World Solve

Dengue surveillance in Brazil is largely retrospective, relying on confirmed case counts reported weeks after transmission has already accelerated, rather than integrating mosquito density, rainfall, and mobility data into a forward-looking model.

Current approaches to low-energy nitrogen fixation alternatives to Haber-Bosch at farm scale either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for governance models for ensuring the equitable distribution of benefits from AI and automation. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for biotechnologies for engineering crops that are more resilient to pests and diseases under climate change. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to methods for quantifying the full costs of inaction on climate change biodiversity loss and pollution either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

A persistent gap exists in realizing practical, scalable solutions for technologies enabling the continuous monitoring of biodiversity and ecosystem function at scale. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for solutions for managing the growing volumes of electronic and battery waste are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for high-throughput breeding platforms for climate-resilient orphan crops creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for interventions that close gender and socioeconomic gaps in access to digital technologies. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

The absence of robust, context-adapted solutions for participatory sensing networks for air quality in rapidly industrializing cities creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for regenerative approaches to reverse age-related decline in muscle and cognition are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving decentralized identity resistant to state and AI-generated forgery at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

The absence of robust, context-adapted solutions for materials and processes for recycling complex multi-material products at high purity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for affordable methods for detecting and treating the major causes of childhood undernutrition are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for low-bandwidth digital tools that deliver high-quality education in connectivity-poor areas. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for biotechnologies enabling the rapid development of vaccines against unknown future pathogens are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for biotechnologies enabling the sustainable intensification of aquaculture and fisheries. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Achieving farm-scale mapping of mycorrhizal networks and soil carbon at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.