, dengue, and other infections into new regions. Heat-health early-warning systems and climate-sensitive disease-modelling platforms must be deployed.
health-biology
global-unspecified
climate-change
will
climate
change
amplify
heat-related
illness
vector-borne
diseases
2030s
2040s
climate-environment
society-governance
systems
governance
building
open
Global / Unspecified, Global
Rising stress, social isolation, and economic precarity will increase depression, anxiety, and cognitive disorders, especially among youth. Scalable digital therapeutics and integrated community mental-health ecosystems are needed.
economics-resources
global-unspecified
mental-health
health
disorders
will
among
mental
neurodevelopmental
largest
burdens
rising
health-biology
society-governance
remains
african
access
haven
open
Global / Unspecified, Global
Rising stress, social isolation, and economic precarity will increase depression, anxiety, and cognitive disorders, especially among youth. Scalable digital therapeutics and integrated community mental-health ecosystems are needed.
economics-resources
global-unspecified
mental-health
health
disorders
will
among
mental
neurodevelopmental
largest
burdens
variant
health-biology
society-governance
data
african
technology-computing
climate-environment
open
Global / Unspecified, Global
The share of people over 65 will rise sharply, raising demand for geriatric care, dementia services, and palliative care. Robotics-assisted caregiving, home-based monitoring, and new care-financing models could ease the burden.
economics-resources
global-unspecified
care
will
ageing
populations
strain
health
systems
long-term
infrastructure
share
society-governance
health-biology
public
open
Global / Unspecified, Global
Genomic and biomarker-driven therapies will transform oncology and rare disease care, but high costs and limited capacity risk concentrating benefits in wealthy populations. Fair pricing, global data-sharing, and low-cost diagnostics will be critical.
health-biology
global-unspecified
will
limited
precision
medicine
create
new
inequalities
access
remains
genomic
society-governance
economics-resources
whether
institutions
philosophy-ethics
open
Global / Unspecified, Global
By 2040, editing tools and gene drives could reshape ecosystems or be misused to create dangerous pathogens. Governance frameworks, secure design pipelines, and ethics review infrastructures are needed.
philosophy-ethics
global-unspecified
editing
synthetic
biology
genome
will
raise
complex
biosecurity
ethical
2040
society-governance
governance
mathematics-logic
frameworks
use
open
Global / Unspecified, Global
AI tools will increasingly support diagnosis and triage, but biases and opaque models may harm patients. Transparent validation frameworks, audit trails, and clinician–AI training curricula will be key.
society-governance
global-unspecified
will
human
collaboration
clinical
decision-making
need
rigorous
oversight
tools
increasingly
climate-environment
health-biology
systems
climate
technology-computing
without
open
Global / Unspecified, Global
AI tools will increasingly support diagnosis and triage, but biases and opaque models may harm patients. Transparent validation frameworks, audit trails, and clinician–AI training curricula will be key.
climate-environment
global-unspecified
will
human
collaboration
clinical
decision-making
need
rigorous
oversight
variant
focuses
society-governance
infrastructure
data
technology-computing
health-biology
climate
open
Global / Unspecified, Global
Electronic health record silos, uneven standards, and privacy concerns will hinder cross-institutional analytics. Federated learning, privacy-preserving linkage, and open standards could unlock insights.
society-governance
global-unspecified
will
learning
health
data
interoperability
remain
bottleneck
systems
standards
electronic
open
public
technical
technology-computing
health-biology
climate-environment
open
Global / Unspecified, Global
mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.
health-biology
global-unspecified
must
next-generation
vaccine
platforms
ready
respond
weeks
new
threats
manufacturing
technology-computing
economics-resources
will
pathogens
market
rapid
open
Global / Unspecified, Global
mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.
health-biology
global-unspecified
must
next-generation
vaccine
platforms
ready
respond
weeks
new
threats
variant
infrastructure
will
climate-environment
data
technology-computing
society-governance
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
persistent
systems
society-governance
health
whether
public
data
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
variant
data
society-governance
systems
economics-resources
will
health
open
Global / Unspecified, Global
Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.
climate-environment
global-unspecified
air-pollution
will
pollution
urbanisation
drive
new
patterns
injury
exposure
lifestyle
disease
health
health-biology
air
african
open
Global / Unspecified, Global
Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.
health-biology
global-unspecified
will
metabolic
food-system
transformations
reshape
human
microbiomes
health
ultra-processed
foods
climate-environment
new
society-governance
technology-computing
food
system
