World Solve

Despite recognition of its importance, reliable methods for biotechnologies enabling the rapid development of vaccines against unknown future pathogens are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for governance models for managing the dual-use risks of advanced gene editing and synthetic biology are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for methods for quantifying and reducing the climate impact of the global food system are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for governance models for shared management of transboundary aquifers and rivers creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to nature-based solutions for landslide and erosion control on steep agricultural lands either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

The absence of robust, context-adapted solutions for methods for restoring coastal wetlands that maximize both carbon and biodiversity co-benefits creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for materials for efficient atmospheric water generation integrated with existing roofs are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for systems ensuring the safety and reliability of autonomous systems in healthcare delivery creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for seasonal underground thermal storage for dense urban district systems. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for governance frameworks for the responsible use of predictive policing and risk assessment tools are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for complete proteins from agricultural lignocellulosic residues creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for biotechnologies enabling the conversion of organic waste into high-value proteins and materials. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

The absence of robust, context-adapted solutions for methods for assessing the resilience of food systems to simultaneous climate and geopolitical shocks creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

The absence of robust, context-adapted solutions for methods for quantifying the health co-benefits of different climate mitigation strategies creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Despite recognition of its importance, reliable methods for designs for energy storage that use only materials available in the Global South at scale are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for governance models preventing catastrophic accidents in high-risk dual-use research facilities. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for quantum-resistant cryptography practical for constrained critical IoT are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for biotechnologies for engineering organisms that contribute to the circular economy and waste reduction are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for materials and designs for buildings that sequester carbon over their full life cycle are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving real-time systems for detecting and responding to the illegal wildlife trade at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.