Repository of problems worth solving
World Solve is a public institutional repository for identifying real unresolved problems across science, society, health, governance, economics, and local systems. Each entry is intended to be citable, inspectable, and actionable.
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4194Total
4194Open
0Solved
9Humans
open
Global / Unspecified, Global
Counterfeit medications sold through unauthorized online channels can be difficult to distinguish from legitimate products without lab testing, putting patients at serious risk. Scalable, affordable detection at the point of purchase remains an unresolved challenge.
health-biology
global-unspecified
affordable
counterfeit
patients
online
yet
build
reliable
technology
detect
pharmaceuticals
whether
philosophy-ethics
mathematics-logic
haven
technology-computing
determine
Poor supply chain oversight allows fake antibiotics, malaria medications, and life-saving drugs to enter rural retail markets, leading to treatment failures and drug resistance.
economics-resources
asia
myanmar
supply-chain
rural
haven
solved
crisis
counterfeit
substandard
pharmaceuticals
circulating
decentralized
pharmacies
global-unspecified
health-biology
african
philosophy-ethics
Frequent power outages degrade essential biological medications in remote clinics, leading to compromised immunization programs.
mathematics-logic
asia
myanmar
haven
developed
scalable
cold-storage
logistics
insulin
temperature-sensitive
vaccines
off-grid
rural
local-regional
health-biology
african
global-unspecified
remains
open
Global / Unspecified, Global
Many common medications cause dry mouth as a side effect, and current treatments manage symptoms rather than addressing the underlying cause, leaving patients with ongoing discomfort and dental risk. A more effective solution remains undeveloped.
health-biology
global-unspecified
effective
dry
mouth
medications
don
have
way
treat
chronic
caused
whether
philosophy-ethics
determine
resolved
agreed
open
Global / Unspecified, Global
Some medications carry a risk of gradual liver damage that often goes undetected until routine screening or symptoms reveal significant harm has already occurred. More sensitive, earlier detection methods remain an unmet need.
health-biology
global-unspecified
liver
damage
haven
solved
detect
early
caused
long-term
medication
becomes
philosophy-ethics
whether
way
determine
resolved
don
open
Global / Unspecified, Global
Long-term use of some widely available pain medications can gradually damage kidney function, often without obvious symptoms until damage is significant. Better awareness and prevention methods remain incompletely applied.
health-biology
global-unspecified
damage
long-term
kidney
pain
medications
haven
solved
prevent
caused
certain
whether
philosophy-ethics
way
mathematics-logic
resolved
determine
open
Global / Unspecified, Global
Chronic skin conditions often require lifelong management with creams and medications rather than a resolution of the underlying immune or genetic causes. A real cure, rather than continuous symptom control, remains unavailable.
health-biology
global-unspecified
chronic
skin
conditions
management
yet
fully
treat
eczema
ongoing
whether
philosophy-ethics
mathematics-logic
haven
determine
resolved
way
open
Global / Unspecified, Global
Millions of people with chronic pain are stuck choosing between inadequate relief or medications that carry serious addiction risk. A safer, equally effective alternative remains one of medicine's most requested breakthroughs.
health-biology
global-unspecified
chronic
pain
addiction
haven
solved
well
enough
treat
risking
millions
philosophy-ethics
whether
way
determine
resolved
mathematics-logic
open
United States, North America
Develop accessible multidimensional diagnostics and treatments for chronic pain that reduce reliance on addictive medications while avoiding dismissal of patient suffering.
health-biology
north-america
united-states
chronic
pain
understanding
treating
opioid
dependence
develop
accessible
multidimensional
diagnostics
global-unspecified
philosophy-ethics
whether
haven
mathematics-logic