World Solve

Despite recognition of its importance, reliable methods for inclusive digital public infrastructure resistant to both outages and capture are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Create scientific and economic models that overcome the lack of commercial incentives for new antibiotics while ensuring equitable global access.

Develop point-of-care diagnostics for invasive and drug-resistant fungal infections, especially among immunocompromised patients in regions lacking advanced laboratories.

Develop tamper-resistant, ultra-low-cost monitoring and backup cooling systems for vaccines, insulin, biologics, and diagnostic reagents where electricity failures are frequent.

Tuberculosis treatment in Mexico requires six or more months of consistent dosing, but migrant and seasonal workers frequently relocate mid-treatment, breaking continuity of care and driving drug-resistant strains.

Current approaches to neutron-resistant fusion blanket and structural materials either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Philippines lacks a distributed, low-cost surveillance network to detect emerging drug-resistant pathogens before they spread between hospitals, leaving clinicians to prescribe empirically rather than on real-time resistance data.

Despite recognition of its importance, reliable methods for participatory budgeting designs resistant to elite and algorithmic capture are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving decentralized identity resistant to state and AI-generated forgery at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Despite recognition of its importance, reliable methods for quantum-resistant cryptography practical for constrained critical IoT are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.