Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
persistent
systems
society-governance
health
whether
public
data
open
Global / Unspecified, Global
Persistent symptoms after infections strain health systems and productivity, yet mechanisms are incompletely understood. Large longitudinal cohorts and mechanistic studies are needed to inform care pathways.
health-biology
global-unspecified
long
covid
post-viral
syndromes
may
remain
significant
burden
2030s
variant
data
society-governance
systems
economics-resources
will
health
open
Global / Unspecified, Global
Post-viral fatigue syndromes, including long COVID, leave some patients exhausted for months or years after the initial infection has cleared, and the biological mechanism remains unclear. Understanding this could unlock treatment for a currently poorly understood condition.
health-biology
global-unspecified
fatigue
long
yet
fully
explain
chronic
sometimes
follows
viral
infections
whether
philosophy-ethics
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Conditions like long COVID and chronic Lyme disease affect some patients severely while others recover fully from the same initial infection. Understanding this difference could unlock treatments for currently unexplained chronic illness.
health-biology
global-unspecified
chronic
some
illness
others
haven
solved
infections
turn
long-term
certain
whether
philosophy-ethics
mathematics-logic
resolved
determine
fully
open
Global / Unspecified, Global
A meaningful share of people who contracted COVID-19 continue experiencing fatigue, brain fog, or other symptoms long after recovery, with no reliably effective treatment yet available. This remains a significant and only partially understood health burden.
philosophy-ethics
global-unspecified
effective
long
symptoms
don
have
way
treat
covid
persist
months
whether
determine
health-biology
resolved
agreed
