World Solve

Current approaches to interventions that reduce the burden of infectious diseases through environmental and behavioral action either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for institutional designs for managing the global commons of the high seas and outer space creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to therapies that extend healthspan by targeting fundamental aging processes either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for materials and processes for recycling complex multi-material products at high purity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for mechanisms for ensuring that climate finance is additional to existing development assistance creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to planetary protection detection for forward and backward contamination either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for governance frameworks for the responsible development of advanced neurotechnology creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for materials enabling reversible CO2 capture and conversion to useful products creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for adaptive literacy systems closing gaps in multilingual low-resource classrooms creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for governance models for shared management of transboundary aquifers and rivers creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to nature-based solutions for landslide and erosion control on steep agricultural lands either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for methods for restoring coastal wetlands that maximize both carbon and biodiversity co-benefits creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for systems ensuring the safety and reliability of autonomous systems in healthcare delivery creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for complete proteins from agricultural lignocellulosic residues creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for methods for assessing the resilience of food systems to simultaneous climate and geopolitical shocks creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for methods for quantifying the health co-benefits of different climate mitigation strategies creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to restoration techniques for coral reefs that succeed under ongoing ocean warming and acidification either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for biotechnologies for engineering microbes that produce biodegradable alternatives to conventional plastics creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to neighborhood-scale wastewater systems recovering phosphorus and energy either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to governance models for the equitable sharing of benefits from space resource utilization either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.