World Solve

Thousands of people die every year waiting for organs that never become available. Lab-grown organs or better donation systems could close this life-threatening gap.

Organ transplants still require lifelong drugs to stop the body from attacking the new organ, and many patients never get a match at all. Lab-grown organs from a patient's own cells could eliminate both problems.

The flu virus mutates constantly, forcing a new vaccine guess every year that sometimes misses the mark. A universal flu vaccine could end this annual guessing game and prevent thousands of deaths.

Modern software is built from thousands of smaller components, any of which could be secretly tampered with. Without full traceability, a single compromised piece can quietly infect software used by millions.

Training today's largest AI models can consume as much electricity as thousands of homes use in a year. Without more efficient methods, AI's environmental cost will keep climbing alongside its capabilities.

Thousands of pieces of space junk are already circling the planet, threatening satellites and future missions. Left unresolved, orbit could become too cluttered and risky to safely launch into.

Even our fastest probes would take tens of thousands of years to reach the nearest star system. Without a breakthrough in propulsion, interstellar travel remains purely theoretical.

Seismologists can identify risky zones but not the exact moment a quake will strike. A few minutes of reliable warning could save thousands of lives in earthquake-prone cities.

The absence of robust, context-adapted solutions for education approaches that build the capacity for systems thinking and long-term decision making creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for autonomous systems for monitoring and maintaining critical undersea infrastructure. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

The absence of robust, context-adapted solutions for solutions for providing safe dignified and sustainable livelihoods for climate-vulnerable populations creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Achieving institutional arrangements that improve the integration of climate considerations into all policy domains at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Achieving mechanisms ensuring that benefits of advanced AI are widely shared rather than concentrated at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

United States has too few licensed physicians per capita to staff rural clinics, and existing task-shifting frameworks for nurses and community health workers lack legal clarity, standardized training, and outcome tracking.

A persistent gap exists in realizing practical, scalable solutions for protocols for the ethical conduct of research involving vulnerable populations in climate-affected regions. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Current approaches to technologies enabling the continuous monitoring of ocean health indicators at global scale either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Despite recognition of its importance, reliable methods for architectural innovations that make high-density living compatible with climate resilience and well-being are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Coastal communities in United States face progressive land loss from sea-level rise, but planned relocation efforts lack frameworks for preserving livelihoods, land rights, and cultural continuity during resettlement.

Communities in Ukraine recovering from disasters have almost no access to trained mental health counselors, and existing psychosocial first-aid programs are not designed to scale past a handful of trained volunteers.

The absence of robust, context-adapted solutions for scalable interventions improving executive function after chronic stress creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.