World Solve

Achieving low-cost diagnostics and treatments for the major neglected tropical diseases at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Current approaches to selective critical-ion extraction from low-grade brines either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.

Despite recognition of its importance, reliable methods for permafrost carbon abrupt-release early warning models are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Despite recognition of its importance, reliable methods for mechanisms for aligning the incentives of technology companies with broader societal goals are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

Achieving systems ensuring the safety and reliability of AI systems used in critical infrastructure control at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

Despite recognition of its importance, reliable methods for solutions for providing reliable digital connectivity in remote and disaster-affected areas are still lacking. Progress is hindered by incomplete mechanistic knowledge, high capital and operational barriers, and the absence of deployment models suited to the contexts of greatest need.

The absence of robust, context-adapted solutions for nature-based solutions for landslide risk reduction on steep slopes in tropical regions creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Achieving inherently safe modular micro-reactors for remote communities at meaningful scale demands simultaneous progress in fundamental research, engineering integration and socio-technical systems that work for low- and middle-income settings. Existing efforts remain fragmented relative to the magnitude of the challenge.

The absence of robust, context-adapted solutions for methods for assessing the resilience of food systems to simultaneous climate and geopolitical shocks creates cascading risks across interconnected human and natural systems. Key missing elements include durable performance, low lifetime cost, and governance arrangements capable of sustaining impact beyond pilot stages.

Current approaches to methods for assessing the long-term social and environmental impacts of large-scale technological change either underperform under variable field conditions or generate externalities that undermine long-term sustainability and equity. Closing the gap requires coordinated advances in science, systems design and enabling institutions.