Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Postpartum depression affects many new parents, often going undiagnosed until it significantly affects their wellbeing and their child's early development. Better early prediction could allow support to begin before symptoms take hold.
health-biology
global-unspecified
postpartum
depression
don
have
reliable
way
predict
prevent
develops
affects
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Food allergy rates have been rising for decades, and the exact reasons behind this trend remain only partially understood. Understanding the cause could help prevent, not just manage, this growing health issue.
climate-environment
global-unspecified
food
yet
stop
allergies
becoming
common
children
worldwide
allergy
rates
whether
philosophy-ethics
health-biology
way
determine
resolved
open
United States, North America
Because rare diseases affect few patients, there's often little financial incentive for researchers or companies to develop treatments. Thousands of rare conditions remain effectively untreated as a direct result.
health-biology
north-america
united-states
rare
diseases
don
have
cure
genetic
affecting
small
patient
populations
philosophy-ethics
global-unspecified
whether
determine
resolved
open
Global / Unspecified, Global
Countries with opt-out organ donation systems tend to have far higher donation rates, saving more lives, but implementing this fairly and ethically worldwide remains politically and culturally difficult.
philosophy-ethics
global-unspecified
donation
organ
opt-out
fairly
haven
found
way
make
not
opt-in
whether
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Existing dementia treatments offer only modest, temporary relief from symptoms rather than meaningfully slowing the underlying disease. A real disease-modifying treatment remains one of medicine's most sought-after breakthroughs.
health-biology
global-unspecified
treatment
dementia
don
have
widely
available
slows
progression
forms
existing
philosophy-ethics
whether
determine
way
resolved
agreed
open
Global / Unspecified, Global
Sepsis can escalate from a treatable infection to a life-threatening emergency within hours, and current diagnosis often catches it too late. Faster detection tools could dramatically reduce sepsis deaths in hospitals.
health-biology
global-unspecified
sepsis
haven
solved
detect
early
enough
prevent
becoming
fatal
escalate
whether
philosophy-ethics
way
determine
open
Global / Unspecified, Global
Once the tiny hair cells in the inner ear are damaged, human bodies can't naturally regrow them, making most hearing loss permanent. Cell regeneration therapies show early promise but remain far from mainstream treatment.
health-biology
global-unspecified
hearing
loss
yet
reverse
caused
aging
long-term
noise
exposure
once
whether
philosophy-ethics
don
determine
prevent
way
open
Global / Unspecified, Global
Genetic testing can reveal risk for serious inherited conditions, but cost and access limit it mostly to wealthier patients and countries. Broader affordability could catch preventable conditions far earlier for many more people.
health-biology
global-unspecified
genetic
testing
don
have
affordable
available
everyone
benefit
conditions
reveal
whether
philosophy-ethics
determine
resolved
agreed
way
open
Global / Unspecified, Global
Autoimmune arthritis causes the body's own immune system to damage joint tissue, leading to chronic pain and disability. Current treatments manage inflammation but don't address why the immune system attacks in the first place.
health-biology
global-unspecified
immune
system
arthritis
haven
found
way
stop
attacking
healthy
joints
whether
philosophy-ethics
resolved
mathematics-logic
determine
don
open
Global / Unspecified, Global
Tinnitus affects a significant portion of the population and can seriously impact quality of life, yet current treatments only manage symptoms rather than eliminate the underlying cause.
health-biology
global-unspecified
tinnitus
don
have
reliable
cure
constant
ringing
some
people
hear
philosophy-ethics
whether
determine
resolved
way
mathematics-logic
open
Global / Unspecified, Global
A small number of people show natural resistance to certain infections or conditions, and understanding why could reveal entirely new treatment approaches. This resistance remains only partially understood at a genetic level.
health-biology
global-unspecified
people
haven
solved
some
naturally
resistant
diseases
affect
nearly
everyone
philosophy-ethics
whether
mathematics-logic
resolved
determine
know
open
Global / Unspecified, Global
Unlike infectious diseases, cancer arises from a person's own cells mutating, making a universal vaccine far more complex to design. Progress exists for a few cancer types, but a broadly effective approach remains unsolved.
health-biology
global-unspecified
infectious-disease
cancer
effective
vaccine
types
don
have
unlike
infectious
diseases
arises
whether
philosophy-ethics
determine
way
resolved
open
Global / Unspecified, Global
Artificial lighting confuses migration patterns, hunting behavior, and reproduction cycles in many nocturnal species, yet city lighting keeps expanding with growth. A widely adopted, wildlife-friendly lighting standard remains missing.
climate-environment
global-unspecified
nocturnal
lighting
haven
solved
prevent
light
pollution
disrupting
wildlife
growing
whether
philosophy-ethics
mathematics-logic
way
resolved
determine
open
Global / Unspecified, Global
Rivers often flow through multiple countries, and disputes over how much water each country can use remain a persistent source of tension. A widely accepted, fair sharing framework remains unbuilt in many major river basins.
climate-environment
global-unspecified
fair
water
countries
river
don
have
way
manage
rights
between
whether
philosophy-ethics
determine
resolved
agreed
haven
open
Global / Unspecified, Global
Poor farming practices and deforestation are wearing away fertile topsoil faster than nature can rebuild it, threatening long-term food production. A scalable solution to reverse this trend remains unresolved globally.
climate-environment
global-unspecified
deforestation
yet
stop
soil
erosion
steadily
reducing
farmland
productivity
worldwide
poor
philosophy-ethics
whether
way
mathematics-logic
haven
open
Global / Unspecified, Global
Algae blooms can quickly poison drinking water sources, sometimes going undetected until people or animals get sick. Faster, cheaper detection methods could prevent this from becoming a public health crisis.
health-biology
global-unspecified
public-health
algae
blooms
water
don
have
reliable
affordable
way
detect
toxic
whether
philosophy-ethics
determine
resolved
agreed
open
United States, North America
Wave energy is abundant and largely untapped, but current technology to harness it reliably and affordably lags far behind wind and solar. Cracking this could add a major renewable source to the global energy mix.
climate-environment
north-america
united-states
energy
wave
don
have
efficient
way
convert
ocean
usable
electricity
global-unspecified
whether
philosophy-ethics
mathematics-logic
determine
open
Global / Unspecified, Global
Bees and other pollinators face combined pressure from pesticides, habitat loss, and disease, and addressing just one threat rarely solves the overall decline. A comprehensive solution addressing all major threats together remains unbuilt.
health-biology
global-unspecified
threats
face
haven
found
way
protect
pollinator
populations
multiple
once
philosophy-ethics
whether
prevent
determine
mathematics-logic
resolved
open
Global / Unspecified, Global
In hot, dry climates, a significant portion of irrigation water is lost to evaporation before it ever reaches crop roots. Affordable ways to reduce this loss could ease water stress in agriculture-heavy dry regions.
climate-environment
global-unspecified
water
dry
lost
evaporation
regions
don
have
cheap
technology
capture
whether
philosophy-ethics
urban
determine
agreed
open
Global / Unspecified, Global
Wetlands filter water and protect against flooding, but restoring one once it's been drained or built over is far harder than protecting it in the first place. Better restoration techniques remain limited and expensive.
climate-environment
global-unspecified
have
wetlands
been
don
reliable
way
restore
destroyed
development
filter
whether
philosophy-ethics
determine
resolved
agreed
prevent
