World Solve

Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.

Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.

Ultra-processed foods, changing agriculture, and altered gut microbiota may fuel future epidemics of obesity and metabolic disease. Microbiome-targeted therapies and nutrition-policy analytics will be important.

Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.

Cell and gene therapies may deliver durable remissions but have complex safety profiles. Post-marketing registries and patient-reported outcome platforms can close knowledge gaps.

Demand will outpace supply of clinicians unless task-shifting, automation, and new professions emerge. Workforce-planning analytics and training platforms can support transitions.

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

Displaced populations will need continuity of care for chronic diseases and mental health. Portable health records and mobile-clinic platforms can help.

Pervasive digital platforms may exacerbate sleep, focus, and mood problems. New prevention strategies, digital hygiene tools, and regulatory frameworks will be needed.

Lyme disease, dengue, and other infections may reach new regions. Integrated vector-surveillance and control platforms will be crucial.

Bioprinting and stem-cell therapies may not scale fast enough to meet demand. Organ-allocation optimisation and cross-border sharing platforms remain important.

Rising temperatures and changing winds are destabilising ice shelves and altering Southern Ocean circulation, with global implications for sea-level rise and extreme weather. High-resolution coupled climate–ice models and sustained observation networks are needed to predict these changes.

Penguin, krill, and seabird populations are already shifting or declining as habitats change and food webs reorganise. Long-term ecological monitoring and ecosystem-modelling platforms are needed to guide conservation.

Demand for krill-based products and fish drives fleets into sensitive ecosystems that underpin Antarctic food webs. Improved stock assessment and real-time monitoring platforms can inform precautionary management.

Science, tourism, and fishing activities leave infrastructure, pollution, and disturbance, but their combined effects are under-studied. Spatial-impact mapping and cumulative-effects assessment platforms are needed.

Supply chains for fuel, food, and equipment depend on limited routes and budgets, constraining long-term research. Optimisation tools and shared logistics platforms could improve resilience.

Scientific uncertainty makes it hard to define actionable thresholds for ice-sheet or ecosystem collapse in legal instruments. Science–policy translation platforms can help integrate risk ranges into governance.

Organisms survive extreme cold, darkness, and nutrient regimes, but molecular mechanisms are only partly known. Genomic and omics platforms can reveal adaptation strategies.

Antarctic sea-ice changes influence deep-water formation and global heat and carbon transport. Coupled observations and models are essential.

Datasets from many nations and disciplines remain siloed, hampering synthesis and reuse. Interoperable data platforms and FAIR-data policies can improve integration.