World Solve

Overfishing has collapsed several near-shore fish stocks critical to coastal livelihoods in Chile, and existing quota systems are poorly enforced due to limited monitoring of small-scale fishing fleets.

Farmers near protected reserves in Morocco suffer repeated crop and livestock losses to wildlife, and existing deterrents are either ineffective or too costly for widespread deployment, fueling retaliatory killings.

Despite recognition of its importance, reliable methods for methods for reducing the transmission of antimicrobial resistance through food and environmental pathways are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Current approaches to methods for assessing the cumulative impacts of climate change and other stressors on human health either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Achieving affordable and scalable solutions for safe sanitation in dense urban informal settlements at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Long-term anxiety and depression tied to job insecurity and informal labor in Chile are poorly quantified, making it difficult for policymakers to justify investment in preventive mental health infrastructure.

Despite recognition of its importance, reliable methods for solutions for providing high-quality primary healthcare in remote and underserved regions are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Girls in parts of Chile disproportionately drop out of secondary school due to a combination of early marriage pressure, unpaid domestic labor expectations, and lack of safe transportation to school.

Design water-allocation and enforcement systems that reduce consumption among high users without shifting disproportionate burdens onto low-income residents.

Current approaches to methods for assessing the resilience of critical infrastructure to compound climate and cyber risks either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Despite recognition of its importance, reliable methods for pathways for achieving high rates of energy efficiency and demand reduction in buildings and industry are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for city-scale anthropogenic versus biogenic CO2 attribution networks creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for protocols for the responsible conduct of research involving human enhancement technologies. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for biotechnologies enabling the rapid development of vaccines against unknown future pathogens are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for complete proteins from agricultural lignocellulosic residues creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.