AI-designed drugs will require new regulatory science approaches.
Models may generate candidate molecules rapidly, challenging traditional assessment. Simulation-based validation and adaptive regulatory frameworks will be needed.
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
Models may generate candidate molecules rapidly, challenging traditional assessment. Simulation-based validation and adaptive regulatory frameworks will be needed.
Ultra-high-energy cosmic rays’ origins remain unclear, challenging acceleration models. Distributed detector arrays and multi-messenger astronomy could identify sources.
Turbulence controls transport and heating but remains mathematically challenging. Laboratory plasma experiments and numerical advances are needed.
Formation flying for interferometry demands extreme precision. Advances in control theory and sensor technology are needed.
This parasitic disease affects millions in tropical and subtropical regions, but effective treatment remains expensive, difficult to access, or logistically challenging for many affected communities. Closing this access gap remains unresolved.
Physical hardware used in sensitive systems can sometimes be tampered with before installation, and detecting this tampering reliably and affordably remains technically challenging. Closing this hardware security gap remains an unresolved priority.