World Solve

A persistent gap exists in realizing practical, scalable solutions for solutions for providing reliable and affordable internet access in rural and remote regions. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Achieving AI-assisted discovery of novel antibiotics against Gram-negative pathogens at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

A persistent gap exists in realizing practical, scalable solutions for technologies enabling efficient and low-impact extraction of minerals from seawater and brines. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Assess when and how neglected rail lines can be rehabilitated for low-carbon freight, regional development, and resilient transport.

Reduce dependence on a few suppliers for laboratory reagents, test consumables, and enzymes during epidemics and trade disruptions.

Develop affordable manure management, runoff monitoring, and nutrient-recovery systems for farms too large for household methods but too small for industrial treatment.

The absence of robust, context-adapted solutions for therapeutics and care models that improve outcomes for people living with multimorbidity creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

A persistent gap exists in realizing practical, scalable solutions for governance models for ensuring the equitable distribution of benefits from AI and automation. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

A persistent gap exists in realizing practical, scalable solutions for technologies enabling the continuous monitoring of biodiversity and ecosystem function at scale. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for governance frameworks preventing the concentration of power through advanced surveillance technologies are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

A persistent gap exists in realizing practical, scalable solutions for prognostic monitoring of aging dams and bridges under climate extremes. Scientific understanding, engineering readiness and institutional capacity remain insufficient to translate promising concepts into durable impact under real-world constraints of cost, skills and governance.

Despite recognition of its importance, reliable methods for designs for energy storage that use only materials available in the Global South at scale are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving biotechnologies enabling the sustainable production of alternative proteins at scale at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.