The problem of mass unemployment and underemployment continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
mass
unemployment
underemployment
scaling
successful
other
The problem of unequal treatment of boys and girls in schools and homes continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
unequal
treatment
boys
girls
schools
other
The problem of lack of clean and safe drinking water continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
lack
clean
safe
drinking
water
other
When personal memory archives exist solely in distributed cloud systems, sudden or gradual data loss can erase formative experiences without local backups. The challenge is building durable, verifiable, and accessible long-term personal memory infrastructure that survives corporate failure, format obsolescence, and account lapses. Solutions should remain affordable, user-controlled, and recoverable even decades later.
cloud
systems
ensuring
childhood
memories
other
The problem of children going to bed hungry every night continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
sustainable
children
going
bed
hungry
other
Astronomy, cultural practices, wildlife, and human sleep may be affected by large satellite fleets. A workable solution must reconcile connectivity goals with brightness limits, orbital design, and international compliance. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
science-space
satellite
preserving
dark
skies
during
expansion
low-income
communities
solution
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
safe
open
United States, North America
As digital navigation layers become permanent fixtures in daily life, physical landmarks lose meaning and people lose the ability to orient themselves without screens. The challenge is creating systems or practices that preserve spatial awareness and independent wayfinding while still allowing beneficial digital tools. Solutions must work across cultures, age groups, and infrastructure levels, avoid creating new dependencies, and remain usable when networks fail.
digital
physical
navigation
preventing
erosion
technology-computing
Lunar infrastructure and resource extraction could create new strategic inequalities. The challenge is developing rules that enable science and commercial activity while protecting shared interests and preventing territorial competition. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
oceania
australia
access
lunar
equitable
scientific
resources
under
geopolitical
fragmentation
create
infrastructure
technology-computing
climate-environment
society-governance
systems
quantum
Lunar infrastructure and resource extraction could create new strategic inequalities. The challenge is developing rules that enable science and commercial activity while protecting shared interests and preventing territorial competition. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
lunar
equitable
access
scientific
resources
low-income
communities
create
infrastructure
resource
technology-computing
climate-environment
society-governance
systems
quantum
open
Mexico, North America
As identity, payments, records, and service portals become central to state capacity, failures will produce large-scale disputes. The unresolved problem is setting up fast, fair, and trusted systems to resolve them. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
north-america
mexico
state-capacity
institutions
public
informal
settlements
creating
dispute
resolution
digital
infrastructure
fair
systems
technology-computing
governance
Urban growth, migration, and climate change will outpace traditional master planning. The challenge is designing governance that can revise land use, service delivery, and infrastructure priorities continuously without becoming arbitrary. This becomes particularly difficult in post-conflict institutions, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
asia
bangladesh
climate-change
institutions
governance
change
post-conflict
building
cities
faster
plans
urban
growth
public
climate-environment
systems
conflict
open
United States, North America
Autonomous spacecraft may make split-second avoidance decisions using imperfect data and proprietary software. The unresolved problem is assigning responsibility, proving fault, and compensating affected parties across jurisdictions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
north-america
united-states
autonomous
spacecraft
liability
collisions
under
geopolitical
fragmentation
data
may
make
economics-resources
climate-environment
society-governance
systems
infrastructure
Autonomous spacecraft may make split-second avoidance decisions using imperfect data and proprietary software. The unresolved problem is assigning responsibility, proving fault, and compensating affected parties across jurisdictions. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
autonomous
spacecraft
liability
collisions
low-income
communities
may
make
split-second
avoidance
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
science-space
Severe solar storms can disrupt satellites, power grids, navigation, aviation, and communication networks. Future resilience requires better forecasting, hardened systems, coordinated shutdown procedures, and affordable protection for developing countries. Affected communities must have meaningful control over data, revenue, deployment decisions, and the right to refuse harmful applications. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
science-space
protection
space
weather
infrastructure
community
ownership
deployment
severe
solar
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
safe
without
Industrial agriculture, pollution, and habitat loss may eliminate microorganisms with future medical and ecological value before they are studied. The challenge is creating ethical, distributed microbial conservation infrastructure. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
health-biology
microbial
future
preserving
diversity
medicine
low-income
communities
industrial
agriculture
pollution
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
quantum
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. The approach must scale before formal institutions, infrastructure, and land-use systems fully catch up with population growth. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
asia
india
ai-designed
standards
proteins
rapidly
urbanizing
regions
deployment
approach
biological
technology-computing
society-governance
economics-resources
climate-environment
systems
infrastructure
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. Affected communities must have meaningful control over data, revenue, deployment decisions, and the right to refuse harmful applications. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
ai-designed
deployment
standards
proteins
community
ownership
biological
molecules
may
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
quantum
science-space
open
South Africa, Africa
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
africa
south-africa
standards
ai-designed
proteins
under
geopolitical
fragmentation
deployment
biological
molecules
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
asia
india
feedstocks
biomanufacturing
non-food
under
geopolitical
fragmentation
large-scale
fermentation
may
compete
technology-computing
economics-resources
society-governance
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
feedstocks
biomanufacturing
non-food
low-income
communities
large-scale
fermentation
may
compete
food
technology-computing
economics-resources
society-governance
systems
infrastructure
quantum
safe