World Solve

Develop surveillance and affordable safety protocols for dialysis delivered in fragmented private and informal systems, where contamination and equipment reuse may go undocumented.

Despite recognition of its importance, reliable methods for integrated wildlife-livestock-human zoonotic spillover surveillance are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for education and training systems that prepare populations for climate-driven livelihood transitions. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Small-scale fishers in Bangladesh often operate without formal recognition or access to credit, insurance, or market infrastructure, leaving them economically vulnerable and undercounted in fisheries policy.

Postpartum hemorrhage remains a leading cause of maternal death in Indonesia because low-resource facilities often lack rapid blood-typing, stored blood products, and trained staff to intervene within the critical first hour after delivery.

Achieving nature-based solutions for coastal and riverine flood risk that support livelihoods and biodiversity at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Rural clinics in Kenya lose a significant share of temperature-sensitive vaccines to cold-chain breaks between district depots and final delivery points, driven by unreliable electricity, sparse refrigerated transport, and thin logistics staffing.

Last-mile freight delivery in Egypt's congested cities remains dominated by diesel vehicles, and electric alternatives face high upfront costs and inadequate charging infrastructure.

Despite recognition of its importance, reliable methods for ambient methane oxidation catalysts for livestock regions are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Current approaches to education and workforce systems preparing people for livelihoods in a net-zero economy either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for technologies enabling precise and equitable delivery of agricultural inputs at smallholder scale. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Achieving nature-based solutions for coastal protection that support fisheries and tourism livelihoods at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

A persistent gap exists in realizing practical, scalable solutions for low-bandwidth digital tools that deliver high-quality education in connectivity-poor areas. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

The absence of robust, context-adapted solutions for systems ensuring the safety and reliability of autonomous systems in healthcare delivery creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.