World Solve

A persistent gap exists in realizing practical, scalable solutions for therapeutics targeting the shared biological pathways underlying multiple chronic diseases. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for near-ambient reversible hydrogen storage with high volumetric density. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for methods for assessing the cumulative impacts of multiple environmental stressors on ecosystems. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for interventions that close gender and socioeconomic gaps in access to digital technologies. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to real-time systems for predicting and mitigating the impacts of extreme precipitation events either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for field-deployable PFAS-degrading microbial or catalytic consortia. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for institutional arrangements that reduce the lag between innovation and equitable access to health technologies. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for interventions that improve the quality of democratic participation and representation. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for protocols for the responsible conduct of research involving human enhancement technologies. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for biotechnologies for engineering microbes that degrade persistent environmental pollutants. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to methods for quantifying the full life-cycle impacts of different renewable energy technologies either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for design principles for cities that remain livable under 3 C of global warming. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to governance frameworks for the responsible use of genetic data in health and ancestry applications either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to protocols for safe and equitable sharing of pathogen genetic sequence data either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to education approaches that build the skills needed for green jobs and sustainable entrepreneurship either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for technologies enabling continuous monitoring of biodiversity in remote and marine ecosystems. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for designs for transportation systems that remain functional under extreme weather and energy constraints. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to protocols for the ethical conduct of research involving advanced AI systems and human subjects either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Current approaches to solutions for safe and equitable management of the growing volumes of nuclear waste either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for institutional designs that increase public trust in scientific institutions and advice. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.