World Solve

Create field-deployable chemical verification methods that pharmacies, regulators, and patients can use to distinguish authentic cancer drugs from counterfeit or degraded products.

Despite recognition of its importance, reliable methods for integrated wildlife-livestock-human zoonotic spillover surveillance are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for distributed methane leak detection and auto-mitigation systems. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Achieving early warning systems for social unrest linked to climate and resource stress at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

A persistent gap exists in realizing practical, scalable solutions for education and training systems that prepare populations for climate-driven livelihood transitions. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for behavioral and structural interventions reducing food loss in tropical value chains are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for institutional arrangements that improve coordination between health climate and development sectors are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for institutional designs that make long-term infrastructure investment politically durable creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for nature-based solutions for urban stormwater that also enhance biodiversity and amenity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for safe and effective methods for large-scale insect protein production and use are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for passive cooling and ventilation systems for informal settlement housing are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for solutions for providing high-quality mental health care in primary care and community settings are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for real-time systems for detecting and responding to the illegal trade in timber and forest products. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for real-time attribution of extreme weather events to climate change for adaptation planning. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Achieving early childhood development programs proven effective at national scale under fiscal constraint at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

The absence of robust, context-adapted solutions for therapeutics and care models that improve outcomes for people living with multimorbidity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for circular nutrient management systems closing phosphorus loops at regional scale creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Achieving methods for restoring the carbon sequestration capacity of terrestrial and coastal ecosystems at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Despite recognition of its importance, reliable methods for biotechnologies converting methane and CO2 into high-value chemicals and proteins are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for autonomous microgravity assembly of large habitats and infrastructure creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.