Cities may deploy scent systems that automatically adjust collective emotional states. Over time some residents develop tolerance or adverse reactions, creating uneven effects and new forms of environmental inequality. The problem is designing transparent, opt-outable, and medically safe atmospheric interventions that do not become tools of coercion or social control.
scent
managing
public
emitters
alter
health-biology
The problem of lack of clean and safe drinking water continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
lack
clean
safe
drinking
water
other
The problem of children going to bed hungry every night continues to affect hundreds of millions of people and undermines progress on multiple Sustainable Development Goals. Existing responses remain fragmented, under-resourced and poorly adapted to local contexts. A strong solution must operate effectively under severe constraints of skilled personnel, infrastructure, electricity and connectivity. It should define clear measurable outcomes, identify possible unintended harms, and demonstrate how the intervention can be sustained by local institutions long after initial funding ends.
sustainable
children
going
bed
hungry
other
Astronomy, cultural practices, wildlife, and human sleep may be affected by large satellite fleets. A workable solution must reconcile connectivity goals with brightness limits, orbital design, and international compliance. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
science-space
satellite
preserving
dark
skies
during
expansion
low-income
communities
solution
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
safe
open
United States, North America
As digital navigation layers become permanent fixtures in daily life, physical landmarks lose meaning and people lose the ability to orient themselves without screens. The challenge is creating systems or practices that preserve spatial awareness and independent wayfinding while still allowing beneficial digital tools. Solutions must work across cultures, age groups, and infrastructure levels, avoid creating new dependencies, and remain usable when networks fail.
digital
physical
navigation
preventing
erosion
technology-computing
Lunar infrastructure and resource extraction could create new strategic inequalities. The challenge is developing rules that enable science and commercial activity while protecting shared interests and preventing territorial competition. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
lunar
equitable
access
scientific
resources
low-income
communities
create
infrastructure
resource
technology-computing
climate-environment
society-governance
systems
quantum
open
Mexico, North America
As identity, payments, records, and service portals become central to state capacity, failures will produce large-scale disputes. The unresolved problem is setting up fast, fair, and trusted systems to resolve them. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
north-america
mexico
state-capacity
institutions
public
informal
settlements
creating
dispute
resolution
digital
infrastructure
fair
systems
technology-computing
governance
Urban growth, migration, and climate change will outpace traditional master planning. The challenge is designing governance that can revise land use, service delivery, and infrastructure priorities continuously without becoming arbitrary. This becomes particularly difficult in post-conflict institutions, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
asia
bangladesh
climate-change
institutions
governance
change
post-conflict
building
cities
faster
plans
urban
growth
public
climate-environment
systems
conflict
Autonomous spacecraft may make split-second avoidance decisions using imperfect data and proprietary software. The unresolved problem is assigning responsibility, proving fault, and compensating affected parties across jurisdictions. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
autonomous
spacecraft
liability
collisions
low-income
communities
may
make
split-second
avoidance
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
science-space
Future governments will need near-real-time visibility into commitments, arrears, off-budget liabilities, and contingent risks. The open problem is building financial transparency systems that ordinary citizens and auditors can actually use. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
asia
bangladesh
public
informal
settlements
making
finance
legible
real
time
risks
future
institutions
systems
climate-environment
governance
open
United States, North America
Thousands of satellites may provide connectivity while increasing collision risk, radio interference, light pollution, and disposal complexity. The challenge is creating enforceable coordination and end-of-life standards across commercial and state operators. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
north-america
united-states
managing
orbital
congestion
mega-constellations
low-income
communities
thousands
satellites
may
provide
technology-computing
economics-resources
society-governance
systems
quantum
As more government activity moves online, corruption may shift from visible cash handling to invisible data manipulation, access control, and procurement capture. The challenge is detecting abuse in systems that look efficient on the surface. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
resilient
systems
informal
settlements
creating
anti-corruption
digital
states
government
activity
public
technology-computing
institutions
across
corruption
open
Brazil, South America
Research environments may unintentionally create or amplify resistance traits that escape through waste, personnel, or supply chains. Robust solutions must combine laboratory engineering, surveillance, waste treatment, and international reporting. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
south-america
brazil
supply-chain
resistance
controlling
antimicrobial
synthetic
biology
laboratories
low-income
communities
research
create
technology-computing
climate-environment
society-governance
systems
Public services will increasingly depend on rapidly updated models and decision pipelines. The unresolved problem is keeping these systems lawful, understandable, and corrigible as they evolve faster than formal regulations. This becomes particularly difficult in informal settlements, because public institutions must remain fair, resilient, and accountable while adapting to new risks.
society-governance
africa
nigeria
public
services
informal
settlements
designing
adaptable
governance
emerging
will
increasingly
systems
institutions
technology-computing
Industrial agriculture, pollution, and habitat loss may eliminate microorganisms with future medical and ecological value before they are studied. The challenge is creating ethical, distributed microbial conservation infrastructure. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
health-biology
microbial
future
preserving
diversity
medicine
low-income
communities
industrial
agriculture
pollution
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
quantum
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
feedstocks
biomanufacturing
non-food
low-income
communities
large-scale
fermentation
may
compete
food
technology-computing
economics-resources
society-governance
systems
infrastructure
quantum
safe
open
Brazil, South America
Genomic medicine could improve treatment while enabling insurers, employers, states, or platforms to infer sensitive traits. The challenge is ensuring people benefit from precision medicine without losing control over biological information. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
south-america
brazil
medicine
personalized
genetic
discrimination
low-income
communities
genomic
improve
treatment
while
economics-resources
climate-environment
society-governance
systems
quantum
Engineered microbes, insects, crops, and gene drives may offer major ecological benefits but could spread beyond intended boundaries. The unresolved problem is developing reversible, monitorable, and internationally governed release frameworks. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
release
engineered
safe
environmental
organisms
low-income
communities
microbes
insects
crops
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
open
Brazil, South America
Future outbreaks may involve pathogens for which no profitable commercial market exists. A useful solution requires distributed manufacturing, adaptable platforms, pre-negotiated procurement, and equitable access before an outbreak occurs. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
south-america
brazil
manufacturing
pathogens
market
rapid
vaccine
existing
low-income
communities
solution
future
technology-computing
climate-environment
society-governance
systems
quantum
Biological design tools are becoming more accessible while oversight remains fragmented across countries and institutions. The challenge is detecting dangerous activity without suppressing legitimate research or creating an intrusive global surveillance system. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
monitoring
synthetic
biology
risk
low-income
communities
research
biological
design
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
science-space