Automation may reduce routine collaboration and informal learning, especially for remote and platform workers. Future work design must preserve mentorship, belonging, collective problem-solving, and psychological health. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
europe
germany
preventing
social
isolation
highly
automated
workplaces
under
geopolitical
fragmentation
design
economics-resources
climate-environment
society-governance
systems
quantum
Climate change and urban pumping changes may cause groundwater to enter basements, transit systems, utilities, and foundations. Cities need mapping, waterproofing, drainage, and financing strategies that address slow cumulative damage. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
climate-change
groundwater
adapting
underground
infrastructure
rising
under
geopolitical
fragmentation
climate
change
technology-computing
climate-environment
society-governance
systems
Decision-makers lack integrated, high-resolution models of ocean chemistry, biology, currents, and human activity. The open problem is building trustworthy systems that support decisions without creating false confidence from incomplete data. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
europe
norway
real-time
marine
ecosystem
digital
twins
under
geopolitical
fragmentation
data
decision-makers
economics-resources
society-governance
systems
climate-environment
infrastructure
Growing desalination could produce concentrated brine and chemical waste at scales that threaten coastal ecosystems. The challenge is improving recovery and discharge methods while accounting for cumulative regional impacts. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
asia
indonesia
desalination
brine
ocean
governance
under
geopolitical
fragmentation
growing
produce
concentrated
technology-computing
economics-resources
climate-environment
systems
quantum
If people live substantially longer, societies will need new models for work, learning, housing, dependency, and end-of-life care. Existing systems are not designed for decades of post-retirement life or multiple phases of dependency. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
thailand
care
infrastructure
extreme
longevity
under
geopolitical
fragmentation
dependency
people
live
technology-computing
climate-environment
systems
society-governance
quantum
Modern economies rely on precise timing for finance, telecom, energy, and navigation. Future systems need resilient alternatives to single-source satellite timing during cyberattacks, solar storms, and geopolitical crises. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
science-space
asia
india
timing
secure
space-based
terrestrial
disruptions
low-income
communities
modern
economies
rely
technology-computing
economics-resources
climate-environment
society-governance
systems
Lunar infrastructure and resource extraction could create new strategic inequalities. The challenge is developing rules that enable science and commercial activity while protecting shared interests and preventing territorial competition. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
oceania
australia
access
lunar
equitable
scientific
resources
under
geopolitical
fragmentation
create
infrastructure
technology-computing
climate-environment
society-governance
systems
quantum
open
United States, North America
Autonomous spacecraft may make split-second avoidance decisions using imperfect data and proprietary software. The unresolved problem is assigning responsibility, proving fault, and compensating affected parties across jurisdictions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
north-america
united-states
autonomous
spacecraft
liability
collisions
under
geopolitical
fragmentation
data
may
make
economics-resources
climate-environment
society-governance
systems
infrastructure
open
South Africa, Africa
AI-designed biological molecules may be created faster than their safety, ecological, and clinical properties can be characterized. The open problem is building evaluation pipelines proportionate to capability and deployment risk. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
africa
south-africa
standards
ai-designed
proteins
under
geopolitical
fragmentation
deployment
biological
molecules
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
Large-scale fermentation may compete with food, land, and water if it depends on agricultural inputs. Future systems need safe, affordable, low-carbon feedstocks that do not shift environmental burdens to poorer regions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
asia
india
feedstocks
biomanufacturing
non-food
under
geopolitical
fragmentation
large-scale
fermentation
may
compete
technology-computing
economics-resources
society-governance
systems
infrastructure
Biological design tools are becoming more accessible while oversight remains fragmented across countries and institutions. The challenge is detecting dangerous activity without suppressing legitimate research or creating an intrusive global surveillance system. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
mathematics-logic
asia
india
monitoring
synthetic
biology
risk
under
geopolitical
fragmentation
design
research
technology-computing
economics-resources
society-governance
climate-environment
systems
infrastructure
Quantum capabilities could transform optimization, chemistry, intelligence, and cryptanalysis while becoming concentrated in a few states. The challenge is preventing destabilizing secrecy and unequal access without blocking peaceful scientific collaboration. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
asia
india
quantum
international
governance
advantage
under
geopolitical
fragmentation
access
capabilities
transform
technology-computing
economics-resources
climate-environment
systems
infrastructure
open
European Union, Europe
Frontier AI may become essential infrastructure controlled by a small number of governments or companies. The unresolved task is developing ownership, access, competition, and public-interest models that prevent private or geopolitical concentration from determining global outcomes. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
society-governance
europe
european-union
concentration
geopolitical
preventing
advanced
decision
power
under
fragmentation
access
frontier
technology-computing
economics-resources
climate-environment
systems
infrastructure
Future infrastructure will increasingly rely on systems capable of making decisions without immediate human supervision. The unresolved problem is creating architectures that can prove what they did, explain uncertainty, fail safely, and remain controllable during abnormal conditions. The design must remain functional when standards, trade routes, data access, and diplomatic cooperation are unreliable. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
asia
india
infrastructure
auditable
autonomy
critical
under
geopolitical
fragmentation
remain
future
will
technology-computing
society-governance
climate-environment
systems
quantum
open
Antarctica / Unspecified, Antarctica
Shifts in global power, resource interest, and security concerns challenge consensus-based environmental governance. Scenario-analysis and compliance-monitoring tools can help strengthen the regime.
society-governance
antarctica
antarctica-unspecified
governance
under
antarctic
treaty
system
faces
new
geopolitical
pressures
shifts
frameworks
models
use
ensuring
systems
open
Antarctica / Unspecified, Antarctica
Shifts in global power, resource interest, and security concerns challenge consensus-based environmental governance. Scenario-analysis and compliance-monitoring tools can help strengthen the regime.
society-governance
antarctica
antarctica-unspecified
governance
under
antarctic
treaty
system
faces
new
geopolitical
pressures
variant
data
frameworks
europe
climate-environment
trust
open
Antarctica / Unspecified, Antarctica
Supply chains for fuel, food, and equipment depend on limited routes and budgets, constraining long-term research. Optimisation tools and shared logistics platforms could improve resilience.
economics-resources
antarctica
antarctica-unspecified
supply-chain
logistical
support
antarctic
science
vulnerable
cost
weather
geopolitical
shocks
supply
global-unspecified
climate-environment
african
systems
open
Antarctica / Unspecified, Antarctica
Dual-use technologies and geopolitical competition create ambiguities under the Treaty’s peaceful-use principles. Transparency and monitoring tools can support confidence-building.
society-governance
antarctica
antarctica-unspecified
security
concerns
military
antarctic
infrastructure
rising
dual-use
technologies
geopolitical
competition
monitoring
enabling
continuous
climate-environment
under
open
Antarctica / Unspecified, Antarctica
Dual-use technologies and geopolitical competition create ambiguities under the Treaty’s peaceful-use principles. Transparency and monitoring tools can support confidence-building.
society-governance
antarctica
antarctica-unspecified
monitoring
security
concerns
military
antarctic
infrastructure
rising
variant
focuses
data
climate-environment
technologies
enabling
continuous
systems
open
South & Central Asia, Asia
Melting glaciers and shifting rainfall patterns threaten the reliability of hydropower that many countries depend on, while upstream-downstream tensions complicate new dam projects. Diversified renewable portfolios could reduce over-reliance on hydropower alone.
climate-environment
asia
south-central-asia
hydropower
projects
mountainous
face
rising
climate
geopolitical
risks
melting
global-unspecified
institutional
arrangements
reduce
corruption
society-governance