World Solve

mRNA and vector-based technologies can shorten response times, but manufacturing capacity and regulatory agility must be built in advance. Global manufacturing networks and adaptive trial designs will matter.

Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.

Demand will outpace supply of clinicians unless task-shifting, automation, and new professions emerge. Workforce-planning analytics and training platforms can support transitions.

Over the next 10–20 years, biosensors will track vital signs, metabolites, and behaviours, but analytics and integration into care will lag. Edge-computing and clinically validated algorithms will be needed.

Advances in synthetic biology may blur the line between accidental and deliberate outbreaks. Genomic anomaly detection and secure reporting pipelines could help.

Poor-quality medicines accelerate resistance and treatment failure. Track-and-trace systems and quality-testing infrastructure are needed.

Access to anti-ageing interventions could be skewed toward wealthy groups without deliberate policy. Equity-oriented regulation and public programmes will be required.

Tailored biologics may require complex supply chains. Logistics-optimisation tools and modular manufacturing will be needed.

Uncertainties in ice dynamics, bedrock conditions, and ocean–ice interactions make it hard to forecast tipping points and metres of future sea-level rise. Better grounding-zone measurements and data-assimilation tools could sharpen projections.

Demand for krill-based products and fish drives fleets into sensitive ecosystems that underpin Antarctic food webs. Improved stock assessment and real-time monitoring platforms can inform precautionary management.

Supply chains for fuel, food, and equipment depend on limited routes and budgets, constraining long-term research. Optimisation tools and shared logistics platforms could improve resilience.

Antarctic systems underpin climate regulation and biodiversity, but their economic and non-market value is rarely quantified. Valuation tools and decision-support models could elevate their importance in policy.

Datasets from many nations and disciplines remain siloed, hampering synthesis and reuse. Interoperable data platforms and FAIR-data policies can improve integration.

Debates over future extraction lack robust cost–benefit analyses including climate and ecosystem services. Integrated economic–ecological modelling tools could inform policy.

South American economies grow around 2% per year on average, below global trends, making poverty reduction and fiscal sustainability difficult. Scenario-modelling tools and inclusive industrial-policy platforms can help governments design more resilient growth strategies.

Income, wealth, and access to quality services are highly skewed, limiting social mobility and cohesion across the region. Data-driven social policy design and targeted redistribution mechanisms could help escape the inequality trap.

A large share of workers lack formal contracts, social protection, and stable incomes, undermining productivity and tax bases. Digital formalisation pathways and portable social-benefit platforms can improve inclusion.

Organised crime, drug trafficking, and gangs erode daily life quality and impose large economic costs on South American societies. Integrated crime-data platforms and evidence-based policing tools could support safer communities.

Economic shocks and informality push more city dwellers into precarious living, adding pressure on housing and services. Slum-upgrading and urban social-safety-net platforms could mitigate these trends.

Rural and low-income households often lack connectivity and skills, while firms underinvest in technology. Regional digital-skills and SME-digitalisation platforms can unlock productivity.