Automation may reduce routine collaboration and informal learning, especially for remote and platform workers. Future work design must preserve mentorship, belonging, collective problem-solving, and psychological health. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
europe
germany
preventing
social
isolation
highly
automated
workplaces
under
geopolitical
fragmentation
design
economics-resources
climate-environment
society-governance
systems
quantum
Climate change and urban pumping changes may cause groundwater to enter basements, transit systems, utilities, and foundations. Cities need mapping, waterproofing, drainage, and financing strategies that address slow cumulative damage. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
climate-change
groundwater
adapting
underground
infrastructure
rising
under
geopolitical
fragmentation
climate
change
technology-computing
climate-environment
society-governance
systems
Decision-makers lack integrated, high-resolution models of ocean chemistry, biology, currents, and human activity. The open problem is building trustworthy systems that support decisions without creating false confidence from incomplete data. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
europe
norway
real-time
marine
ecosystem
digital
twins
under
geopolitical
fragmentation
data
decision-makers
economics-resources
society-governance
systems
climate-environment
infrastructure
Growing desalination could produce concentrated brine and chemical waste at scales that threaten coastal ecosystems. The challenge is improving recovery and discharge methods while accounting for cumulative regional impacts. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
asia
indonesia
desalination
brine
ocean
governance
under
geopolitical
fragmentation
growing
produce
concentrated
technology-computing
economics-resources
climate-environment
systems
quantum
If people live substantially longer, societies will need new models for work, learning, housing, dependency, and end-of-life care. Existing systems are not designed for decades of post-retirement life or multiple phases of dependency. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
thailand
care
infrastructure
extreme
longevity
under
geopolitical
fragmentation
dependency
people
live
technology-computing
climate-environment
systems
society-governance
quantum
Lunar infrastructure and resource extraction could create new strategic inequalities. The challenge is developing rules that enable science and commercial activity while protecting shared interests and preventing territorial competition. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
oceania
australia
access
lunar
equitable
scientific
resources
under
geopolitical
fragmentation
create
infrastructure
technology-computing
climate-environment
society-governance
systems
quantum
open
United States, North America
Autonomous spacecraft may make split-second avoidance decisions using imperfect data and proprietary software. The unresolved problem is assigning responsibility, proving fault, and compensating affected parties across jurisdictions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
north-america
united-states
autonomous
spacecraft
liability
collisions
under
geopolitical
fragmentation
data
may
make
economics-resources
climate-environment
society-governance
systems
infrastructure
open
South Africa, Africa
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
africa
south-africa
standards
ai-designed
proteins
under
geopolitical
fragmentation
deployment
biological
molecules
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
asia
india
feedstocks
biomanufacturing
non-food
under
geopolitical
fragmentation
large-scale
fermentation
may
compete
technology-computing
economics-resources
society-governance
systems
infrastructure
Biological design tools are becoming more accessible while oversight remains fragmented across countries and institutions. The challenge is detecting dangerous activity without suppressing legitimate research or creating an intrusive global surveillance system. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
asia
india
monitoring
synthetic
biology
risk
under
geopolitical
fragmentation
design
research
technology-computing
economics-resources
society-governance
climate-environment
systems
infrastructure
Quantum capabilities could transform optimization, chemistry, intelligence, and cryptanalysis while becoming concentrated in a few states. The challenge is preventing destabilizing secrecy and unequal access without blocking peaceful scientific collaboration. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
asia
india
quantum
international
governance
advantage
under
geopolitical
fragmentation
access
capabilities
transform
technology-computing
economics-resources
climate-environment
systems
infrastructure
open
European Union, Europe
Frontier AI may become essential infrastructure controlled by a small number of governments or companies. The unresolved task is developing ownership, access, competition, and public-interest models that prevent private or geopolitical concentration from determining global outcomes. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
europe
european-union
concentration
geopolitical
preventing
advanced
decision
power
under
fragmentation
access
frontier
technology-computing
economics-resources
climate-environment
systems
infrastructure
Future infrastructure will increasingly rely on systems capable of making decisions without immediate human supervision. The unresolved problem is creating architectures that can prove what they did, explain uncertainty, fail safely, and remain controllable during abnormal conditions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
infrastructure
auditable
autonomy
critical
under
geopolitical
fragmentation
remain
future
will
technology-computing
society-governance
climate-environment
systems
quantum
open
South America / Unspecified, South America
Citizens feel democracy is not delivering security or prosperity, driving support for radical solutions and coups. Civic-engagement platforms and institutional-performance dashboards can rebuild trust.
society-governance
south-america
south-america-unspecified
social
fragmentation
distrust
institutions
rising
south
american
countries
citizens
feel
public
trust
data
registries
governance
open
South America / Unspecified, South America
Shifting alliances and instability weaken regional organisations’ capacity to coordinate policy. Governance-analytics tools and flexible cooperation frameworks could support more resilient integration.
society-governance
south-america
south-america-unspecified
regional
cooperation
mechanisms
south
america
struggle
political
fragmentation
shifting
alliances
global-unspecified
african
local-regional
asia
remains
open
Global / Unspecified, Global
Dust growth, fragmentation, and migration shape planet formation but are complex. Combined observation and modeling efforts are needed.
social-civic-problems
global-unspecified
dust
lack
detailed
models
evolution
protoplanetary
disks
growth
fragmentation
migration
science-space
fully
climate-environment
formation
interstellar
open
Global / Unspecified, Global
Sprawl cuts off wildlife movement. Green infrastructure and planning can mitigate fragmentation.
climate-environment
global-unspecified
urban
expansion
fragments
natural
habitats
sprawl
cuts
off
wildlife
movement
african
cities
systems
informal
haven
planning
open
South & Southeast Asia, Asia
Inheritance customs split land across generations, leaving average farm sizes shrinking below profitable thresholds. Cooperative farming models and land-pooling platforms could restore economies of scale.
economics-resources
asia
south-southeast-asia
land
fragmentation
making
farms
too
small
economically
viable
asian
countries
global-unspecified
society-governance
remain
communities
african
Founders outside major hubs often cannot easily expand into neighboring markets due to regulatory fragmentation. Harmonized regional startup-friendly regulations could enable faster cross-border scaling.
society-governance
asia
regional
scaling
startups
smaller
economies
face
limited
access
opportunities
african
global-unspecified
remains
local-regional
africa
countries
economics-resources
Complex, legacy land ownership patterns in urban centers make land assembly prohibitively expensive for municipal social housing development.
local-regional
asia
thailand
land
urban
social
housing
haven
solved
fragmentation
impeding
large-scale
affordable
global-unspecified
society-governance
cities
social-civic-problems
climate-environment