Healthcare equipment often uses sterile, complex, or regulated components that are difficult to reuse. Future systems need to reduce waste while preserving infection control and clinical reliability. Affected communities must have meaningful control over data, revenue, deployment decisions, and the right to refuse harmful applications. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
health-biology
circular
manufacturing
medical
devices
community
ownership
control
deployment
healthcare
equipment
technology-computing
economics-resources
climate-environment
society-governance
systems
quantum
infrastructure
Urban planning models often omit informal homes, businesses, infrastructure, and social networks. The unresolved problem is creating useful digital representations without enabling eviction, surveillance, or land speculation. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
local-regional
urban-planning
digital
informal
twins
accurately
represent
neighborhoods
low-income
communities
urban
planning
technology-computing
economics-resources
climate-environment
society-governance
systems
infrastructure
Addressing police often failing to help victims is critical for achieving the 2030 Agenda. Current efforts fall short in scale, speed and equity, leaving the most vulnerable behind. Any viable solution must function in low-resource settings with limited specialists, transport, laboratory capacity and broadband. Proposals should specify quantifiable biological, social or environmental outcomes, openly discuss potential risks, and present a realistic pathway for long-term maintenance and local ownership beyond short research pilots.
police
often
failing
help
victims
mathematics-logic
Works that visibly deteriorate according to how often they are ignored accelerate cultural loss. The problem is supporting art maintenance without turning public attention into a survival requirement for cultural objects.
public
art
preserving
real
time
other
Warnings often fail because people lack transport, trust, shelter, money, or authority to act. The unresolved problem is linking forecasts to pre-agreed decisions, resources, and responsibilities at local level. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
economics-resources
early
warning
systems
trigger
action
rather
only
alerts
low-income
communities
technology-computing
climate-environment
society-governance
infrastructure
quantum
social-civic-problems
science-space
Building codes often use historical temperature, rainfall, and wind data. Future standards must remain useful across uncertain climate trajectories without making housing unaffordable. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
climate-environment
africa
kenya
standards
future
adaptation
buildings
designed
climates
low-income
communities
must
building
technology-computing
economics-resources
society-governance
systems
quantum
Claims about quantum advantage often depend on narrow benchmarks or idealized assumptions. The challenge is creating reproducible measurements that identify when quantum systems deliver meaningful benefits over classical alternatives. The solution must work with limited capital, intermittent services, and local maintenance capacity. The research opportunity is to define measurable success criteria, test the approach in realistic settings, identify failure modes, and create a pathway from prototype to accountable deployment.
technology-computing
quantum
benchmarking
algorithms
against
societal
needs
low-income
communities
identify
claims
economics-resources
climate-environment
society-governance
systems
infrastructure
science-space
safe
open
Brazil, South America
Disasters, conflicts, and public-health crises force governments to buy quickly, often with reduced oversight. The open problem is building emergency procurement systems that are fast enough for crises but transparent enough to prevent leakage, favoritism, and fraud. The challenge is especially acute across fragmented municipalities, where legacy systems, coordination failures, and weak oversight can magnify harm.
society-governance
south-america
brazil
emergency
procurement
fragmented
municipalities
preventing
corruption
crises
oversight
systems
enough
across
technology-computing
public
climate-environment
climate
open
Colombia, South America
Frontline workers often face incomplete records, unreliable connectivity, and high consequences for missed deterioration. Decision-support models must be calibrated locally, auditable, and paired with referral logistics rather than treated as standalone AI. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with verify uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
health-biology
south-america
colombia
referral
might
rural
clinics
decide
patients
need
diagnostic
equipment
scarce
local
actors
mathematics-logic
social-civic-problems
united
Teachers cannot manually inspect every error pattern, while generic adaptive apps often optimize clicks rather than mastery. Compact knowledge models and teacher-controlled workflows could make personalization affordable and pedagogically accountable. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with coordinate uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
social-civic-problems
asia
bangladesh
might
students
crowded
classrooms
receive
practice
matched
misconceptions
teachers
cannot
local
actors
mathematics-logic
united
referral
Curb demand changes by hour and street, but regulations are often static and enforcement is inconsistent. Auctions, reservation systems, and fairness constraints could improve throughput while protecting accessibility and local commerce. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with preserve uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
science-space
africa
egypt
turn
curb
might
cities
unused
space
dynamic
system
deliveries
buses
local
actors
mathematics-logic
social-civic-problems
united
open
Brazil, South America
Competence is often real but invisible to employers because certificates measure course completion rather than performance. Practical assessments, portable evidence, and trusted local validators could improve matching without forcing workers into expensive retraining. The opportunity is intentionally human-scale: a cooperative, clinic, workshop, school, or municipal team could pilot it within one locality and measure outcomes before expanding. Mathematical modeling can help with allocate uncertainty, incentives, or resource constraints; entrepreneurship can turn a reliable workflow into a viable service.
mathematics-logic
south-america
brazil
workers
might
prove
skills
gained
informal
apprenticeships
measure
competence
often
local
actors
social-civic-problems
united
society-governance
open
Global / Unspecified, Global
Bad actors can spread coordinated campaigns across several platforms at once, and current detection systems often work in isolation per platform rather than recognizing the broader cross-platform pattern. Building this kind of coordinated detection remains an unresolved industry challenge.
society-governance
global-unspecified
coordinated
systems
platforms
build
fully
reliable
detect
inauthentic
behavior
multiple
technology-computing
philosophy-ethics
whether
mathematics-logic
haven
resolved
open
Global / Unspecified, Global
Automated scraping tools can collect publicly visible personal data from social media profiles far faster and more comprehensively than manual methods ever could, often for uses the original poster never intended. Meaningful technical or legal limits on this practice remain inconsistent.
philosophy-ethics
global-unspecified
scraping
tools
personal
data
social
media
don
have
scalable
way
whether
resolved
determine
agreed
open
Global / Unspecified, Global
Networks of compromised devices, often unknowing to their owners, can be rented out cheaply on illicit markets for attacks like large-scale website disruptions. Dismantling these persistent botnet infrastructures remains an ongoing cybersecurity challenge.
technology-computing
global-unspecified
cybersecurity
large-scale
rented
out
cheaply
don
have
reliable
way
prevent
botnets
philosophy-ethics
whether
determine
resolved
agreed
open
Global / Unspecified, Global
Once login credentials are leaked in a breach, they often remain accessible and exploitable for attackers on illicit marketplaces for years afterward, long after the original breach was reported. Meaningfully reducing this lingering exposure remains unresolved.
local-regional
global-unspecified
exploitable
years
haven
solved
prevent
large-scale
credential
leaks
remaining
searchable
whether
philosophy-ethics
way
mathematics-logic
resolved
technology-computing
open
Global / Unspecified, Global
Many connected devices become permanently vulnerable once their manufacturer stops issuing security updates, yet the devices often remain in active use for years afterward. A sustainable way to keep abandoned devices secure remains unresolved.
local-regional
global-unspecified
devices
updates
once
haven
solved
make
firmware
older
iot
continue
whether
philosophy-ethics
mathematics-logic
technology-computing
way
resolved
open
Global / Unspecified, Global
Data brokers can aggregate information from many different sources to build surprisingly detailed profiles on individuals, often without those individuals ever being aware or having consented. Meaningful regulation and technical limits on this practice remain inconsistent globally.
society-governance
global-unspecified
data
detailed
profiles
haven
found
way
prevent
large-scale
broker
networks
whether
philosophy-ethics
resolved
technology-computing
mathematics-logic
open
Global / Unspecified, Global
Accessibility efforts often focus more on physical and sensory disabilities than on cognitive accessibility, leaving many users with learning or cognitive differences underserved by mainstream digital design. Closing this specific accessibility gap remains an underaddressed challenge.
technology-computing
global-unspecified
cognitive
users
disabilities
physical
sensory
accessibility
don
have
widely
adopted
whether
philosophy-ethics
way
determine
resolved
agreed
open
Global / Unspecified, Global
Developers often only discover accessibility problems after a product has already launched, since automated tools can't yet catch every meaningful barrier during the build process itself. Building this detection earlier into development workflows remains incomplete.
technology-computing
global-unspecified
yet
build
accessibility
during
development
software
systems
automatically
detect
flag
whether
philosophy-ethics
mathematics-logic
haven
resolved