Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Fast charging speeds up daily convenience but tends to accelerate battery wear, forcing a tradeoff between speed and battery lifespan. Solving this without expensive materials remains an unresolved engineering challenge.
economics-resources
global-unspecified
fast
build
batteries
charge
filling
gas
tank
degrading
quickly
battery
whether
philosophy-ethics
mathematics-logic
haven
technology-computing
climate-environment
open
Global / Unspecified, Global
Robots can now handle many industrial tasks well, but tasks requiring soft, adaptable touch, like handling fabric or fragile objects, remain surprisingly difficult. Closing this dexterity gap would open robotics to far more everyday uses.
climate-environment
global-unspecified
tasks
robots
dexterity
like
yet
build
fine
motor
needed
delicate
technology-computing
affordable
philosophy-ethics
whether
capable
open
Global / Unspecified, Global
Over the next two decades, rising resistance in bacteria, fungi, and parasites risks undermining surgery, chemotherapy, and intensive care. Global surveillance networks, rapid diagnostics, and new antimicrobial development platforms are crucial to avert a post-antibiotic era.
health-biology
global-unspecified
antimicrobial
resistance
over
next
decades
make
routine
infections
deadly
again
will
data
climate-environment
society-governance
infrastructure
europe
open
Global / Unspecified, Global
Ageing populations, urban diets, and pollution will drive surges in cardiovascular disease, diabetes, cancer, and chronic respiratory conditions. Scalable chronic-care models, digital coaching tools, and preventive policy reforms are needed.
society-governance
global-unspecified
policy-reform
will
non-communicable
diseases
dominate
mortality
low-income
countries
2040
ageing
populations
health-biology
health
climate-environment
non
communicable
open
Global / Unspecified, Global
By the 2030s and 2040s, extreme heat and shifting mosquito ranges will expand malaria, dengue, and other infections into new regions. Heat-health early-warning systems and climate-sensitive disease-modelling platforms must be deployed.
health-biology
global-unspecified
climate-change
will
climate
change
amplify
heat-related
illness
vector-borne
diseases
2030s
2040s
climate-environment
society-governance
systems
governance
building
open
Global / Unspecified, Global
Rising stress, social isolation, and economic precarity will increase depression, anxiety, and cognitive disorders, especially among youth. Scalable digital therapeutics and integrated community mental-health ecosystems are needed.
economics-resources
global-unspecified
mental-health
health
disorders
will
among
mental
neurodevelopmental
largest
burdens
variant
health-biology
society-governance
data
african
technology-computing
climate-environment
open
Global / Unspecified, Global
AI tools will increasingly support diagnosis and triage, but biases and opaque models may harm patients. Transparent validation frameworks, audit trails, and clinician–AI training curricula will be key.
society-governance
global-unspecified
will
human
collaboration
clinical
decision-making
need
rigorous
oversight
tools
increasingly
climate-environment
health-biology
systems
climate
technology-computing
without
open
Global / Unspecified, Global
AI tools will increasingly support diagnosis and triage, but biases and opaque models may harm patients. Transparent validation frameworks, audit trails, and clinician–AI training curricula will be key.
climate-environment
global-unspecified
will
human
collaboration
clinical
decision-making
need
rigorous
oversight
variant
focuses
society-governance
infrastructure
data
technology-computing
health-biology
climate
open
Global / Unspecified, Global
Electronic health record silos, uneven standards, and privacy concerns will hinder cross-institutional analytics. Federated learning, privacy-preserving linkage, and open standards could unlock insights.
society-governance
global-unspecified
will
learning
health
data
interoperability
remain
bottleneck
systems
standards
electronic
open
public
technical
technology-computing
health-biology
climate-environment
open
Global / Unspecified, Global
mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.
health-biology
global-unspecified
must
next-generation
vaccine
platforms
ready
respond
weeks
new
threats
variant
infrastructure
will
climate-environment
data
technology-computing
society-governance
open
Global / Unspecified, Global
Mega-cities will produce unique mixtures of traffic accidents, air pollution, and sedentary lifestyles. Urban health observatories and built-environment intervention tools will be critical.
climate-environment
global-unspecified
air-pollution
will
pollution
urbanisation
drive
new
patterns
injury
exposure
lifestyle
disease
health
health-biology
air
african
open
Global / Unspecified, Global
Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.
health-biology
global-unspecified
will
metabolic
food-system
transformations
reshape
human
microbiomes
health
ultra-processed
foods
climate-environment
new
society-governance
technology-computing
food
system
open
Global / Unspecified, Global
Resistance genes move through soil, water, and food chains, making hospital-focused interventions insufficient. One-Health regulatory frameworks and monitoring tools are required.
climate-environment
global-unspecified
antibiotic
stewardship
will
need
extend
beyond
hospitals
agriculture
environment
resistance
water
human
society-governance
real
haven
food
open
Global / Unspecified, Global
Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.
climate-environment
global-unspecified
therapies
new
cancer
will
demand
better
real-world
data
understand
long-term
society-governance
public
registries
health-biology
governance
technology-computing
open
Global / Unspecified, Global
Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.
climate-environment
global-unspecified
data
therapies
new
cancer
will
demand
better
real-world
understand
long-term
society-governance
technology-computing
infrastructure
african
systems
europe
open
Global / Unspecified, Global
Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.
health-biology
global-unspecified
mental-health
will
climate-linked
displacement
create
new
health-service
needs
migrants
variant
focuses
health
infrastructure
data
society-governance
climate-environment
open
Global / Unspecified, Global
Over the next 10–20 years, biosensors will track vital signs, metabolites, and behaviours, but analytics and integration into care will lag. Edge-computing and clinically validated algorithms will be needed.
technology-computing
global-unspecified
will
wearable
implantable
sensors
generate
continuous
health
data
underused
over
health-biology
climate-environment
society-governance
climate
new
economics-resources
open
Global / Unspecified, Global
Poor-quality medicines accelerate resistance and treatment failure. Track-and-trace systems and quality-testing infrastructure are needed.
health-biology
global-unspecified
resistance
antimicrobial
low-resource
settings
will
exacerbated
counterfeit
substandard
drugs
poor-quality
systems
society-governance
climate-environment
infrastructure
technology-computing
economics-resources
open
Global / Unspecified, Global
Models may generate candidate molecules rapidly, challenging traditional assessment. Simulation-based validation and adaptive regulatory frameworks will be needed.
society-governance
global-unspecified
will
regulatory
ai-designed
drugs
require
new
science
approaches
models
may
governance
health-biology
climate-environment
technology-computing
health
frameworks
open
Global / Unspecified, Global
Bioprinting and stem-cell therapies may not scale fast enough to meet demand. Organ-allocation optimisation and cross-border sharing platforms remain important.
health-biology
global-unspecified
may
future
organ
shortage
crises
persist
despite
advances
regenerative
medicine
climate-environment
technology-computing
food
whether
philosophy-ethics
microbial
