World Solve

Create affordable, rapid diagnostics and clinical protocols for agricultural poisonings where symptoms overlap with infections and chemical testing is inaccessible.

Build ethical, affordable systems to monitor animal handlers, farms, markets, and wildlife interfaces for pathogens with pandemic potential before sustained human transmission begins.

Create clinically sound pathways, tools, and training that reduce years-long delays in diagnosis and treatment for endometriosis where specialist care is scarce.

Develop accessible monitoring for silica dust exposure and early lung damage among artisanal miners and construction workers who lack occupational health coverage.

Design care models that maintain treatment continuity for migrants, truck drivers, seasonal workers, and displaced people who routinely cross administrative boundaries.

Create portable screening methods and referral systems that detect hearing loss early in communities without audiologists or specialized diagnostic equipment.

Develop scalable rehabilitation systems that combine community workers, telemedicine, low-cost devices, and culturally appropriate exercises for stroke survivors far from specialists.

Create robust low-resource triage systems that recognize early sepsis using inexpensive sensors, clinical workflows, and locally calibrated machine-learning models.

Determine how heat, dehydration, pesticide exposure, and labor conditions interact to cause chronic kidney disease, then build practical prevention systems for agricultural and construction workers.

Develop point-of-care diagnostics for invasive and drug-resistant fungal infections, especially among immunocompromised patients in regions lacking advanced laboratories.

Create accurate, validated screening tools that detect dangerous neonatal bilirubin levels in homes and rural clinics without requiring expensive laboratory equipment.

Design clinically reliable decision-support tools using basic vitals, history, and low-cost tests to identify high-risk pregnancies before preventable postpartum hemorrhage occurs.

Create field-deployable chemical verification methods that pharmacies, regulators, and patients can use to distinguish authentic cancer drugs from counterfeit or degraded products.

Develop tamper-resistant, ultra-low-cost monitoring and backup cooling systems for vaccines, insulin, biologics, and diagnostic reagents where electricity failures are frequent.

Build low-cost metagenomic and biosensor systems that identify emerging resistance genes in sewage networks early enough for hospitals and public-health agencies to alter treatment protocols.

Survivors of gender-based violence in Ukraine frequently avoid reporting due to social stigma, distrust of law enforcement, and lack of confidential support services in their communities.

Despite recognition of its importance, reliable methods for solutions for providing high-quality mental health care in primary care and community settings are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Children displaced from Yemen frequently experience multi-year gaps in schooling because host communities lack accredited pathways to integrate them into local education systems.

Achieving interventions that improve mental health and social cohesion in rapidly urbanizing populations at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Despite recognition of its importance, reliable methods for interventions that reduce the prevalence of non-communicable diseases through population-level action are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.